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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 5, 1582-1585

https://doi.org/10.37358/RC.19.5.7173

Ionela Silivastru (Cozlea), Gabriela Keresztesi, Arthur Atilla Keresztesi, Daniel Laurentiu Cozlea, Carmen Caldararu, Daniela Ecaterina Dobru

Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy

Abstract:

The risk of bleeding in atrial fibrillation patients on direct oral anticoagulant treatment increases with age; particularly dabigatran is associated with a higher risk of gastrointestinal bleeding in elderly patients, low body mass ([48 kg) and women due to the induced dyspepsia. We aimed to evaluate the safety of direct oral anticoagulants (DOAC) dabigatran, rivaroxaban and apixaban by comparing each agent with a widely used vitamin K antagonist (VKA)-acenocoumarol in terms of bleeding event rates. A retrospective study regarding bleeding events in atrial fibrillation patients treated with oral anticoagulation (OAC) was performed. Haematuria, epistaxis and haemoptysis were considered minor events and intracranial bleeding, gastrointestinal bleeding (superior or inferior), blood transfusion after haemorrhagic events linked to OAC treatment were considered to be major events. A number of 219 atrial fibrillation patients were included using electronic medical records: 118 patients treated with DOAC s (82 using dabigatran, 28 on rivaroxaban regimen and 8 cases treated with apixaban) and 101 cases had vitamin K antagonists treatment (acenocumarol). A total of 75 bleeding events were encountered (70 minor and 5 major). A higher number of events were encountered in patients treated with DOAC s, but with no statistically significant difference compared to acenocumarol. The associated risk factors did not play a decisive role in bleeding events in the two treatment groups. No statistical significant difference was noted between the occurrence of haemorrhagic events and the class of oral anticoagulant treatment used (DOAC vs. VKA).
Keywords:
atrial fibrillation; bleeding events; direct oral anticoagulants; vitamin K antagonist

Issue: 2019, Volume 70, Issue 5
Pages: 1582-1585
Publication date: 2019/6/15
https://doi.org/10.37358/RC.19.5.7173
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SILIVASTRU (COZLEA), I., KERESZTESI, G., KERESZTESI, A.A., COZLEA, D.L., CALDARARU, C., DOBRU, D.E., Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy, Rev. Chim., 70(5), 2019, 1582-1585.

Vancouver
Silivastru (Cozlea) I, Keresztesi G, Keresztesi AA, Cozlea DL, Caldararu C, Dobru DE. Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy. Rev. Chim.[internet]. 2019 May;70(5):1582-1585. Available from: https://doi.org/10.37358/RC.19.5.7173


APA 6th edition
Silivastru (Cozlea), I., Keresztesi, G., Keresztesi, A.A., Cozlea, D.L., Caldararu, C. & Dobru, D.E. (2019). Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy. Revista de Chimie, 70(5), 1582-1585. https://doi.org/10.37358/RC.19.5.7173


Harvard
Silivastru (Cozlea), I., Keresztesi, G., Keresztesi, A.A., Cozlea, D.L., Caldararu, C., Dobru, D.E. (2019). 'Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy', Revista de Chimie, 70(5), pp. 1582-1585. https://doi.org/10.37358/RC.19.5.7173


IEEE
I. Silivastru(Cozlea), G. Keresztesi, A.A. Keresztesi, D.L. Cozlea, C. Caldararu, D.E. Dobru, "Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy". Revista de Chimie, vol. 70, no. 5, pp. 1582-1585, 2019. [online]. https://doi.org/10.37358/RC.19.5.7173


Text
Ionela Silivastru(Cozlea), Gabriela Keresztesi, Arthur Atilla Keresztesi, Daniel Laurentiu Cozlea, Carmen Caldararu, Daniela Ecaterina Dobru,
Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy,
Revista de Chimie,
Volume 70, Issue 5,
2019,
Pages 1582-1585,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.5.7173.
(https://revistadechimie.ro/Articles.asp?ID=7173)
Keywords: atrial fibrillation; bleeding events; direct oral anticoagulants; vitamin K antagonist


RIS
TY - JOUR
T1 - Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy
A1 - Silivastru (Cozlea), Ionela
A2 - Keresztesi, Gabriela
A3 - Keresztesi, Arthur Atilla
A4 - Cozlea, Daniel Laurentiu
A5 - Caldararu, Carmen
A6 - Dobru, Daniela Ecaterina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 5
SP - 1582
EP - 1585
UR - https://doi.org/10.37358/RC.19.5.7173
KW - atrial fibrillation
KW - bleeding events
KW - direct oral anticoagulants
KW - vitamin K antagonist
ER -


BibTex
@article{RevCh2019P1582,
author = {Silivastru (Cozlea) Ionela and Keresztesi Gabriela and Keresztesi Arthur Atilla and Cozlea Daniel Laurentiu and Caldararu Carmen and Dobru Daniela Ecaterina},
title = {Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy},
journal = {Revista de Chimie},
volume = {70},
number = {5},
pages = {1582-1585},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.5.7173},
url = {https://revistadechimie.ro/Articles.asp?ID=7173}
}
 
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