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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3416-3422

https://doi.org/10.37358/RC.18.12.6761

Marilena Petrescu, Raul Augustin Mitran, Cristian Matei, Marius Radulescu, Daniela Berger

Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Abstract:

Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.
Keywords:
mesoporous silica; ketoprofen; drug delivery systems; gastric protection; alginate

Issue: 2018, Volume 69, Issue 12
Pages: 3416-3422
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6761
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PETRESCU, M., MITRAN, R.A., MATEI, C., RADULESCU, M., BERGER, D., Silica-Alginate Beads for Intestinal Ketoprofen Delivery, Rev. Chim., 69(12), 2018, 3416-3422.

Vancouver
Petrescu M, Mitran RA, Matei C, Radulescu M, Berger D. Silica-Alginate Beads for Intestinal Ketoprofen Delivery. Rev. Chim.[internet]. 2018 Dec;69(12):3416-3422. Available from: https://doi.org/10.37358/RC.18.12.6761


APA 6th edition
Petrescu, M., Mitran, R.A., Matei, C., Radulescu, M. & Berger, D. (2018). Silica-Alginate Beads for Intestinal Ketoprofen Delivery. Revista de Chimie, 69(12), 3416-3422. https://doi.org/10.37358/RC.18.12.6761


Harvard
Petrescu, M., Mitran, R.A., Matei, C., Radulescu, M., Berger, D. (2018). 'Silica-Alginate Beads for Intestinal Ketoprofen Delivery', Revista de Chimie, 69(12), pp. 3416-3422. https://doi.org/10.37358/RC.18.12.6761


IEEE
M. Petrescu, R.A. Mitran, C. Matei, M. Radulescu, D. Berger, "Silica-Alginate Beads for Intestinal Ketoprofen Delivery". Revista de Chimie, vol. 69, no. 12, pp. 3416-3422, 2018. [online]. https://doi.org/10.37358/RC.18.12.6761


Text
Marilena Petrescu, Raul Augustin Mitran, Cristian Matei, Marius Radulescu, Daniela Berger,
Silica-Alginate Beads for Intestinal Ketoprofen Delivery,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3416-3422,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6761.
(https://revistadechimie.ro/Articles.asp?ID=6761)
Keywords: mesoporous silica; ketoprofen; drug delivery systems; gastric protection; alginate


RIS
TY - JOUR
T1 - Silica-Alginate Beads for Intestinal Ketoprofen Delivery
A1 - Petrescu, Marilena
A2 - Mitran, Raul Augustin
A3 - Matei, Cristian
A4 - Radulescu, Marius
A5 - Berger, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3416
EP - 3422
UR - https://doi.org/10.37358/RC.18.12.6761
KW - mesoporous silica
KW - ketoprofen
KW - drug delivery systems
KW - gastric protection
KW - alginate
ER -


BibTex
@article{RevCh2018P3416,
author = {Petrescu Marilena and Mitran Raul Augustin and Matei Cristian and Radulescu Marius and Berger Daniela},
title = {Silica-Alginate Beads for Intestinal Ketoprofen Delivery},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3416-3422},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6761},
url = {https://revistadechimie.ro/Articles.asp?ID=6761}
}
 
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