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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 9, 2346-2350

https://doi.org/10.37358/RC.18.9.6531

Stefania Felicia Barbuceanu, Octavian Tudorel Olaru, George Mihai Nitulescu, Constantin Draghici, Laura Ileana Socea, Florica Barbuceanu, Cristian Enache, Gabriel Saramet

Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles

Abstract:

This paper presents a continuation of our studies in the synthesis of some 1,2,4-triazole-3-thiones and 1,3,4-thiadiazol-2-amines containing in their molecules the fluorine atom. For the synthesis of these heterocycles, the hydrazinecarbothioamides, 2-(4-(4-X-phenylsulfonyl)benzoyl)-N-(3-fluorophenyl) hydrazinecarbo-thioamides 2a-c, were obtained by treatment of some 4-(4-X-phenylsulfonyl)-benzoic acid hydrazides 1a-c with 3-fluorophenyl isothiocyanate. The new 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-fluorophenyl)-2H-1,2,4-triazole-3(4H)-thiones 3a-c were obtained by refluxing of hydrazinecarbothioamide 2a-c with a solution natrium hidroxide and the 5-(4-(4-X-phenylsulfonyl)phenyl)-N-(3-fluorophenyl)-1,3,4-thiadiazol-2-amines 4a-c were synthesized by refluxing of hydrazinecarbothioamides 2a-c with phosphorus oxychloride. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectral data and by elemental analysis. The compounds have been tested on Daphnia magna for their toxicity assessment.
Keywords:
1;2;4-triazole-3-thione; 1;3;4-thiadiazol-2-amine; hydrazinecarbothioamides; heterocyclization; anti-virulence activit

Issue: 2018, Volume 69, Issue 9
Pages: 2346-2350
Publication date: 2018/10/15
https://doi.org/10.37358/RC.18.9.6531
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BARBUCEANU, S.F., OLARU, O.T., NITULESCU, G.M., DRAGHICI, C., SOCEA, L.I., BARBUCEANU, F., ENACHE, C., SARAMET, G., Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles, Rev. Chim., 69(9), 2018, 2346-2350.

Vancouver
Barbuceanu SF, Olaru OT, Nitulescu GM, Draghici C, Socea LI, Barbuceanu F, Enache C, Saramet G. Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles. Rev. Chim.[internet]. 2018 Sep;69(9):2346-2350. Available from: https://doi.org/10.37358/RC.18.9.6531


APA 6th edition
Barbuceanu, S.F., Olaru, O.T., Nitulescu, G.M., Draghici, C., Socea, L.I., Barbuceanu, F., Enache, C. & Saramet, G. (2018). Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles. Revista de Chimie, 69(9), 2346-2350. https://doi.org/10.37358/RC.18.9.6531


Harvard
Barbuceanu, S.F., Olaru, O.T., Nitulescu, G.M., Draghici, C., Socea, L.I., Barbuceanu, F., Enache, C., Saramet, G. (2018). 'Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles', Revista de Chimie, 69(9), pp. 2346-2350. https://doi.org/10.37358/RC.18.9.6531


IEEE
S.F. Barbuceanu, O.T. Olaru, G.M. Nitulescu, C. Draghici, L.I. Socea, F. Barbuceanu, C. Enache, G. Saramet, "Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles". Revista de Chimie, vol. 69, no. 9, pp. 2346-2350, 2018. [online]. https://doi.org/10.37358/RC.18.9.6531


Text
Stefania Felicia Barbuceanu, Octavian Tudorel Olaru, George Mihai Nitulescu, Constantin Draghici, Laura Ileana Socea, Florica Barbuceanu, Cristian Enache, Gabriel Saramet,
Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2346-2350,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6531.
(https://revistadechimie.ro/Articles.asp?ID=6531)
Keywords: 1;2;4-triazole-3-thione; 1;3;4-thiadiazol-2-amine; hydrazinecarbothioamides; heterocyclization; anti-virulence activit


RIS
TY - JOUR
T1 - Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles
A1 - Barbuceanu, Stefania Felicia
A2 - Olaru, Octavian Tudorel
A3 - Nitulescu, George Mihai
A4 - Draghici, Constantin
A5 - Socea, Laura Ileana
A6 - Barbuceanu, Florica
A7 - Enache, Cristian
A8 - Saramet, Gabriel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2346
EP - 2350
UR - https://doi.org/10.37358/RC.18.9.6531
KW - 1
KW - 2
KW - 4-triazole-3-thione
KW - 1
KW - 3
KW - 4-thiadiazol-2-amine
KW - hydrazinecarbothioamides
KW - heterocyclization
KW - anti-virulence activit
ER -


BibTex
@article{RevCh2018P2346,
author = {Barbuceanu Stefania Felicia and Olaru Octavian Tudorel and Nitulescu George Mihai and Draghici Constantin and Socea Laura Ileana and Barbuceanu Florica and Enache Cristian and Saramet Gabriel},
title = {Synthesis and Structural Characterization of Some Potential Anti-Virulence 1,2,4-Triazoles and 1,3,4-Thiadiazoles},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2346-2350},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6531},
url = {https://revistadechimie.ro/Articles.asp?ID=6531}
}
 
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