Nefopam and its Role in Modulating Acute and Chronic Pain

Tiglis, Mirela; Neagu, Tiberiu Paul; Elfara, Mazen; Diaconu, Camelia Cristina; Bratu, Ovidiu Gabriel; Vacaroiu, Ileana Adela; Grintescu, Ioana Marina

Mirela Tiglis, Tiberiu Paul Neagu, Mazen Elfara, Camelia Cristina Diaconu, Ovidiu Gabriel Bratu, Ileana Adela Vacaroiu, Ioana Marina Grintescu

Nefopam and its Role in Modulating Acute and Chronic Pain

Abstract:

Pain is a very important issue to take into account during hospitalization. Nefopam, a centrally acting analgesic, has a relative safety pharmacological profile with few and well-tolerated side effects, being used to treat acute or chronic pain. It inhibits the central reuptake of serotonin, norepinephrine and dopamine and modulates the sodium and calcium channels having only few contraindications. Nefopam can be part of balanced analgesia along with others non-opioids agents in order to reduce the opioid consumption and their complications, to control postoperative pain and to reduce the risk of neuropathic pain appearance. In order to avoid its adverse reactions, a slow infusion is always recommended. Nefopam has its role in preventing the shivering appearance during neuraxial or general anesthesia, can modulate the emergence agitation after nasal and maxillofacial surgery and can inhibit the sever hiccup during mechanical ventilation. Some cases about fatal overdoses are reported in the literature.

Keywords:
nefopam; acute or chronic pain; balanced analgesia; slow injection

Issue: 2018, Volume 69, Issue 10

Pages: 2877-2880

Publication date: 2018/11/15

https://doi.org/10.37358/RC.18.10.6644

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TIGLIS, M., NEAGU, T.P., ELFARA, M., DIACONU, C.C., BRATU, O.G., VACAROIU, I.A., GRINTESCU, I.M., Nefopam and its Role in Modulating Acute and Chronic Pain, Rev. Chim., 69(10), 2018, 2877-2880.

Vancouver
Tiglis M, Neagu TP, Elfara M, Diaconu CC, Bratu OG, Vacaroiu IA, Grintescu IM. Nefopam and its Role in Modulating Acute and Chronic Pain. Rev. Chim.[internet]. 2018 Oct;69(10):2877-2880. Available from: https://doi.org/10.37358/RC.18.10.6644

APA 6th edition
Tiglis, M., Neagu, T.P., Elfara, M., Diaconu, C.C., Bratu, O.G., Vacaroiu, I.A. & Grintescu, I.M. (2018). Nefopam and its Role in Modulating Acute and Chronic Pain. Revista de Chimie, 69(10), 2877-2880. https://doi.org/10.37358/RC.18.10.6644

Harvard
Tiglis, M., Neagu, T.P., Elfara, M., Diaconu, C.C., Bratu, O.G., Vacaroiu, I.A., Grintescu, I.M. (2018). 'Nefopam and its Role in Modulating Acute and Chronic Pain', Revista de Chimie, 69(10), pp. 2877-2880. https://doi.org/10.37358/RC.18.10.6644

IEEE
M. Tiglis, T.P. Neagu, M. Elfara, C.C. Diaconu, O.G. Bratu, I.A. Vacaroiu, I.M. Grintescu, "Nefopam and its Role in Modulating Acute and Chronic Pain". Revista de Chimie, vol. 69, no. 10, pp. 2877-2880, 2018. [online]. https://doi.org/10.37358/RC.18.10.6644

Text
Mirela Tiglis, Tiberiu Paul Neagu, Mazen Elfara, Camelia Cristina Diaconu, Ovidiu Gabriel Bratu, Ileana Adela Vacaroiu, Ioana Marina Grintescu,
Nefopam and its Role in Modulating Acute and Chronic Pain,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2877-2880,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6644.
(https://revistadechimie.ro/Articles.asp?ID=6644)
Keywords: nefopam; acute or chronic pain; balanced analgesia; slow injection

RIS
TY - JOUR
T1 - Nefopam and its Role in Modulating Acute and Chronic Pain
A1 - Tiglis, Mirela
A2 - Neagu, Tiberiu Paul
A3 - Elfara, Mazen
A4 - Diaconu, Camelia Cristina
A5 - Bratu, Ovidiu Gabriel
A6 - Vacaroiu, Ileana Adela
A7 - Grintescu, Ioana Marina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2877
EP - 2880
UR - https://doi.org/10.37358/RC.18.10.6644
KW - nefopam
KW - acute or chronic pain
KW - balanced analgesia
KW - slow injection
ER -

BibTex
@article{RevCh2018P2877,
author = {Tiglis Mirela and Neagu Tiberiu Paul and Elfara Mazen and Diaconu Camelia Cristina and Bratu Ovidiu Gabriel and Vacaroiu Ileana Adela and Grintescu Ioana Marina},
title = {Nefopam and its Role in Modulating Acute and Chronic Pain},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2877-2880},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6644},
url = {https://revistadechimie.ro/Articles.asp?ID=6644}
}

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