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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 4, 1251-1257

https://doi.org/10.37358/RC.19.4.7103

Beatriz Tamargo Santos, Simona Bungau, Catherine Fleitas Perez, Yanet Marquez Napoles, Juan F. Infante Bourzac, Reinaldo Oliva Hernandez, Wendy Ramirez Gonzalez, Gabriela Cioca, Lotfi Aleya, V. Gustavo Sierra Gonzalez

Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide

Abstract:

The proteoliposomes and cochleates are used as adjuvants for vaccines since they are potent immune stimulators. However, the hyper stimulation of the immune system provoked by adjuvants can cause immune-toxicological side effects. The present study was carried out to evaluate the toxic and immuno-toxicological effects of new adjuvants for anti-meningococci vaccines based on neo-proteoliposomes (nPL) and neo-cochleates (nCh), in Balb/c mice that were administered doses of 15 µg each, over periods of 14 days through intramuscular route and three inoculations with the same doses through intranasal route, every 7 days. The Scanning and Transmission Electron Microscopy showed that the nPL and nCh had nanometric dimensions and their normal peculiar forms. The experimental formulations did not provoke general toxic effects in the tested animals, which tended to the progressive normal growing of this species, that did not statistically differ from the control ones. The studies of pathologic anatomy in inoculation organs and sites did not reveal modifications that can indicate toxicity and there was no sign of hepatic damage. The structural observations found in the spleen and lymphatic nodes showed the physiological development of the immune response, which was normal in all cases showing the restitution of the stimulation signs. The relative weight values of the spleen were within the standard range. These results showed that the nPL and nCh elaborated as adjuvants for vaccines did not show any evident induction of general toxic or particular immune-toxicologicl effects.
Keywords:
immunotoxicology; adjuvants; nanoparticles; cochleates; proteoliposomes

Issue: 2019, Volume 70, Issue 4
Pages: 1251-1257
Publication date: 2019/5/15
https://doi.org/10.37358/RC.19.4.7103
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SANTOS, B.T., BUNGAU, S., PEREZ, C.F., NAPOLES, Y.M., BOURZAC, J.F.I., HERNANDEZ, R.O., GONZALEZ, W.R., CIOCA, G., ALEYA, L., GONZALEZ, V.G.S., Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide, Rev. Chim., 70(4), 2019, 1251-1257.

Vancouver
Santos BT, Bungau S, Perez CF, Napoles YM, Bourzac JFI, Hernandez RO, Gonzalez WR, Cioca G, Aleya L, Gonzalez VGS. Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide. Rev. Chim.[internet]. 2019 Apr;70(4):1251-1257. Available from: https://doi.org/10.37358/RC.19.4.7103


APA 6th edition
Santos, B.T., Bungau, S., Perez, C.F., Napoles, Y.M., Bourzac, J.F.I., Hernandez, R.O.,... Gonzalez, V.G.S. (2019). Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide. Revista de Chimie, 70(4), 1251-1257. https://doi.org/10.37358/RC.19.4.7103


Harvard
Santos, B.T., Bungau, S., Perez, C.F., Napoles, Y.M., Bourzac, J.F.I., Hernandez, R.O., Gonzalez, W.R., Cioca, G., Aleya, L., Gonzalez, V.G.S. (2019). 'Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide', Revista de Chimie, 70(4), pp. 1251-1257. https://doi.org/10.37358/RC.19.4.7103


IEEE
B.T. Santos, S. Bungau, C.F. Perez, Y.M. Napoles, J.F.I. Bourzac, R.O. Hernandez, W.R. Gonzalez, G. Cioca, L. Aleya, V.G.S. Gonzalez, "Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide". Revista de Chimie, vol. 70, no. 4, pp. 1251-1257, 2019. [online]. https://doi.org/10.37358/RC.19.4.7103


Text
Beatriz Tamargo Santos, Simona Bungau, Catherine Fleitas Perez, Yanet Marquez Napoles, Juan F. Infante Bourzac, Reinaldo Oliva Hernandez, Wendy Ramirez Gonzalez, Gabriela Cioca, Lotfi Aleya, V. Gustavo Sierra Gonzalez,
Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1251-1257,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7103.
(https://revistadechimie.ro/Articles.asp?ID=7103)
Keywords: immunotoxicology; adjuvants; nanoparticles; cochleates; proteoliposomes


RIS
TY - JOUR
T1 - Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide
A1 - Santos, Beatriz Tamargo
A2 - Bungau, Simona
A3 - Perez, Catherine Fleitas
A4 - Napoles, Yanet Marquez
A5 - Bourzac, Juan F. Infante
A6 - Hernandez, Reinaldo Oliva
A7 - Gonzalez, Wendy Ramirez
A8 - Cioca, Gabriela
A9 - Aleya, Lotfi
A10 - Gonzalez, V. Gustavo Sierra
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1251
EP - 1257
UR - https://doi.org/10.37358/RC.19.4.7103
KW - immunotoxicology
KW - adjuvants
KW - nanoparticles
KW - cochleates
KW - proteoliposomes
ER -


BibTex
@article{RevCh2019P1251,
author = {Santos Beatriz Tamargo and Bungau Simona and Perez Catherine Fleitas and Napoles Yanet Marquez and Bourzac Juan F. Infante and Hernandez Reinaldo Oliva and Gonzalez Wendy Ramirez and Cioca Gabriela and Aleya Lotfi and Gonzalez V. Gustavo Sierra},
title = {Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1251-1257},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7103},
url = {https://revistadechimie.ro/Articles.asp?ID=7103}
}
 
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