Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment

Oancea, Andra; Cobzeanu, Maria Luiza; Tarus, Andrei; Enache, Mihail; Perianu, Lacramioara

Andra Oancea, Maria Luiza Cobzeanu, Andrei Tarus, Mihail Enache, Lacramioara Perianu

Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment

Abstract:

Bioprosthetic heart valves ensure a better quality of life compared to mechanical valves but are prone to degeneration with leaflet calcification and tearing. Valvular leaflets mineralization process is initiated within interstitial cells devitalized by glutaraldehyde with formation of calcium phosphate hydroxyapatite crystals. The aim of the current paper is to analyse early bioprosthetic valve degeneration occurring in three patients that needed bioprosthetic valve explantation and reimplantation of a mechanical valve. The three patients, aged 29, 64 and 78 years presented early degeneration of the implanted valve at 30, 36 and 52 months after the intervention in the context of unavoidable risk factors like young age, chronic kidney disease and small stented valve. Computed tomography examination demonstrated calcifications of the bioprosthetic valve and histological examination confirmed the findings by identifying tissue degeneration with calcification in all cases. Early bioprosthetic valve degeneration is a serious issue in cardiovascular surgery and a major cause of valve failure requiring reintervention. Several methods could be used to delay degeneration like systemic therapy with general anti-calcification agents, the use of locally delivered drugs or tissue pretreatment with special substances (ethanol, nonionic detergents, tridecyl alcohol ethoxylate). No optimal decellularization method for all types of tissues has been yet discovered. In conclusion, early bioprosthetic valve degeneration is a reality that should be taken into account in high risk patients. Current tissue pretreatment with glutaraldehyde is not perfect as it accelerates degeneration with formation of hydroxyapatite calcifications. New methods are needed to achieve efficient decellularization while preserving the functional characteristics of the transplanted tissue.

Keywords:
glutaraldehyde; bioprosthetic valve; degeneration; dysfunction; calcium phosphate hydroxyapatite

Issue: 2018, Volume 69, Issue 12

Pages: 3513-3516

Publication date: 2019/1/15

https://doi.org/10.37358/RC.18.12.6781

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
OANCEA, A., COBZEANU, M.L., TARUS, A., ENACHE, M., PERIANU, L., Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment, Rev. Chim., 69(12), 2018, 3513-3516.

Vancouver
Oancea A, Cobzeanu ML, Tarus A, Enache M, Perianu L. Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment. Rev. Chim.[internet]. 2018 Dec;69(12):3513-3516. Available from: https://doi.org/10.37358/RC.18.12.6781

APA 6th edition
Oancea, A., Cobzeanu, M.L., Tarus, A., Enache, M. & Perianu, L. (2018). Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment. Revista de Chimie, 69(12), 3513-3516. https://doi.org/10.37358/RC.18.12.6781

Harvard
Oancea, A., Cobzeanu, M.L., Tarus, A., Enache, M., Perianu, L. (2018). 'Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment', Revista de Chimie, 69(12), pp. 3513-3516. https://doi.org/10.37358/RC.18.12.6781

IEEE
A. Oancea, M.L. Cobzeanu, A. Tarus, M. Enache, L. Perianu, "Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment". Revista de Chimie, vol. 69, no. 12, pp. 3513-3516, 2018. [online]. https://doi.org/10.37358/RC.18.12.6781

Text
Andra Oancea, Maria Luiza Cobzeanu, Andrei Tarus, Mihail Enache, Lacramioara Perianu,
Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3513-3516,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6781.
(https://revistadechimie.ro/Articles.asp?ID=6781)
Keywords: glutaraldehyde; bioprosthetic valve; degeneration; dysfunction; calcium phosphate hydroxyapatite

RIS
TY - JOUR
T1 - Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment
A1 - Oancea, Andra
A2 - Cobzeanu, Maria Luiza
A3 - Tarus, Andrei
A4 - Enache, Mihail
A5 - Perianu, Lacramioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3513
EP - 3516
UR - https://doi.org/10.37358/RC.18.12.6781
KW - glutaraldehyde
KW - bioprosthetic valve
KW - degeneration
KW - dysfunction
KW - calcium phosphate hydroxyapatite
ER -

BibTex
@article{RevCh2018P3513,
author = {Oancea Andra and Cobzeanu Maria Luiza and Tarus Andrei and Enache Mihail and Perianu Lacramioara},
title = {Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3513-3516},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6781},
url = {https://revistadechimie.ro/Articles.asp?ID=6781}
}

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