Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas

Suceveanu, Andra Iulia; Mazilu, Laura; Nitipir, Cornelia; Stoian, Anca Pantea; Parepa, Irinel; Voinea, Claudia; Suceveanu, Adrian Paul

Andra Iulia Suceveanu, Laura Mazilu, Cornelia Nitipir, Anca Pantea Stoian, Irinel Parepa, Claudia Voinea, Adrian Paul Suceveanu

Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas

Abstract:

Interval colorectal cancer (ICRC) means CRC discovered at or before the second colonoscopy during a screening interval. Literature provides data concerning the present issue, 7.2-9% of CRCs meeting the definition of interval CRC, without knowing the risk factors for this. We aimed to study if diabetes mellitus (DM) patients have a greater risk to develop ICRC/advanced adenomas (ACRA). We randomly included in the study 50 patients aged over 50 years old diagnosed with DM in whom colonoscopy was done for different reasons. Were excluded patients with CRC/ACRA diagnosed at first colonoscopy and results were compared to those of an age/gender-matched group of patients without DM as background. The interval of colonoscopies was fixed at 36 months (the shortest interval used for surveillance after a polypectomy). The total number of interval lesions significantly differs in our two groups (p=0.022, q=0.17). Interval CRC, serrated adenomas and villous adenomas were more frequent in the T2D group. (p = 0.013, p= 0.032, respectively p=0.011, q=0.14). DALM lesions were more frequently present in controls than in T2D (p=0.049) Results showed that patients with interval ICRC were two times more in DM group in male gender (p=0.003, ss) (4 pts, respectively 2 pts) and 1.5 times greater in female group (3 pts, respectively 2 pts). The rate of CRC occurrence during the interval period of 36 months was 0.16% for male and 0.12% for females. Regarding the occurrence of ACRA (villous/tubulovillous adenomas), male patients with DM had 3 times more ACRA lesions than the control group (p=0.029, ss) (9 pts vs 3 pts) while females patients with DM had 2 times more ACRA than controls (p=0.031, ss) (6 pts vs 3 pts). The rate of interval advanced CR lesions occurrence during the interval period of 36 months was 0.36% for male and 0.24% for females. DM looks be a risk factor ICRC/ACRA by accelerating the colorectal epithelial proliferation rate. Male gender looks to be more exposed to ICRC/ACRC, especially when they are diagnosed with metabolic co-morbidities like T2D.

Keywords:
interval; colorectal cancer; diabetes mellitus

Issue: 2019, Volume 70, Issue 5

Pages: 1808-1811

Publication date: 2019/6/15

https://doi.org/10.37358/RC.19.5.7220

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SUCEVEANU, A.I., MAZILU, L., NITIPIR, C., STOIAN, A.P., PAREPA, I., VOINEA, C., SUCEVEANU, A.P., Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas, Rev. Chim., 70(5), 2019, 1808-1811.

Vancouver
Suceveanu AI, Mazilu L, Nitipir C, Stoian AP, Parepa I, Voinea C, Suceveanu AP. Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas. Rev. Chim.[internet]. 2019 May;70(5):1808-1811. Available from: https://doi.org/10.37358/RC.19.5.7220

APA 6th edition
Suceveanu, A.I., Mazilu, L., Nitipir, C., Stoian, A.P., Parepa, I., Voinea, C. & Suceveanu, A.P. (2019). Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas. Revista de Chimie, 70(5), 1808-1811. https://doi.org/10.37358/RC.19.5.7220

Harvard
Suceveanu, A.I., Mazilu, L., Nitipir, C., Stoian, A.P., Parepa, I., Voinea, C., Suceveanu, A.P. (2019). 'Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas', Revista de Chimie, 70(5), pp. 1808-1811. https://doi.org/10.37358/RC.19.5.7220

IEEE
A.I. Suceveanu, L. Mazilu, C. Nitipir, A.P. Stoian, I. Parepa, C. Voinea, A.P. Suceveanu, "Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas". Revista de Chimie, vol. 70, no. 5, pp. 1808-1811, 2019. [online]. https://doi.org/10.37358/RC.19.5.7220

Text
Andra Iulia Suceveanu, Laura Mazilu, Cornelia Nitipir, Anca Pantea Stoian, Irinel Parepa, Claudia Voinea, Adrian Paul Suceveanu,
Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas,
Revista de Chimie,
Volume 70, Issue 5,
2019,
Pages 1808-1811,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.5.7220.
(https://revistadechimie.ro/Articles.asp?ID=7220)
Keywords: interval; colorectal cancer; diabetes mellitus

RIS
TY - JOUR
T1 - Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas
A1 - Suceveanu, Andra Iulia
A2 - Mazilu, Laura
A3 - Nitipir, Cornelia
A4 - Stoian, Anca Pantea
A5 - Parepa, Irinel
A6 - Voinea, Claudia
A7 - Suceveanu, Adrian Paul
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 5
SP - 1808
EP - 1811
UR - https://doi.org/10.37358/RC.19.5.7220
KW - interval
KW - colorectal cancer
KW - diabetes mellitus
ER -

BibTex
@article{RevCh2019P1808,
author = {Suceveanu Andra Iulia and Mazilu Laura and Nitipir Cornelia and Stoian Anca Pantea and Parepa Irinel and Voinea Claudia and Suceveanu Adrian Paul},
title = {Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas},
journal = {Revista de Chimie},
volume = {70},
number = {5},
pages = {1808-1811},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.5.7220},
url = {https://revistadechimie.ro/Articles.asp?ID=7220}
}

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