Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells

Tatarciuc, Diana; Vasincu, Decebal; Stoleriu, Gabriela; Iancu, Roxana Irina; Costuleanu, Marcel

Diana Tatarciuc, Decebal Vasincu, Gabriela Stoleriu, Roxana Irina Iancu, Marcel Costuleanu

Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells

Abstract:

The intracellular renin-angiotensin effectors (peptides, enzymes, receptors) and their effects are intriguing for a lot of systems. That’s why we aimed the effects of intracellularly-administered angiotensins (angiotensin II, angiotensin III, angiotensin IV, angiotensin fragment 1-7), angiotensinogen, CGP-42112A, apelin, and angiotensin receptors blockers (losartan, PD123319), by the means of liposomes, on apoptosis of cultured isolated rat aortic vascular smooth muscle cells. We evidenced that CGP-42112A (a potent AT2 angiotensin II receptor agonist), administered intracellularly, induced the apoptosis of the cultured isolated vascular smooth muscle cells in a much higher proportion than other agonists and antagonists of angiotensin system: CGP-42112A ] angiotensin II] angiotensin III@ angiotensinogen. Moreover, losartan (an AT1 angiotensin II receptor antagonist), administered intracellularly, induced an important degree of apoptosis of cultured isolated vascular smooth muscle cells. Losartan, administered as concomitant treatment for other angiotensin peptides and CGP-42112A, did not significantly modified the apoptotic effects of these peptides. On the other hand, PD123319 (an AT2 angiotensin II receptor antagonist) was able to significantly reduce the losartan effects when administered as co-treatment for 24 h. The same effects were obtained when LY294002, a PI3K/Akt signaling inhibitor, was administered as a co-treatment. We can conclude an involvement of an AT2 angiotensin II receptor and PI3K/Akt signaling in these apoptotic effects induced by some angiotensin peptides and losartan on cultured isolated rat aortic vascular smooth muscle cells.

Keywords:
vascular smooth muscle cells; rat aorta; intracellular angiotensin; losartan; apoptosis

Issue: 2018, Volume 69, Issue 5

Pages: 1187-1190

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6285

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TATARCIUC, D., VASINCU, D., STOLERIU, G., IANCU, R.I., COSTULEANU, M., Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells, Rev. Chim., 69(5), 2018, 1187-1190.

Vancouver
Tatarciuc D, Vasincu D, Stoleriu G, Iancu RI, Costuleanu M. Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells. Rev. Chim.[internet]. 2018 May;69(5):1187-1190. Available from: https://doi.org/10.37358/RC.18.5.6285

APA 6th edition
Tatarciuc, D., Vasincu, D., Stoleriu, G., Iancu, R.I. & Costuleanu, M. (2018). Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells. Revista de Chimie, 69(5), 1187-1190. https://doi.org/10.37358/RC.18.5.6285

Harvard
Tatarciuc, D., Vasincu, D., Stoleriu, G., Iancu, R.I., Costuleanu, M. (2018). 'Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells', Revista de Chimie, 69(5), pp. 1187-1190. https://doi.org/10.37358/RC.18.5.6285

IEEE
D. Tatarciuc, D. Vasincu, G. Stoleriu, R.I. Iancu, M. Costuleanu, "Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells". Revista de Chimie, vol. 69, no. 5, pp. 1187-1190, 2018. [online]. https://doi.org/10.37358/RC.18.5.6285

Text
Diana Tatarciuc, Decebal Vasincu, Gabriela Stoleriu, Roxana Irina Iancu, Marcel Costuleanu,
Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1187-1190,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6285.
(https://revistadechimie.ro/Articles.asp?ID=6285)
Keywords: vascular smooth muscle cells; rat aorta; intracellular angiotensin; losartan; apoptosis

RIS
TY - JOUR
T1 - Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells
A1 - Tatarciuc, Diana
A2 - Vasincu, Decebal
A3 - Stoleriu, Gabriela
A4 - Iancu, Roxana Irina
A5 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1187
EP - 1190
UR - https://doi.org/10.37358/RC.18.5.6285
KW - vascular smooth muscle cells
KW - rat aorta
KW - intracellular angiotensin
KW - losartan
KW - apoptosis
ER -

BibTex
@article{RevCh2018P1187,
author = {Tatarciuc Diana and Vasincu Decebal and Stoleriu Gabriela and Iancu Roxana Irina and Costuleanu Marcel},
title = {Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1187-1190},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6285},
url = {https://revistadechimie.ro/Articles.asp?ID=6285}
}

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