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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 5, 1060-1065

https://doi.org/10.37358/RC.18.5.6261

Mirela Enache, Ana Maria Toader

Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates

Abstract:

The focus of the present work is to investigate the interaction of anticancer drug mitoxantrone with sodium cholate (NaC) bile salt in phosphate buffer (pH 7.4) and carbonate buffer (pH 10) by UV-Visible absorption spectroscopy. The results indicate that mitoxantrone may bind to NaC monomers and micelles through electrostatic and hydrophobic interactions and the interaction with NaC induces the dissociation of dimers and higher aggregates of mitoxantrone. The stoichiometric ratio, binding constant, micelle/water partition coefficient and the corresponding thermodynamic parameters for binding and partitioning processes were estimated from the monomer absorbance changes occurred as a result of the interaction between mitoxantrone and NaC micelles. The binding process of mitoxantrone to NaC micelles is spontaneous and entropy controlled over the range of studied temperatures, at both pH values. The partition process of mitoxantrone between micellar and bulk aqueous phases is spontaneous and entropy controlled at pH 7.4 but enthalpy controlled at pH 10.
Keywords:
mitoxantrone; bile salts; micelles; binding constant; partition coefficient

Issue: 2018, Volume 69, Issue 5
Pages: 1060-1065
Publication date: 2018/6/15
https://doi.org/10.37358/RC.18.5.6261
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ENACHE, M., TOADER, A.M., Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates, Rev. Chim., 69(5), 2018, 1060-1065.

Vancouver
Enache M, Toader AM. Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates. Rev. Chim.[internet]. 2018 May;69(5):1060-1065. Available from: https://doi.org/10.37358/RC.18.5.6261


APA 6th edition
Enache, M., Toader, A.M. (2018). Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates. Revista de Chimie, 69(5), 1060-1065. https://doi.org/10.37358/RC.18.5.6261


Harvard
Enache, M., Toader, A.M. (2018). 'Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates', Revista de Chimie, 69(5), pp. 1060-1065. https://doi.org/10.37358/RC.18.5.6261


IEEE
M. Enache, A.M. Toader, "Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates". Revista de Chimie, vol. 69, no. 5, pp. 1060-1065, 2018. [online]. https://doi.org/10.37358/RC.18.5.6261


Text
Mirela Enache, Ana Maria Toader,
Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1060-1065,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6261.
(https://revistadechimie.ro/Articles.asp?ID=6261)
Keywords: mitoxantrone; bile salts; micelles; binding constant; partition coefficient


RIS
TY - JOUR
T1 - Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates
A1 - Enache, Mirela
A2 - Toader, Ana Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1060
EP - 1065
UR - https://doi.org/10.37358/RC.18.5.6261
KW - mitoxantrone
KW - bile salts
KW - micelles
KW - binding constant
KW - partition coefficient
ER -


BibTex
@article{RevCh2018P1060,
author = {Enache Mirela and Toader Ana Maria},
title = {Spectroscopic Study of the Interaction of Anticancer Drug Mitoxantrone with Sodium Cholate Aggregates},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1060-1065},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6261},
url = {https://revistadechimie.ro/Articles.asp?ID=6261}
}
 
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