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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 10, 2899-2903

https://doi.org/10.37358/RC.18.10.6649

Beatrice Rozalina Buca, Liliana Mititelu Tartau, Ciprian Rezus, Cristiana Filip, Alin Constantin Pinzariu, Elena Rezus, Gratiela Eliza Popa, Alina Panainte, Catalina Elena Lupusoru, Maria Bogdan, Liliana Pavel, Raoul Vasile Lupusoru

The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data

Abstract:

We aimed to investigate the effects of two nitric oxide donors in acute inflammation in rats. The experiment was carried out on white Wistar rats, randomly distributed in 4 groups of 5 animals each; the substances were administered intraperitoneally as follows: Group 1 (SS): saline solution 0.1mL/100 g body weight (control); Group 2 (IND): indometacin 150 mg/kg body weight; Group 3 (NEB): nebivolol 1 mg/kg body weight; Group 4 (GSNO): S-nitroso-glutathione 1 mg/kg body weight. An experimental model of acute hind paw inflammation with carrageenan was used for the researches. The influence of the nitric oxide donors on blood parameters, specific inflammatory and immune markers was evaluated 24 h, respectively 72 hours after the injection of irritant agent. The experimental protocol was implemented according to the recommendations of our University Committee for Research and Ethical Issues. The administration of nitric oxide donors nebivolol and S-nitroso-glutathione was accompanied by a substantial diminution of paw edema, as well as by an important decrease in the percent of lymphocytes, a reduction of interleukin 6 and tumor necrosis factor alpha values. The effects of nebivolol were more accentuated than of S-nitroso-glutathione, but less intense than of indomethacin in the experiment. The treatment with nebivolol and S-nitroso-glutathione produced anti-inflammatory effects on local acute inflammation in the carrageenan-induced paw edema test in rats.
Keywords:
Nebivolol; S-Nitroso-glutathione; inflammation; nitric oxide; rats

Issue: 2018, Volume 69, Issue 10
Pages: 2899-2903
Publication date: 2018/11/15
https://doi.org/10.37358/RC.18.10.6649
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BUCA, B.R., TARTAU, L.M., REZUS, C., FILIP, C., PINZARIU, A.C., REZUS, E., POPA, G.E., PANAINTE, A., LUPUSORU, C.E., BOGDAN, M., PAVEL, L., LUPUSORU, R.V., The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data, Rev. Chim., 69(10), 2018, 2899-2903.

Vancouver
Buca BR, Tartau LM, Rezus C, Filip C, Pinzariu AC, Rezus E, Popa GE, Panainte A, Lupusoru CE, Bogdan M, Pavel L, Lupusoru RV. The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data. Rev. Chim.[internet]. 2018 Oct;69(10):2899-2903. Available from: https://doi.org/10.37358/RC.18.10.6649


APA 6th edition
Buca, B.R., Tartau, L.M., Rezus, C., Filip, C., Pinzariu, A.C., Rezus, E.,... Lupusoru, R.V. (2018). The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data. Revista de Chimie, 69(10), 2899-2903. https://doi.org/10.37358/RC.18.10.6649


Harvard
Buca, B.R., Tartau, L.M., Rezus, C., Filip, C., Pinzariu, A.C., Rezus, E., Popa, G.E., Panainte, A., Lupusoru, C.E., Bogdan, M., Pavel, L., Lupusoru, R.V. (2018). 'The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data', Revista de Chimie, 69(10), pp. 2899-2903. https://doi.org/10.37358/RC.18.10.6649


IEEE
B.R. Buca, L.M. Tartau, C. Rezus, C. Filip, A.C. Pinzariu, E. Rezus, G.E. Popa, A. Panainte, C.E. Lupusoru, M. Bogdan, L. Pavel, R.V. Lupusoru, "The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data". Revista de Chimie, vol. 69, no. 10, pp. 2899-2903, 2018. [online]. https://doi.org/10.37358/RC.18.10.6649


Text
Beatrice Rozalina Buca, Liliana Mititelu Tartau, Ciprian Rezus, Cristiana Filip, Alin Constantin Pinzariu, Elena Rezus, Gratiela Eliza Popa, Alina Panainte, Catalina Elena Lupusoru, Maria Bogdan, Liliana Pavel, Raoul Vasile Lupusoru,
The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data,
Revista de Chimie,
Volume 69, Issue 10,
2018,
Pages 2899-2903,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.10.6649.
(https://revistadechimie.ro/Articles.asp?ID=6649)
Keywords: Nebivolol; S-Nitroso-glutathione; inflammation; nitric oxide; rats


RIS
TY - JOUR
T1 - The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data
A1 - Buca, Beatrice Rozalina
A2 - Tartau, Liliana Mititelu
A3 - Rezus, Ciprian
A4 - Filip, Cristiana
A5 - Pinzariu, Alin Constantin
A6 - Rezus, Elena
A7 - Popa, Gratiela Eliza
A8 - Panainte, Alina
A9 - Lupusoru, Catalina Elena
A10 - Bogdan, Maria
A11 - Pavel, Liliana
A12 - Lupusoru, Raoul Vasile
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 10
SP - 2899
EP - 2903
UR - https://doi.org/10.37358/RC.18.10.6649
KW - Nebivolol
KW - S-Nitroso-glutathione
KW - inflammation
KW - nitric oxide
KW - rats
ER -


BibTex
@article{RevCh2018P2899,
author = {Buca Beatrice Rozalina and Tartau Liliana Mititelu and Rezus Ciprian and Filip Cristiana and Pinzariu Alin Constantin and Rezus Elena and Popa Gratiela Eliza and Panainte Alina and Lupusoru Catalina Elena and Bogdan Maria and Pavel Liliana and Lupusoru Raoul Vasile},
title = {The Effects of Two Nitric Oxide Donors in Acute Inflammation in Rats Experimental data},
journal = {Revista de Chimie},
volume = {69},
number = {10},
pages = {2899-2903},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.10.6649},
url = {https://revistadechimie.ro/Articles.asp?ID=6649}
}
 
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