Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression

Zaha, Dana Carmen; Jurca, Claudia Maria; Bungau, Simona; Cioca, Gabriela; Popa, Amorin; Sava, Cristian; Endres, Laura; Vesa, Cosmin Mihai

Dana Carmen Zaha, Claudia Maria Jurca, Simona Bungau, Gabriela Cioca, Amorin Popa, Cristian Sava, Laura Endres, Cosmin Mihai Vesa

Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression

Abstract:

We investigated the immunohistochemical expression of E-cadherin (product of CDH1 gene) and its correlation with clinical-pathological parameters and survival rate in the molecular groups of breast cancer. Our study included female breast cancer patients diagnosed at the Municipal Emergency Clinical Hospital Timisoara followed up five years since diagnosis using formalin fixed paraffin embedded tissue. The traditional prognostic factors (age, tumor size, histological type, histological grade, anatomical status of the lymph nodes) were abstracted from histopathology reports and we set prognostic index (the Nothingham and lymph-node prognosis index). Molecular classification on selected cases was performed in agreement with data from the literature: luminal A, B, HER2+, triple-negative. We noted positive (membranar) expressions in 43 cases (70.49 %). Negative immunoreactions for E-cadherin have been observed in all cases of lobular carcinomas (4 cases), as well as 6 cases of mixed carcinomas. A significant correlation was found between E-cadherin expression and hormonal status, tumor size, histologic type, tumor grade and molecular subtype. Most of the luminal A and B tumors were E-cadherin positive, while more than half of non-luminal tumors were E-cadherin negative. Survival rates are different in the negative and positive E-cadherin tumor groups respectively and between luminal and non-luminal groups. E-cadherin expression may be a useful prognostic marker for classifying other subgroups of breast cancer.

Keywords:
CDH1; breast cancer; immunohistochemistry; E-Cadherin

Issue: 2019, Volume 70, Issue 2

Pages: 465-469

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6936

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ZAHA, D.C., JURCA, C.M., BUNGAU, S., CIOCA, G., POPA, A., SAVA, C., ENDRES, L., VESA, C.M., Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression, Rev. Chim., 70(2), 2019, 465-469.

Vancouver
Zaha DC, Jurca CM, Bungau S, Cioca G, Popa A, Sava C, Endres L, Vesa CM. Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression. Rev. Chim.[internet]. 2019 Feb;70(2):465-469. Available from: https://doi.org/10.37358/RC.19.2.6936

APA 6th edition
Zaha, D.C., Jurca, C.M., Bungau, S., Cioca, G., Popa, A., Sava, C., Endres, L. & Vesa, C.M. (2019). Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression. Revista de Chimie, 70(2), 465-469. https://doi.org/10.37358/RC.19.2.6936

Harvard
Zaha, D.C., Jurca, C.M., Bungau, S., Cioca, G., Popa, A., Sava, C., Endres, L., Vesa, C.M. (2019). 'Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression', Revista de Chimie, 70(2), pp. 465-469. https://doi.org/10.37358/RC.19.2.6936

IEEE
D.C. Zaha, C.M. Jurca, S. Bungau, G. Cioca, A. Popa, C. Sava, L. Endres, C.M. Vesa, "Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression". Revista de Chimie, vol. 70, no. 2, pp. 465-469, 2019. [online]. https://doi.org/10.37358/RC.19.2.6936

Text
Dana Carmen Zaha, Claudia Maria Jurca, Simona Bungau, Gabriela Cioca, Amorin Popa, Cristian Sava, Laura Endres, Cosmin Mihai Vesa,
Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 465-469,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6936.
(https://revistadechimie.ro/Articles.asp?ID=6936)
Keywords: CDH1; breast cancer; immunohistochemistry; E-Cadherin

RIS
TY - JOUR
T1 - Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression
A1 - Zaha, Dana Carmen
A2 - Jurca, Claudia Maria
A3 - Bungau, Simona
A4 - Cioca, Gabriela
A5 - Popa, Amorin
A6 - Sava, Cristian
A7 - Endres, Laura
A8 - Vesa, Cosmin Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 465
EP - 469
UR - https://doi.org/10.37358/RC.19.2.6936
KW - CDH1
KW - breast cancer
KW - immunohistochemistry
KW - E-Cadherin
ER -

BibTex
@article{RevCh2019P465,
author = {Zaha Dana Carmen and Jurca Claudia Maria and Bungau Simona and Cioca Gabriela and Popa Amorin and Sava Cristian and Endres Laura and Vesa Cosmin Mihai},
title = {Luminal Versus Non-luminal Breast Cancer CDH1 Immunohistochemical Expression},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {465-469},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6936},
url = {https://revistadechimie.ro/Articles.asp?ID=6936}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)