Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey

Morariu, Ionela Daniela; Avasilcai, Liliana; Vieriu, Madalina; Panainte, Alina Diana; Bibire, Nela

Ionela Daniela Morariu, Liliana Avasilcai, Madalina Vieriu, Alina Diana Panainte, Nela Bibire

Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey

Abstract:

Although nitrofurans are supposed to be absent in foods, they are still used in veterinary medicine for the treatment of infections in animals not bred for consumption. That meant that there are still samples of honey contaminated with residues of nitrofurans because of bees treated with those pharmaceutical substances. Developing accessible methods to detect them is of high interest to food residue monitoring and regulation programs. We propose an immunochemical method as an alternative to detect four toxic metabolites of nitrofurans (1-aminoimidazolidine-2,4-dione, 3-amino-5-morpholinomethyl-2-oxazolidinone, 3-amino-2-oxazolidone and semicarbazide) in honey. The new method has been optimized and validate for the simultaneous determination of the four metabolites of the nitrofurans honey using biochip technology, and it has been used for the quantitative determination of the residues in 16 Romanian honey samples. The evaluated validation parameters included: linearity, sensitivity (IC50 £2.32 mg/kg), specificity and selectivity, precision (intermediate and reproducibility) and accuracy, decision limit (CCa between 0.37 and 1.05 mg/kg), detection capability (CCb between 0.42 and 1.14 mg/kg), and recovery coefficient (64-192%).

Keywords:
nitrofurans; honey; biochip

Issue: 2018, Volume 69, Issue 10

Pages: 2808-2812

Publication date: 2018/11/15

https://doi.org/10.37358/RC.18.10.6629

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MORARIU, I.D., AVASILCAI, L., VIERIU, M., PANAINTE, A.D., BIBIRE, N., Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey, Rev. Chim., 69(10), 2018, 2808-2812.

Vancouver
Morariu ID, Avasilcai L, Vieriu M, Panainte AD, Bibire N. Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey. Rev. Chim.[internet]. 2018 Oct;69(10):2808-2812. Available from: https://doi.org/10.37358/RC.18.10.6629

APA 6th edition
Morariu, I.D., Avasilcai, L., Vieriu, M., Panainte, A.D. & Bibire, N. (2018). Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey. Revista de Chimie, 69(10), 2808-2812. https://doi.org/10.37358/RC.18.10.6629

Harvard
Morariu, I.D., Avasilcai, L., Vieriu, M., Panainte, A.D., Bibire, N. (2018). 'Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey', Revista de Chimie, 69(10), pp. 2808-2812. https://doi.org/10.37358/RC.18.10.6629

IEEE
I.D. Morariu, L. Avasilcai, M. Vieriu, A.D. Panainte, N. Bibire, "Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey". Revista de Chimie, vol. 69, no. 10, pp. 2808-2812, 2018. [online]. https://doi.org/10.37358/RC.18.10.6629

Text
Ionela Daniela Morariu, Liliana Avasilcai, Madalina Vieriu, Alina Diana Panainte, Nela Bibire,
Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2808-2812,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6629.
(https://revistadechimie.ro/Articles.asp?ID=6629)
Keywords: nitrofurans; honey; biochip

RIS
TY - JOUR
T1 - Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey
A1 - Morariu, Ionela Daniela
A2 - Avasilcai, Liliana
A3 - Vieriu, Madalina
A4 - Panainte, Alina Diana
A5 - Bibire, Nela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2808
EP - 2812
UR - https://doi.org/10.37358/RC.18.10.6629
KW - nitrofurans
KW - honey
KW - biochip
ER -

BibTex
@article{RevCh2018P2808,
author = {Morariu Ionela Daniela and Avasilcai Liliana and Vieriu Madalina and Panainte Alina Diana and Bibire Nela},
title = {Validation and Application of an Analysis Method of Four Metabolites of Nitrofurans in Honey},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2808-2812},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6629},
url = {https://revistadechimie.ro/Articles.asp?ID=6629}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)