Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers

Tanase, Constantin; Udeanu, Denisa Ioana; Draghici, Constantin; Cocu, Florea

Constantin Tanase, Denisa Ioana Udeanu, Constantin Draghici, Florea Cocu

Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers

Abstract:

1-Ethylamide-, 1-ethanolamide of D-Cloprostenol and their 15-epi-isomers were synthesized by amidation of methyl esters of D-Cloprostenol or 15-epi-Cloprostenol. The crude compounds were purified by pressure chromatography on silica gel and fully characterized by IR, 1H-, 13C-, 2D-NMR (COSY and HETCOR) and MS spectroscopy.

Keywords:
D-Cloprostenol-1-ethylamide; D-Cloprostenol-1-ethanolamide; 15-epi impurities; prostamide; amides; synthesis of amides

Issue: 2018, Volume 69, Issue 12

Pages: 3349-3352

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6747

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TANASE, C., UDEANU, D.I., DRAGHICI, C., COCU, F., Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers, Rev. Chim., 69(12), 2018, 3349-3352.

Vancouver
Tanase C, Udeanu DI, Draghici C, Cocu F. Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers. Rev. Chim.[internet]. 2018 Dec;69(12):3349-3352. Available from: https://doi.org/10.37358/RC.18.12.6747

APA 6th edition
Tanase, C., Udeanu, D.I., Draghici, C. & Cocu, F. (2018). Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers. Revista de Chimie, 69(12), 3349-3352. https://doi.org/10.37358/RC.18.12.6747

Harvard
Tanase, C., Udeanu, D.I., Draghici, C., Cocu, F. (2018). 'Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers', Revista de Chimie, 69(12), pp. 3349-3352. https://doi.org/10.37358/RC.18.12.6747

IEEE
C. Tanase, D.I. Udeanu, C. Draghici, F. Cocu, "Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers". Revista de Chimie, vol. 69, no. 12, pp. 3349-3352, 2018. [online]. https://doi.org/10.37358/RC.18.12.6747

Text
Constantin Tanase, Denisa Ioana Udeanu, Constantin Draghici, Florea Cocu,
Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3349-3352,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6747.
(https://revistadechimie.ro/Articles.asp?ID=6747)
Keywords: D-Cloprostenol-1-ethylamide; D-Cloprostenol-1-ethanolamide; 15-epi impurities; prostamide; amides; synthesis of amides

RIS
TY - JOUR
T1 - Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers
A1 - Tanase, Constantin
A2 - Udeanu, Denisa Ioana
A3 - Draghici, Constantin
A4 - Cocu, Florea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3349
EP - 3352
UR - https://doi.org/10.37358/RC.18.12.6747
KW - D-Cloprostenol-1-ethylamide
KW - D-Cloprostenol-1-ethanolamide
KW - 15-epi impurities
KW - prostamide
KW - amides
KW - synthesis of amides
ER -

BibTex
@article{RevCh2018P3349,
author = {Tanase Constantin and Udeanu Denisa Ioana and Draghici Constantin and Cocu Florea},
title = {Synthesis and Characterization of 1-Ethylamide and 1-Ethanolamide of D-Cloprostenol and their 15-Epimers},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3349-3352},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6747},
url = {https://revistadechimie.ro/Articles.asp?ID=6747}
}

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