The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia

Toth, George; Craina, Marius; Stelea, Lavinia; Citu, Cosmin; Neamtu, Radu; Fogorossy, Atila; Moleriu, Radu Dumitru; Bardan, Razvan; Petre, Izabella; Susan, Razvan; Cheveresan, Adelina; Suciu, Nicolae

George Toth, Marius Craina, Lavinia Stelea, Cosmin Citu, Radu Neamtu, Atila Fogorossy, Radu Dumitru Moleriu, Razvan Bardan, Izabella Petre, Razvan Susan, Adelina Cheveresan, Nicolae Suciu

The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia

Abstract:

Worldwide, 5-8% of pregnant women are diagnosed with preeclampsia. This disease increases the morbidity and mortality of the fetus and pregnant woman, especially in developing countries. Preeclampsia is characterized by systolic blood pressure ] 140mmHg or diastolic blood pressure] 90mmHg as measured twice, and 24 h proteinuria ³0.3 g, after 20 weeks of gestation. The cause of preeclampsia is still incompletely elucidated. Numerous studies have suggested to modernize the definition of preeclampsia by incorporating key biomarkers of either placental or vascular origins, including placental growth factor (PIGF) and antiangiogenic factors such as tyrosine kinase-1 (sFlt-1) in the diagnosis of preeclampsia and the risk of occurrence of the disease in the second trimester of pregnancy [1-5]. We studied a group of 50 patients with a 21-week pregnancy diagnosis, we calculated the ratio between sFlt-1 and PIGF and we tested to see if there was an association between this ratio and the resistivity index (IR) of the uterine artery using the artery Doppler ultrasound. The PIGF level in our group was decreased in women who developed preeclampsia compared to the control group where this problem did not occur. Doppler ultrasound examination during the second trimester of pregnancy may provide extra data for prediction of preeclampsia. Although much of pathophysiology of preeclampsia has been explained, the exact etiology of this disorder remains unclear. It is certain that before the clinical signs of preeclampsia are detectable, there is an imbalance between pro-angiogenic and anti-angiogenic factors.

Keywords:
placental growth factor; tyrosine kinase-1; preeclampsia; uterine artery resistivity index

Issue: 2018, Volume 69, Issue 12

Pages: 3457-3460

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6768

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TOTH, G., CRAINA, M., STELEA, L., CITU, C., NEAMTU, R., FOGOROSSY, A., MOLERIU, R.D., BARDAN, R., PETRE, I., SUSAN, R., CHEVERESAN, A., SUCIU, N., The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia, Rev. Chim., 69(12), 2018, 3457-3460.

Vancouver
Toth G, Craina M, Stelea L, Citu C, Neamtu R, Fogorossy A, Moleriu RD, Bardan R, Petre I, Susan R, Cheveresan A, Suciu N. The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia. Rev. Chim.[internet]. 2018 Dec;69(12):3457-3460. Available from: https://doi.org/10.37358/RC.18.12.6768

APA 6th edition
Toth, G., Craina, M., Stelea, L., Citu, C., Neamtu, R., Fogorossy, A.,... Suciu, N. (2018). The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia. Revista de Chimie, 69(12), 3457-3460. https://doi.org/10.37358/RC.18.12.6768

Harvard
Toth, G., Craina, M., Stelea, L., Citu, C., Neamtu, R., Fogorossy, A., Moleriu, R.D., Bardan, R., Petre, I., Susan, R., Cheveresan, A., Suciu, N. (2018). 'The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia', Revista de Chimie, 69(12), pp. 3457-3460. https://doi.org/10.37358/RC.18.12.6768

IEEE
G. Toth, M. Craina, L. Stelea, C. Citu, R. Neamtu, A. Fogorossy, R.D. Moleriu, R. Bardan, I. Petre, R. Susan, A. Cheveresan, N. Suciu, "The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia". Revista de Chimie, vol. 69, no. 12, pp. 3457-3460, 2018. [online]. https://doi.org/10.37358/RC.18.12.6768

Text
George Toth, Marius Craina, Lavinia Stelea, Cosmin Citu, Radu Neamtu, Atila Fogorossy, Radu Dumitru Moleriu, Razvan Bardan, Izabella Petre, Razvan Susan, Adelina Cheveresan, Nicolae Suciu,
The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3457-3460,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6768.
(https://revistadechimie.ro/Articles.asp?ID=6768)
Keywords: placental growth factor; tyrosine kinase-1; preeclampsia; uterine artery resistivity index

RIS
TY - JOUR
T1 - The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia
A1 - Toth, George
A2 - Craina, Marius
A3 - Stelea, Lavinia
A4 - Citu, Cosmin
A5 - Neamtu, Radu
A6 - Fogorossy, Atila
A7 - Moleriu, Radu Dumitru
A8 - Bardan, Razvan
A9 - Petre, Izabella
A10 - Susan, Razvan
A11 - Cheveresan, Adelina
A12 - Suciu, Nicolae
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3457
EP - 3460
UR - https://doi.org/10.37358/RC.18.12.6768
KW - placental growth factor
KW - tyrosine kinase-1
KW - preeclampsia
KW - uterine artery resistivity index
ER -

BibTex
@article{RevCh2018P3457,
author = {Toth George and Craina Marius and Stelea Lavinia and Citu Cosmin and Neamtu Radu and Fogorossy Atila and Moleriu Radu Dumitru and Bardan Razvan and Petre Izabella and Susan Razvan and Cheveresan Adelina and Suciu Nicolae},
title = {The Association Between Resistivity Index (IR) and the sFlt-1 and PIGF Values in Pregnant Women With Risk of Preeclampsia},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3457-3460},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6768},
url = {https://revistadechimie.ro/Articles.asp?ID=6768}
}

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