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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 4, 1396-1398

https://doi.org/10.37358/RC.19.4.7135

Alexandra Totan, Andra-Elena Balcangiu-Stroescu, Marina Melescanu Imre, Daniela Miricescu, Daniela Balan, Iulia-Ioana Stanescu, Dorin Ionescu, Delia Timofte, Maria Daniela Tanasescu, Maria Greabu

XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease

Abstract:

Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species. The aim of our study was to investigate possible correlations of XOR serum levels with oxidative stress (total antioxidant capacity - TAC, anti-oxidative stress responsive 1 antibody - OXSR1) and inflammation markers (interleukin 6 - IL-6), in 20 hemodialysis diabetic patients. The present study included the hemodialysis diabetic patients group (10 males and 10 females) and the control group (20 healthy volunteers). For serum XOR (ng/mL), TAC (U/mL) and OXSR1 (ng/ml) measurements we have used the ELISA technique. Serum IL6 (pg/mL) was performed using an automatic immunoassay system (Immulite 1000, Siemens- Germany). Comparing the two groups, our results revealed significantly increased serum levels for XOR (6.2±1.5 / 3.9±1.1); OXSR1 (11.3±2.9 / 6.2±2.1) and IL6 (7.0±1.2 / 5.0±0.4). Patients’ serum levels of TAC were significantly decreased compared with the control group values (25.2±3.9 / 33.5±2.8). It becomes more and more obvious that oxidative stress is an important element initiating diabetic microvascular complications, including diabetic kidney disease. Our results suggested that XOR should be regarded as an important target in the attempt to reduce oxidative stress in the context of diabetic kidney disease.
Keywords:
xanthine oxidoreductase; oxidative stress; inflammation; diabetic kidney disease

Issue: 2019, Volume 70, Issue 4
Pages: 1396-1398
Publication date: 2019/5/15
https://doi.org/10.37358/RC.19.4.7135
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TOTAN, A., BALCANGIU-STROESCU, A., IMRE, M.M., MIRICESCU, D., BALAN, D., STANESCU, I., IONESCU, D., TIMOFTE, D., TANASESCU, M.D., GREABU, M., XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease, Rev. Chim., 70(4), 2019, 1396-1398.

Vancouver
Totan A, Balcangiu-Stroescu A, Imre MM, Miricescu D, Balan D, Stanescu I, Ionescu D, Timofte D, Tanasescu MD, Greabu M. XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease. Rev. Chim.[internet]. 2019 Apr;70(4):1396-1398. Available from: https://doi.org/10.37358/RC.19.4.7135


APA 6th edition
Totan, A., Balcangiu-Stroescu, A., Imre, M.M., Miricescu, D., Balan, D., Stanescu, I.,... Greabu, M. (2019). XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease. Revista de Chimie, 70(4), 1396-1398. https://doi.org/10.37358/RC.19.4.7135


Harvard
Totan, A., Balcangiu-Stroescu, A., Imre, M.M., Miricescu, D., Balan, D., Stanescu, I., Ionescu, D., Timofte, D., Tanasescu, M.D., Greabu, M. (2019). 'XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease', Revista de Chimie, 70(4), pp. 1396-1398. https://doi.org/10.37358/RC.19.4.7135


IEEE
A. Totan, A. Balcangiu-Stroescu, M.M. Imre, D. Miricescu, D. Balan, I. Stanescu, D. Ionescu, D. Timofte, M.D. Tanasescu, M. Greabu, "XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease". Revista de Chimie, vol. 70, no. 4, pp. 1396-1398, 2019. [online]. https://doi.org/10.37358/RC.19.4.7135


Text
Alexandra Totan, Andra-Elena Balcangiu-Stroescu, Marina Melescanu Imre, Daniela Miricescu, Daniela Balan, Iulia-Ioana Stanescu, Dorin Ionescu, Delia Timofte, Maria Daniela Tanasescu, Maria Greabu,
XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1396-1398,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7135.
(https://revistadechimie.ro/Articles.asp?ID=7135)
Keywords: xanthine oxidoreductase; oxidative stress; inflammation; diabetic kidney disease


RIS
TY - JOUR
T1 - XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease
A1 - Totan, Alexandra
A2 - Balcangiu-Stroescu, Andra-Elena
A3 - Imre, Marina Melescanu
A4 - Miricescu, Daniela
A5 - Balan, Daniela
A6 - Stanescu, Iulia-Ioana
A7 - Ionescu, Dorin
A8 - Timofte, Delia
A9 - Tanasescu, Maria Daniela
A10 - Greabu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1396
EP - 1398
UR - https://doi.org/10.37358/RC.19.4.7135
KW - xanthine oxidoreductase
KW - oxidative stress
KW - inflammation
KW - diabetic kidney disease
ER -


BibTex
@article{RevCh2019P1396,
author = {Totan Alexandra and Balcangiu-Stroescu Andra-Elena and Imre Marina Melescanu and Miricescu Daniela and Balan Daniela and Stanescu Iulia-Ioana and Ionescu Dorin and Timofte Delia and Tanasescu Maria Daniela and Greabu Maria},
title = {XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1396-1398},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7135},
url = {https://revistadechimie.ro/Articles.asp?ID=7135}
}
 
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