Study on Forms of Intoxication with Cocaine and Evolutionary Aspects

David, Sofia; Knieling, Anton; Damian, Simona Irina; Diac, Madalina; Sandu, Ion; Iov, Tatiana

Sofia David, Anton Knieling, Simona Irina Damian, Madalina Diac, Ion Sandu, Tatiana Iov

Study on Forms of Intoxication with Cocaine and Evolutionary Aspects

Abstract:

Cocaine is an alkaloid obtained from the leaves of the coca plant, Erythroxylum coca. Cocaine sulfate, a brown paste, is obtained from coca leaves and from this, cocaine hydrochloride, a white substance, soluble in water and with a bitter taste that may be in the form of white crystals or powder. From cocaine hydrochloride crack is obtained by heating, a more purified form and with greater power of intoxication and addiction. Once in the organism, cocaine behaves like an indirect sympathomimetic amine and produces a blockade of the presynaptic reuptake of dopamine, adrenaline, noradrenaline and serotonin, thus increasing their levels. At the cardiovascular level cocaine is responsible for malignant arrhythmias, sometimes responsible for sudden death. Other symptoms that can occur are aortic dissection, arterial hypertension and coronary vasoconstriction able to trigger an acute myocardial infarction. The authors present a case of sudden cardiac death due to cocaine intoxication in a young male without any cardiac risk factors. The autopsy, together with the results of the complementary tests, indicate that the most probable death mechanism has been a cardiogenic shock secondary to extensive myocardial necrosis due to cocaine intoxication.

Keywords:
cocaine; alkaloid; intoxication; cardiogenic shock; death; autopsy

Issue: 2018, Volume 69, Issue 5

Pages: 1216-1219

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6292

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DAVID, S., KNIELING, A., DAMIAN, S.I., DIAC, M., SANDU, I., IOV, T., Study on Forms of Intoxication with Cocaine and Evolutionary Aspects, Rev. Chim., 69(5), 2018, 1216-1219.

Vancouver
David S, Knieling A, Damian SI, Diac M, Sandu I, Iov T. Study on Forms of Intoxication with Cocaine and Evolutionary Aspects. Rev. Chim.[internet]. 2018 May;69(5):1216-1219. Available from: https://doi.org/10.37358/RC.18.5.6292

APA 6th edition
David, S., Knieling, A., Damian, S.I., Diac, M., Sandu, I. & Iov, T. (2018). Study on Forms of Intoxication with Cocaine and Evolutionary Aspects. Revista de Chimie, 69(5), 1216-1219. https://doi.org/10.37358/RC.18.5.6292

Harvard
David, S., Knieling, A., Damian, S.I., Diac, M., Sandu, I., Iov, T. (2018). 'Study on Forms of Intoxication with Cocaine and Evolutionary Aspects', Revista de Chimie, 69(5), pp. 1216-1219. https://doi.org/10.37358/RC.18.5.6292

IEEE
S. David, A. Knieling, S.I. Damian, M. Diac, I. Sandu, T. Iov, "Study on Forms of Intoxication with Cocaine and Evolutionary Aspects". Revista de Chimie, vol. 69, no. 5, pp. 1216-1219, 2018. [online]. https://doi.org/10.37358/RC.18.5.6292

Text
Sofia David, Anton Knieling, Simona Irina Damian, Madalina Diac, Ion Sandu, Tatiana Iov,
Study on Forms of Intoxication with Cocaine and Evolutionary Aspects,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1216-1219,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6292.
(https://revistadechimie.ro/Articles.asp?ID=6292)
Keywords: cocaine; alkaloid; intoxication; cardiogenic shock; death; autopsy

RIS
TY - JOUR
T1 - Study on Forms of Intoxication with Cocaine and Evolutionary Aspects
A1 - David, Sofia
A2 - Knieling, Anton
A3 - Damian, Simona Irina
A4 - Diac, Madalina
A5 - Sandu, Ion
A6 - Iov, Tatiana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1216
EP - 1219
UR - https://doi.org/10.37358/RC.18.5.6292
KW - cocaine
KW - alkaloid
KW - intoxication
KW - cardiogenic shock
KW - death
KW - autopsy
ER -

BibTex
@article{RevCh2018P1216,
author = {David Sofia and Knieling Anton and Damian Simona Irina and Diac Madalina and Sandu Ion and Iov Tatiana},
title = {Study on Forms of Intoxication with Cocaine and Evolutionary Aspects},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1216-1219},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6292},
url = {https://revistadechimie.ro/Articles.asp?ID=6292}
}

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