Visible Spectrophotometric Analysis Method of  Sodium Metamizole in Tablets

Gavat, Cristian Catalin; Vasilescu, Leonard Vasile; Marculescu, Afrodita Doina

Cristian Catalin Gavat, Leonard Vasile Vasilescu, Afrodita Doina Marculescu

Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets

Abstract:

The aim of this research was to exactly quantify pure sodium metamizole from tablets , using a spectrophotometric analysis in Visible range. The method applied has been subjected to a validation protocal which consisted in analyzing the following parameters: linearity of the method, detection limit (LD) , quantitation limit (LQ), Sandell’s sensitivity, interference of excipients, stability of prepared solutions, method and system precision, accuracy of the method. Following actual dosing, pure sodium metamizole amount in tablet of pharmaceutical was found to be 477.477 mg assigned to a percentage content of 95.495 %, very close to official declared amount (500 mg), with an maximum average percentage deviation of only 4.505 % from the official declared active substance content. This value was situated below the maximum admissible percentage deviation from stated active substance content (± 5%), established by Romanian Pharmacopoeia, X-th Edition rules.

Keywords:
sodium metamizole; analgesic action; validation protocol; detection limit; quantitation limit

Issue: 2019, Volume 70, Issue 2

Pages: 475-482

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6938

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GAVAT, C.C., VASILESCU, L.V., MARCULESCU, A.D., Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets, Rev. Chim., 70(2), 2019, 475-482.

Vancouver
Gavat CC, Vasilescu LV, Marculescu AD. Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets. Rev. Chim.[internet]. 2019 Feb;70(2):475-482. Available from: https://doi.org/10.37358/RC.19.2.6938

APA 6th edition
Gavat, C.C., Vasilescu, L.V. & Marculescu, A.D. (2019). Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets. Revista de Chimie, 70(2), 475-482. https://doi.org/10.37358/RC.19.2.6938

Harvard
Gavat, C.C., Vasilescu, L.V., Marculescu, A.D. (2019). 'Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets', Revista de Chimie, 70(2), pp. 475-482. https://doi.org/10.37358/RC.19.2.6938

IEEE
C.C. Gavat, L.V. Vasilescu, A.D. Marculescu, "Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets". Revista de Chimie, vol. 70, no. 2, pp. 475-482, 2019. [online]. https://doi.org/10.37358/RC.19.2.6938

Text
Cristian Catalin Gavat, Leonard Vasile Vasilescu, Afrodita Doina Marculescu,
Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 475-482,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6938.
(https://revistadechimie.ro/Articles.asp?ID=6938)
Keywords: sodium metamizole; analgesic action; validation protocol; detection limit; quantitation limit

RIS
TY - JOUR
T1 - Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets
A1 - Gavat, Cristian Catalin
A2 - Vasilescu, Leonard Vasile
A3 - Marculescu, Afrodita Doina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 475
EP - 482
UR - https://doi.org/10.37358/RC.19.2.6938
KW - sodium metamizole
KW - analgesic action
KW - validation protocol
KW - detection limit
KW - quantitation limit
ER -

BibTex
@article{RevCh2019P475,
author = {Gavat Cristian Catalin and Vasilescu Leonard Vasile and Marculescu Afrodita Doina},
title = {Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {475-482},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6938},
url = {https://revistadechimie.ro/Articles.asp?ID=6938}
}

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