Raspunsul gazdei la hepatita cronica virala B

Cringus, Laura-Ioana; Petrescu, Florin; Calborean, Veronica; Rotaru, Luciana Teodora; Marginean, Cristina; Mesina, Cristian; Bunescu, Marius Gabriel; Dinescu, Venera Cristina; Gheorman, Victor; Dijmarescu, Anda Lorena; Udristoiu, Ion; Ciobanu, Daniela

Laura-Ioana Cringus, Florin Petrescu, Veronica Calborean, Luciana Teodora Rotaru, Cristina Marginean, Cristian Mesina, Marius Gabriel Bunescu, Venera Cristina Dinescu, Victor Gheorman, Anda Lorena Dijmarescu, Ion Udristoiu, Daniela Ciobanu

Raspunsul gazdei la hepatita cronica virala B

Abstract:

This review discusses and tries to demonstrate the importance of proinflammatory and antiinflammatory cytokines in HBV infection. Hepatitis B virus is a virus that is both hepatotropic and non-cytopathic. It causes the development of liver diseases which could progress into both acute and chronic versions. The virus is very widespread and results in the death of quite a number of people each year. The outcome of the viral infection is a result of immunologically mediated event. This means that the outcome is determined by the response of the immune system of the host. The infection can lead to several different liver diseases as well as fibrosis and cirrhosis. When an infection occurs, there is an attempt by the body to fight it via the use of several mechanisms. One of these is the use of cytokines (which are proteins). There exist different kinds of cytokines of which interleukin-10 and interferon gamma are very important. Interleukin-10 is an anti-inflammatory cytokine which inhibits the effector mechanism of Th1 cytokines. It performs hepatoprotective and anti-inflammatory functions and also upregulates Th2 cytokines. The function and relevance of this cytokine in the pathogenesis of liver diseases cannot be underemphasized. Interferon gamma, on the other hand, is a pro-inflammatory cytokine which seeks to eliminate and expunge the virus from the liver upon infection. It does this by congregating at the site of infection which subsequently results in inflammation and eventually liver fibrosis. This effect could be reversed by administering another type of interferon; interferon alpha.

Keywords:
cytokines; Hepatitis B virus; liver diseases; fibrosis; cirrhosis; interleukin-10

Issue: 2019, Volume 70, Issue 2

Pages: 646-650

Publication date: 2019/3/15

https://doi.org/10.37358/RC.19.2.6976

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CRINGUS, L., PETRESCU, F., CALBOREAN, V., ROTARU, L.T., MARGINEAN, C., MESINA, C., BUNESCU, M.G., DINESCU, V.C., GHEORMAN, V., DIJMARESCU, A.L., UDRISTOIU, I., CIOBANU, D., Raspunsul gazdei la hepatita cronica virala B, Rev. Chim., 70(2), 2019, 646-650.

Vancouver
Cringus L, Petrescu F, Calborean V, Rotaru LT, Marginean C, Mesina C, Bunescu MG, Dinescu VC, Gheorman V, Dijmarescu AL, Udristoiu I, Ciobanu D. Raspunsul gazdei la hepatita cronica virala B. Rev. Chim.[internet]. 2019 Feb;70(2):646-650. Available from: https://doi.org/10.37358/RC.19.2.6976

APA 6th edition
Cringus, L., Petrescu, F., Calborean, V., Rotaru, L.T., Marginean, C., Mesina, C.,... Ciobanu, D. (2019). Raspunsul gazdei la hepatita cronica virala B. Revista de Chimie, 70(2), 646-650. https://doi.org/10.37358/RC.19.2.6976

Harvard
Cringus, L., Petrescu, F., Calborean, V., Rotaru, L.T., Marginean, C., Mesina, C., Bunescu, M.G., Dinescu, V.C., Gheorman, V., Dijmarescu, A.L., Udristoiu, I., Ciobanu, D. (2019). 'Raspunsul gazdei la hepatita cronica virala B', Revista de Chimie, 70(2), pp. 646-650. https://doi.org/10.37358/RC.19.2.6976

IEEE
L. Cringus, F. Petrescu, V. Calborean, L.T. Rotaru, C. Marginean, C. Mesina, M.G. Bunescu, V.C. Dinescu, V. Gheorman, A.L. Dijmarescu, I. Udristoiu, D. Ciobanu, "Raspunsul gazdei la hepatita cronica virala B". Revista de Chimie, vol. 70, no. 2, pp. 646-650, 2019. [online]. https://doi.org/10.37358/RC.19.2.6976

Text
Laura-Ioana Cringus, Florin Petrescu, Veronica Calborean, Luciana Teodora Rotaru, Cristina Marginean, Cristian Mesina, Marius Gabriel Bunescu, Venera Cristina Dinescu, Victor Gheorman, Anda Lorena Dijmarescu, Ion Udristoiu, Daniela Ciobanu,
Raspunsul gazdei la hepatita cronica virala B,
Revista de Chimie,
Volume 70, Issue 2,
2019,
Pages 646-650,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.2.6976.
(https://revistadechimie.ro/Articles.asp?ID=6976)
Keywords: cytokines; Hepatitis B virus; liver diseases; fibrosis; cirrhosis; interleukin-10

RIS
TY - JOUR
T1 - Raspunsul gazdei la hepatita cronica virala B
A1 - Cringus, Laura-Ioana
A2 - Petrescu, Florin
A3 - Calborean, Veronica
A4 - Rotaru, Luciana Teodora
A5 - Marginean, Cristina
A6 - Mesina, Cristian
A7 - Bunescu, Marius Gabriel
A8 - Dinescu, Venera Cristina
A9 - Gheorman, Victor
A10 - Dijmarescu, Anda Lorena
A11 - Udristoiu, Ion
A12 - Ciobanu, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 2
SP - 646
EP - 650
UR - https://doi.org/10.37358/RC.19.2.6976
KW - cytokines
KW - Hepatitis B virus
KW - liver diseases
KW - fibrosis
KW - cirrhosis
KW - interleukin-10
ER -

BibTex
@article{RevCh2019P646,
author = {Cringus Laura-Ioana and Petrescu Florin and Calborean Veronica and Rotaru Luciana Teodora and Marginean Cristina and Mesina Cristian and Bunescu Marius Gabriel and Dinescu Venera Cristina and Gheorman Victor and Dijmarescu Anda Lorena and Udristoiu Ion and Ciobanu Daniela},
title = {Raspunsul gazdei la hepatita cronica virala B},
journal = {Revista de Chimie},
volume = {70},
number = {2},
pages = {646-650},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.2.6976},
url = {https://revistadechimie.ro/Articles.asp?ID=6976}
}

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