Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures

Lupescu, Doriana; Greabu, Maria; Totan, Alexandra; Nagea, Mihail; Popescu, Gheorghe Ion; Lupescu, Olivera; Dimitriu, Alexandru Lisias; Stoian, Irina; Grintescu, Ioana Marina; Corneci, Dan

Doriana Lupescu, Maria Greabu, Alexandra Totan, Mihail Nagea, Gheorghe Ion Popescu, Olivera Lupescu, Alexandru Lisias Dimitriu, Irina Stoian, Ioana Marina Grintescu, Dan Corneci

Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures

Abstract:

Polytrauma represents one of the most challenging aspects of modern medicine, due to its high mortality and morbidity, affecting especially young, active patients. Therefore, research is nowadays directed towards optimising the treatment for these patients, which is extremely difficult, as polytrauma is characterized by a complicated pathophysiology with intricate pathways, potentially generating local and general complications and requiring a multidisciplinary approach. An essential issue for these patients is a careful monitoring algorithm, able to determine an appropriate therapeutic response in due time, so objective, measurable and reproducible elements able to do this have been sought. Since biochemical markers have these properties, and the most important pathogenic element in polytrauma is the Systemic Inflammatory Response Syndrome (SIRS), the authors of this paper evaluate the predictive value of inflammatory markers in order to improve the monitoring algorithm of these patients. The results of this prospective study demonstrate some statistically significant correlations, such as those between lactate (at admission and 24 hours later) and mortality, as well as between IL-6 and early systemic complications, which are of great value because they can concentrate the efforts of the multidisciplinary team and save the life of the poytrauma patient.

Keywords:
polytrauma; IL-6; inflammatory response; damage control

Issue: 2018, Volume 69, Issue 10

Pages: 2762-2767

Publication date: 2018/11/15

https://doi.org/10.37358/RC.18.10.6621

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUPESCU, D., GREABU, M., TOTAN, A., NAGEA, M., POPESCU, G.I., LUPESCU, O., DIMITRIU, A.L., STOIAN, I., GRINTESCU, I.M., CORNECI, D., Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures, Rev. Chim., 69(10), 2018, 2762-2767.

Vancouver
Lupescu D, Greabu M, Totan A, Nagea M, Popescu GI, Lupescu O, Dimitriu AL, Stoian I, Grintescu IM, Corneci D. Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures. Rev. Chim.[internet]. 2018 Oct;69(10):2762-2767. Available from: https://doi.org/10.37358/RC.18.10.6621

APA 6th edition
Lupescu, D., Greabu, M., Totan, A., Nagea, M., Popescu, G.I., Lupescu, O.,... Corneci, D. (2018). Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures. Revista de Chimie, 69(10), 2762-2767. https://doi.org/10.37358/RC.18.10.6621

Harvard
Lupescu, D., Greabu, M., Totan, A., Nagea, M., Popescu, G.I., Lupescu, O., Dimitriu, A.L., Stoian, I., Grintescu, I.M., Corneci, D. (2018). 'Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures', Revista de Chimie, 69(10), pp. 2762-2767. https://doi.org/10.37358/RC.18.10.6621

IEEE
D. Lupescu, M. Greabu, A. Totan, M. Nagea, G.I. Popescu, O. Lupescu, A.L. Dimitriu, I. Stoian, I.M. Grintescu, D. Corneci, "Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures". Revista de Chimie, vol. 69, no. 10, pp. 2762-2767, 2018. [online]. https://doi.org/10.37358/RC.18.10.6621

Text
Doriana Lupescu, Maria Greabu, Alexandra Totan, Mihail Nagea, Gheorghe Ion Popescu, Olivera Lupescu, Alexandru Lisias Dimitriu, Irina Stoian, Ioana Marina Grintescu, Dan Corneci,
Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2762-2767,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6621.
(https://revistadechimie.ro/Articles.asp?ID=6621)
Keywords: polytrauma; IL-6; inflammatory response; damage control

RIS
TY - JOUR
T1 - Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures
A1 - Lupescu, Doriana
A2 - Greabu, Maria
A3 - Totan, Alexandra
A4 - Nagea, Mihail
A5 - Popescu, Gheorghe Ion
A6 - Lupescu, Olivera
A7 - Dimitriu, Alexandru Lisias
A8 - Stoian, Irina
A9 - Grintescu, Ioana Marina
A10 - Corneci, Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2762
EP - 2767
UR - https://doi.org/10.37358/RC.18.10.6621
KW - polytrauma
KW - IL-6
KW - inflammatory response
KW - damage control
ER -

BibTex
@article{RevCh2018P2762,
author = {Lupescu Doriana and Greabu Maria and Totan Alexandra and Nagea Mihail and Popescu Gheorghe Ion and Lupescu Olivera and Dimitriu Alexandru Lisias and Stoian Irina and Grintescu Ioana Marina and Corneci Dan},
title = {Biochemical Markers with Predictive Value in Polytrauma Patients with Femoral Fractures},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2762-2767},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6621},
url = {https://revistadechimie.ro/Articles.asp?ID=6621}
}

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