Cytogenetic Study of Spontaneous Abortions in the Western part of Romania

Farcas, Simona; Andreescu, Nicoleta; Amzar, Daniela; Stelea, Lavinia; Mihailescu, Alexandra; Dobrescu, Andreea; Meszaros, Noemi

Simona Farcas, Nicoleta Andreescu, Daniela Amzar, Lavinia Stelea, Alexandra Mihailescu, Andreea Dobrescu, Noemi Meszaros

Cytogenetic Study of Spontaneous Abortions in the Western part of Romania

Abstract:

Regarding the rate of chromosomal abnormalities in spontaneous abortions, the data varies between 50 and 80% for first trimester miscarriages but there are several factors that may influence the rate of chromosomal aberrations as the selection bias of the cases for which cytogenetic analysis is done, the gestational age distribution, the maternal age distribution, the tissue samples analyzed, the expertise in cytogenetic methods. The aim of the research is to establish the incidence of chromosomal aberration in our study lot for the patients from the Western part of Romania, as there are no studies available for this specific population. In the present study, patients were included with pregnancy loss between 4 to 14 weeks of gestation for whom cytogenetic evaluation of the fetus was done in the University of Medicine and Pharmacy Timisoara. Of all results, 48.57% (34 out of 70) aborted fetuses had an abnormal karyotype. The gestational age of the aborted fetuses varied between 5 and 14 weeks of gestation, with a mean of 8.95 weeks of gestation. A higher incidence of chromosomal anomalies was observed in the group including patients ³ 35 years as compared with the group patients aged under 35 years old (55.5% vs 45.5%). The results of cytogenetic analysis of first trimester miscarriage is an important tool that can enhance diagnostic evaluation, and represent a critical information for counselling infertile couples. Post-miscarriage genetic and psychological counselling and appropriate treatment are crucial for the prevention of high psychological distress, psychiatric symptoms and psychopathology in these patients.

Keywords:
cytogenetic analysis; spontaneous abortions; infertility

Issue: 2019, Volume 70, Issue 3

Pages: 1000-1004

Publication date: 2019/4/15

https://doi.org/10.37358/RC.19.3.7049

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FARCAS, S., ANDREESCU, N., AMZAR, D., STELEA, L., MIHAILESCU, A., DOBRESCU, A., MESZAROS, N., Cytogenetic Study of Spontaneous Abortions in the Western part of Romania, Rev. Chim., 70(3), 2019, 1000-1004.

Vancouver
Farcas S, Andreescu N, Amzar D, Stelea L, Mihailescu A, Dobrescu A, Meszaros N. Cytogenetic Study of Spontaneous Abortions in the Western part of Romania. Rev. Chim.[internet]. 2019 Mar;70(3):1000-1004. Available from: https://doi.org/10.37358/RC.19.3.7049

APA 6th edition
Farcas, S., Andreescu, N., Amzar, D., Stelea, L., Mihailescu, A., Dobrescu, A. & Meszaros, N. (2019). Cytogenetic Study of Spontaneous Abortions in the Western part of Romania. Revista de Chimie, 70(3), 1000-1004. https://doi.org/10.37358/RC.19.3.7049

Harvard
Farcas, S., Andreescu, N., Amzar, D., Stelea, L., Mihailescu, A., Dobrescu, A., Meszaros, N. (2019). 'Cytogenetic Study of Spontaneous Abortions in the Western part of Romania', Revista de Chimie, 70(3), pp. 1000-1004. https://doi.org/10.37358/RC.19.3.7049

IEEE
S. Farcas, N. Andreescu, D. Amzar, L. Stelea, A. Mihailescu, A. Dobrescu, N. Meszaros, "Cytogenetic Study of Spontaneous Abortions in the Western part of Romania". Revista de Chimie, vol. 70, no. 3, pp. 1000-1004, 2019. [online]. https://doi.org/10.37358/RC.19.3.7049

Text
Simona Farcas, Nicoleta Andreescu, Daniela Amzar, Lavinia Stelea, Alexandra Mihailescu, Andreea Dobrescu, Noemi Meszaros,
Cytogenetic Study of Spontaneous Abortions in the Western part of Romania,
Revista de Chimie,
Volume 70, Issue 3,
2019,
Pages 1000-1004,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.3.7049.
(https://revistadechimie.ro/Articles.asp?ID=7049)
Keywords: cytogenetic analysis; spontaneous abortions; infertility

RIS
TY - JOUR
T1 - Cytogenetic Study of Spontaneous Abortions in the Western part of Romania
A1 - Farcas, Simona
A2 - Andreescu, Nicoleta
A3 - Amzar, Daniela
A4 - Stelea, Lavinia
A5 - Mihailescu, Alexandra
A6 - Dobrescu, Andreea
A7 - Meszaros, Noemi
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 3
SP - 1000
EP - 1004
UR - https://doi.org/10.37358/RC.19.3.7049
KW - cytogenetic analysis
KW - spontaneous abortions
KW - infertility
ER -

BibTex
@article{RevCh2019P1000,
author = {Farcas Simona and Andreescu Nicoleta and Amzar Daniela and Stelea Lavinia and Mihailescu Alexandra and Dobrescu Andreea and Meszaros Noemi},
title = {Cytogenetic Study of Spontaneous Abortions in the Western part of Romania},
journal = {Revista de Chimie},
volume = {70},
number = {3},
pages = {1000-1004},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.3.7049},
url = {https://revistadechimie.ro/Articles.asp?ID=7049}
}

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