The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation

Osakwe, Henry; Nicolescu, Cristian; Nicolescu, Laura; Hoinoiu, Bogdan; Mederle, Ovidiu; Mussuto, Elisa; Popoiu, Calin; Boia, Eugen

Henry Osakwe, Cristian Nicolescu, Laura Nicolescu, Bogdan Hoinoiu, Ovidiu Mederle, Elisa Mussuto, Calin Popoiu, Eugen Boia

The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation

Abstract:

The intestinal mucosa is a major barrier in preventing bacteria invading the body but under certain circumstances mucosal gut barrier can be breached leading to the migration of bacteria to distant organs (mesenteric lymph nodes, spleen and liver). This process is termed bacterial translocation. The abnormal changes in gut ecosystem due to bowel resection led to bacterial overgrowth demonstrated postoperatively in male wistar rats duodenal and stool culture. We proved that after an extended bowel resection there is a direct relation between the number of the intestinal bacteria, the abnormal mucosal structural and functional changes and bacterial translocation to distant organs. A total of 22 male wistar rats divided in 4 groups were studied, short bowel syndrome was simulated in 16 by extended bowel resection (60%, 70% and 75%) while 6 rats had no surgery. Bacterial toxins induced local inflammation which altered neuromuscular tissue function, deteriorated further the gut barrier and increased bacterial overgrowth and bacterial translocation demonstrated by rat‘s intestinal biopsy results. The sequence of events leading to translocation remained unclear. The correlation between the percentage of the duodenal aspirate Enterococcus and cecal stool bacteria in rats was R= 0.81, while the correlation between duodenal aspirate Enterococcus and cecal stool bacteria of rats without ileocecal valve resection compared to rats with ileocecal valve resection was R= 0.57 being statistically relevant. Simulated short bowel syndrome by extended intestinal resection caused bacteria overgrowth in residual rat‘s bowel and this subsequently led to bacteria translocation to distant organs.

Keywords:
Bacterial translocation; Bacterial overgrowth; Intestinal resection; Bowel adaptation; Duodenal aspirate

Issue: 2018, Volume 69, Issue 8

Pages: 2121-2128

Publication date: 2018/9/15

https://doi.org/10.37358/RC.18.8.6486

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
OSAKWE, H., NICOLESCU, C., NICOLESCU, L., HOINOIU, B., MEDERLE, O., MUSSUTO, E., POPOIU, C., BOIA, E., The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation, Rev. Chim., 69(8), 2018, 2121-2128.

Vancouver
Osakwe H, Nicolescu C, Nicolescu L, Hoinoiu B, Mederle O, Mussuto E, Popoiu C, Boia E. The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation. Rev. Chim.[internet]. 2018 Aug;69(8):2121-2128. Available from: https://doi.org/10.37358/RC.18.8.6486

APA 6th edition
Osakwe, H., Nicolescu, C., Nicolescu, L., Hoinoiu, B., Mederle, O., Mussuto, E., Popoiu, C. & Boia, E. (2018). The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation. Revista de Chimie, 69(8), 2121-2128. https://doi.org/10.37358/RC.18.8.6486

Harvard
Osakwe, H., Nicolescu, C., Nicolescu, L., Hoinoiu, B., Mederle, O., Mussuto, E., Popoiu, C., Boia, E. (2018). 'The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation', Revista de Chimie, 69(8), pp. 2121-2128. https://doi.org/10.37358/RC.18.8.6486

IEEE
H. Osakwe, C. Nicolescu, L. Nicolescu, B. Hoinoiu, O. Mederle, E. Mussuto, C. Popoiu, E. Boia, "The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation". Revista de Chimie, vol. 69, no. 8, pp. 2121-2128, 2018. [online]. https://doi.org/10.37358/RC.18.8.6486

Text
Henry Osakwe, Cristian Nicolescu, Laura Nicolescu, Bogdan Hoinoiu, Ovidiu Mederle, Elisa Mussuto, Calin Popoiu, Eugen Boia,
The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation,
Revista de Chimie,
Volume 69, Issue 8,
2018,
Pages 2121-2128,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.8.6486.
(https://revistadechimie.ro/Articles.asp?ID=6486)
Keywords: Bacterial translocation; Bacterial overgrowth; Intestinal resection; Bowel adaptation; Duodenal aspirate

RIS
TY - JOUR
T1 - The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation
A1 - Osakwe, Henry
A2 - Nicolescu, Cristian
A3 - Nicolescu, Laura
A4 - Hoinoiu, Bogdan
A5 - Mederle, Ovidiu
A6 - Mussuto, Elisa
A7 - Popoiu, Calin
A8 - Boia, Eugen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 8
SP - 2121
EP - 2128
UR - https://doi.org/10.37358/RC.18.8.6486
KW - Bacterial translocation
KW - Bacterial overgrowth
KW - Intestinal resection
KW - Bowel adaptation
KW - Duodenal aspirate
ER -

BibTex
@article{RevCh2018P2121,
author = {Osakwe Henry and Nicolescu Cristian and Nicolescu Laura and Hoinoiu Bogdan and Mederle Ovidiu and Mussuto Elisa and Popoiu Calin and Boia Eugen},
title = {The Impact of Residual Bowel After Extended Bowel Resection on Bacterial Overgrowth and Bacterial Translocation},
journal = {Revista de Chimie},
volume = {69},
number = {8},
pages = {2121-2128},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.8.6486},
url = {https://revistadechimie.ro/Articles.asp?ID=6486}
}

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