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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 4, 1315-1318

https://doi.org/10.37358/RC.19.4.7117

Mihaela Balaban, Bogdana Virgolici, Adriana Dinu, Alexandra Totan, Daniela Miricescu, Daciana Stefan, Maria Greabu, Maria Mohora

Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles

Abstract:

Glucocorticosteroids are the mainstay of treatment in many inflammatory and autoimmune disorders. Their administration can be associated with various side effects, similar to those within the metabolic syndrome. The beneficial effects of vitamin E in metabolic syndrome were demonstrated by many studies. Nowadays, vitamin E can be administrated through a new and innovative system delivery, such as polylactic-co-glycolic acid nanoparticles (PLGA-NPs). The aim of this experimental study was to compare the metabolic and haematological parameters after Prednisone administration as a single drug or in combination with vitamin E delivered by PLGA-NPs. Wistar male rats (n=15, age 10-12 months), on standard diet were randomised in three groups, for 6 weeks as: group SC served as a control, group SP was treated with Prednisone (1 mg/kg/day) by oral gavage and group SN received Prednisone (1 mg/kg/day) and vitamin E-charged PLGA nanoparticles (1 mg/kg/day) by oral gavage. In the Prednison treated group versus control, higher levels (p[0.05) were demonstrated for visceral fat weight, glycosylated hemoglobin (HbA1c), cholesterolemia and triglyceridemia. The association of PLGA-NPs charged with vitamin E to Prednisone prevented (p[0.05) hypercholesterolemia and visceral fat development induced by the cortisol intake. In conclusion, polylactic-co-glycolic acid nanoparticles (PLGA-NPs) charged with Vitamin E may demonstrate promising results in decreasing side effects induced by glucocorticosteroids, by reducing the amount of visceral fat and cholesterolemia.
Keywords:
prednisone; vitamin E-charged PLGA nanoparticles; Wistar rats

Issue: 2019, Volume 70, Issue 4
Pages: 1315-1318
Publication date: 2019/5/15
https://doi.org/10.37358/RC.19.4.7117
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BALABAN, M., VIRGOLICI, B., DINU, A., TOTAN, A., MIRICESCU, D., STEFAN, D., GREABU, M., MOHORA, M., Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles, Rev. Chim., 70(4), 2019, 1315-1318.

Vancouver
Balaban M, Virgolici B, Dinu A, Totan A, Miricescu D, Stefan D, Greabu M, Mohora M. Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles. Rev. Chim.[internet]. 2019 Apr;70(4):1315-1318. Available from: https://doi.org/10.37358/RC.19.4.7117


APA 6th edition
Balaban, M., Virgolici, B., Dinu, A., Totan, A., Miricescu, D., Stefan, D., Greabu, M. & Mohora, M. (2019). Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles. Revista de Chimie, 70(4), 1315-1318. https://doi.org/10.37358/RC.19.4.7117


Harvard
Balaban, M., Virgolici, B., Dinu, A., Totan, A., Miricescu, D., Stefan, D., Greabu, M., Mohora, M. (2019). 'Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles', Revista de Chimie, 70(4), pp. 1315-1318. https://doi.org/10.37358/RC.19.4.7117


IEEE
M. Balaban, B. Virgolici, A. Dinu, A. Totan, D. Miricescu, D. Stefan, M. Greabu, M. Mohora, "Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles". Revista de Chimie, vol. 70, no. 4, pp. 1315-1318, 2019. [online]. https://doi.org/10.37358/RC.19.4.7117


Text
Mihaela Balaban, Bogdana Virgolici, Adriana Dinu, Alexandra Totan, Daniela Miricescu, Daciana Stefan, Maria Greabu, Maria Mohora,
Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1315-1318,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7117.
(https://revistadechimie.ro/Articles.asp?ID=7117)
Keywords: prednisone; vitamin E-charged PLGA nanoparticles; Wistar rats


RIS
TY - JOUR
T1 - Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles
A1 - Balaban, Mihaela
A2 - Virgolici, Bogdana
A3 - Dinu, Adriana
A4 - Totan, Alexandra
A5 - Miricescu, Daniela
A6 - Stefan, Daciana
A7 - Greabu, Maria
A8 - Mohora, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1315
EP - 1318
UR - https://doi.org/10.37358/RC.19.4.7117
KW - prednisone; vitamin E-charged PLGA nanoparticles; Wistar rats
ER -


BibTex
@article{RevCh2019P1315,
author = {Balaban Mihaela and Virgolici Bogdana and Dinu Adriana and Totan Alexandra and Miricescu Daniela and Stefan Daciana and Greabu Maria and Mohora Maria},
title = {Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1315-1318},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7117},
url = {https://revistadechimie.ro/Articles.asp?ID=7117}
}
 
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