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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 12, 3577-3580

https://doi.org/10.37358/RC.18.12.6796

Gabriela Rusu-Zota, Andrei Luca, Gabriela Dumitrita Stanciu, Victorita Sorodoc, Maria Magdalena Leon-Constantin, Bogdan Stoica, Cristina Gales, Teodora Alexa-Stratulat

The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats

Abstract:

Experimental studies and clinical trials revealed the complex interconnections between imidazoline system and various other mediators such as epinephrine, norepinephrine; thus, explain their involvement in the pathophysiological mechanisms of different motor, behavioral and cognitive disturbances. In this study, we tested the influence induced by idazoxan and efaroxan on the cognitive performances in rats. Groups of 6 adult male Wistar rats were treated intraperitoneally according to the following protocol: group I (Control): distilled water 0.3 ml/100g; group II (IDZ): 3 mg/kg idazoxan and group III (EFR): 1 mg/kg efaroxan. The effects of the imidazoline receptor antagonists on the rats cognitive functions were assessed using the radial-arm maze, in order to count the time spent into the arms, the number of baited arms visited, but previously explored (working memory errors); the time taken to consume all baits and the number of entering in non-baited arms (reference memory errors). The data were expressed as mean +/- standard deviation, and statistically analyzed using SPSS version 17.0 Software for Windows, followed by ANOVA one-way method. The administration of IDZ, as well as of EFR was accompanied by a substantial diminution in the number of working memory errors, and the period of time to consume all baits, statistically significant (p[0.01) compared to control group. The use of these two imidazoline receptors antagonists resulted in a considerable decrease in the reference memory errors number, statistically significant (p[0.01) compared to the group treated with distilled water. The influence of IDZ on the evaluated parameters was more accentuated than the effects induced by EFR in all sessions of testing, in this behavioral experimental model. Our findings indicate that treatment with both imidazoline receptor antagonists, idazoxan and efaroxan was associated by a facilitation of the short-term memory retention, an enhancement of discriminative spatial learning, and an improvement of long-term memory performance in radial arm maze in rats.
Keywords:
imidazoline receptors antagonists; spatial and reference memory; rats

Issue: 2018, Volume 69, Issue 12
Pages: 3577-3580
Publication date: 2019/1/15
https://doi.org/10.37358/RC.18.12.6796
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
RUSU-ZOTA, G., LUCA, A., STANCIU, G.D., SORODOC, V., LEON-CONSTANTIN, M.M., STOICA, B., GALES, C., ALEXA-STRATULAT, T., The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats, Rev. Chim., 69(12), 2018, 3577-3580.

Vancouver
Rusu-Zota G, Luca A, Stanciu GD, Sorodoc V, Leon-Constantin MM, Stoica B, Gales C, Alexa-Stratulat T. The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats. Rev. Chim.[internet]. 2018 Dec;69(12):3577-3580. Available from: https://doi.org/10.37358/RC.18.12.6796


APA 6th edition
Rusu-Zota, G., Luca, A., Stanciu, G.D., Sorodoc, V., Leon-Constantin, M.M., Stoica, B., Gales, C. & Alexa-Stratulat, T. (2018). The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats. Revista de Chimie, 69(12), 3577-3580. https://doi.org/10.37358/RC.18.12.6796


Harvard
Rusu-Zota, G., Luca, A., Stanciu, G.D., Sorodoc, V., Leon-Constantin, M.M., Stoica, B., Gales, C., Alexa-Stratulat, T. (2018). 'The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats', Revista de Chimie, 69(12), pp. 3577-3580. https://doi.org/10.37358/RC.18.12.6796


IEEE
G. Rusu-Zota, A. Luca, G.D. Stanciu, V. Sorodoc, M.M. Leon-Constantin, B. Stoica, C. Gales, T. Alexa-Stratulat, "The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats". Revista de Chimie, vol. 69, no. 12, pp. 3577-3580, 2018. [online]. https://doi.org/10.37358/RC.18.12.6796


Text
Gabriela Rusu-Zota, Andrei Luca, Gabriela Dumitrita Stanciu, Victorita Sorodoc, Maria Magdalena Leon-Constantin, Bogdan Stoica, Cristina Gales, Teodora Alexa-Stratulat,
The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats,
Revista de Chimie,
Volume 69, Issue 12,
2018,
Pages 3577-3580,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.12.6796.
(https://revistadechimie.ro/Articles.asp?ID=6796)
Keywords: imidazoline receptors antagonists; spatial and reference memory; rats


RIS
TY - JOUR
T1 - The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats
A1 - Rusu-Zota, Gabriela
A2 - Luca, Andrei
A3 - Stanciu, Gabriela Dumitrita
A4 - Sorodoc, Victorita
A5 - Leon-Constantin, Maria Magdalena
A6 - Stoica, Bogdan
A7 - Gales, Cristina
A8 - Alexa-Stratulat, Teodora
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 12
SP - 3577
EP - 3580
UR - https://doi.org/10.37358/RC.18.12.6796
KW - imidazoline receptors antagonists
KW - spatial and reference memory
KW - rats
ER -


BibTex
@article{RevCh2018P3577,
author = {Rusu-Zota Gabriela and Luca Andrei and Stanciu Gabriela Dumitrita and Sorodoc Victorita and Leon-Constantin Maria Magdalena and Stoica Bogdan and Gales Cristina and Alexa-Stratulat Teodora},
title = {The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats},
journal = {Revista de Chimie},
volume = {69},
number = {12},
pages = {3577-3580},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.12.6796},
url = {https://revistadechimie.ro/Articles.asp?ID=6796}
}
 
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