Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing

Totu, Eugenia Eftimie; Cristache, Corina Marilena; Isildak, Ibrahim; Yildirim, Ridvan; Burlibasa, Mihai; Nigde, Mustafa; Burlibasa, Liliana

Eugenia Eftimie Totu, Corina Marilena Cristache, Ibrahim Isildak, Ridvan Yildirim, Mihai Burlibasa, Mustafa Nigde, Liliana Burlibasa

Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing

Abstract:

The aim of the present study was to characterize and preliminary assess the cytotoxicity and genotoxicity of different PMMA-TiO2 nanocomposites suitable to be used for two-parts stereolithographic complete denture manufacturing. In order to improve mechanical and antibacterial characteristics of the materials for 3D printing dentures, two matrix materials consisting in commercially available solutions of poly(methyl methacrylate) (PMMA), referred as dent-PMMA respectively base-PMMA, have been doped with different amount of TiO2 nanoparticles: 0.4, 0.6, 1.0, and 4.0% by weight. The obtained nanocomposites were structural characterized and assessed for antibacterial activity, cytotoxicity and genotoxicity. The newly obtained nanocomposites presented a good inhibitory action against the considered bacterial species-Staphylococcus aureus, good biocompatibility under 4.0% by weight. The results of the preliminary studies on cytotoxicity and genotoxicity assessment recommends the use of 0.4% TiO2 dent-PMMA and base-PMMA for CAD/CAM additive manufacturing of two-parts complete dentures/overdentures.

Keywords:
TiO2 - PMMA nanocomposites; 3D printing; cytotoxicity; genotoxicity; antibacterial activity; structural characterization

Issue: 2018, Volume 69, Issue 5

Pages: 1160-1165

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6281

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TOTU, E.E., CRISTACHE, C.M., ISILDAK, I., YILDIRIM, R., BURLIBASA, M., NIGDE, M., BURLIBASA, L., Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing, Rev. Chim., 69(5), 2018, 1160-1165.

Vancouver
Totu EE, Cristache CM, Isildak I, Yildirim R, Burlibasa M, Nigde M, Burlibasa L. Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing. Rev. Chim.[internet]. 2018 May;69(5):1160-1165. Available from: https://doi.org/10.37358/RC.18.5.6281

APA 6th edition
Totu, E.E., Cristache, C.M., Isildak, I., Yildirim, R., Burlibasa, M., Nigde, M. & Burlibasa, L. (2018). Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing. Revista de Chimie, 69(5), 1160-1165. https://doi.org/10.37358/RC.18.5.6281

Harvard
Totu, E.E., Cristache, C.M., Isildak, I., Yildirim, R., Burlibasa, M., Nigde, M., Burlibasa, L. (2018). 'Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing', Revista de Chimie, 69(5), pp. 1160-1165. https://doi.org/10.37358/RC.18.5.6281

IEEE
E.E. Totu, C.M. Cristache, I. Isildak, R. Yildirim, M. Burlibasa, M. Nigde, L. Burlibasa, "Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing". Revista de Chimie, vol. 69, no. 5, pp. 1160-1165, 2018. [online]. https://doi.org/10.37358/RC.18.5.6281

Text
Eugenia Eftimie Totu, Corina Marilena Cristache, Ibrahim Isildak, Ridvan Yildirim, Mihai Burlibasa, Mustafa Nigde, Liliana Burlibasa,
Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1160-1165,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6281.
(https://revistadechimie.ro/Articles.asp?ID=6281)
Keywords: TiO2 - PMMA nanocomposites; 3D printing; cytotoxicity; genotoxicity; antibacterial activity; structural characterization

RIS
TY - JOUR
T1 - Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing
A1 - Totu, Eugenia Eftimie
A2 - Cristache, Corina Marilena
A3 - Isildak, Ibrahim
A4 - Yildirim, Ridvan
A5 - Burlibasa, Mihai
A6 - Nigde, Mustafa
A7 - Burlibasa, Liliana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1160
EP - 1165
UR - https://doi.org/10.37358/RC.18.5.6281
KW - TiO2 - PMMA nanocomposites
KW - 3D printing
KW - cytotoxicity
KW - genotoxicity
KW - antibacterial activity
KW - structural characterization
ER -

BibTex
@article{RevCh2018P1160,
author = {Totu Eugenia Eftimie and Cristache Corina Marilena and Isildak Ibrahim and Yildirim Ridvan and Burlibasa Mihai and Nigde Mustafa and Burlibasa Liliana},
title = {Preliminary Studies on Citotoxicity and Genotoxicity Assessment of the PMMA-TiO2 Nanocompozites for Stereolithographic Complete Dentures Manufacturing},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1160-1165},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6281},
url = {https://revistadechimie.ro/Articles.asp?ID=6281}
}

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