Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies

Stan, Roxana Liana; Sevastre, Bogdan; Hangan, Adriana Corina; Bota, Sanda; Hanganu, Daniela; Ionescu, Corina Maria Lucia; Popovici, Cristian; Sevastre-Berghian, Alexandra Cristina; Dreanca, Alexandra; Vicas, Laura Gratiela

Roxana Liana Stan, Bogdan Sevastre, Adriana Corina Hangan, Sanda Bota, Daniela Hanganu, Corina Maria Lucia Ionescu, Cristian Popovici, Alexandra Cristina Sevastre-Berghian, Alexandra Dreanca, Laura Gratiela Vicas

Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies

Abstract:

The purpose of the study was to demonstrate in vitro antioxidant activity and in vivo toxicity of the Artemisia Annua L. extract. The plant was harvested from Bihor area (Crisul Repede and Negru river valleys), Romania. Preparation of the plant product and of the lyophilizated extract was carried out in accordance with the Romanian Pharmacopeia Xth Edition. Lyophilized extract was evaluated in terms of polyphenol content using HPLC method. Antioxidant activity was highlighted using the DPPH, ABTS and FRAP methods. Hepatic, renal and haematological toxicity studies have been performed on laboratory mice. For this purpose blood and organs were collected. Biochemical and haematological parameters were determined on the blood samples and histopathological examination was performed on organs. In vitro antioxidant effect of Artemisia Annua L extract and its lack of in vivo toxicity were demonstrated. It is desirable to obtain a new phytoproduct harvested from spontaneous flora of Romania with antioxidant / antitumoral properties and which is devoid of toxicity.

Keywords:
extract; antioxidant; toxicity; phytoproduct

Issue: 2019, Volume 70, Issue 6

Pages: 1903-1907

Publication date: 2019/7/15

https://doi.org/10.37358/RC.19.6.7243

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STAN, R.L., SEVASTRE, B., HANGAN, A.C., BOTA, S., HANGANU, D., IONESCU, C.M.L., POPOVICI, C., SEVASTRE-BERGHIAN, A.C., DREANCA, A., VICAS, L.G., Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies, Rev. Chim., 70(6), 2019, 1903-1907.

Vancouver
Stan RL, Sevastre B, Hangan AC, Bota S, Hanganu D, Ionescu CML, Popovici C, Sevastre-Berghian AC, Dreanca A, Vicas LG. Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies. Rev. Chim.[internet]. 2019 Jun;70(6):1903-1907. Available from: https://doi.org/10.37358/RC.19.6.7243

APA 6th edition
Stan, R.L., Sevastre, B., Hangan, A.C., Bota, S., Hanganu, D., Ionescu, C.M.L.,... Vicas, L.G. (2019). Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies. Revista de Chimie, 70(6), 1903-1907. https://doi.org/10.37358/RC.19.6.7243

Harvard
Stan, R.L., Sevastre, B., Hangan, A.C., Bota, S., Hanganu, D., Ionescu, C.M.L., Popovici, C., Sevastre-Berghian, A.C., Dreanca, A., Vicas, L.G. (2019). 'Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies', Revista de Chimie, 70(6), pp. 1903-1907. https://doi.org/10.37358/RC.19.6.7243

IEEE
R.L. Stan, B. Sevastre, A.C. Hangan, S. Bota, D. Hanganu, C.M.L. Ionescu, C. Popovici, A.C. Sevastre-Berghian, A. Dreanca, L.G. Vicas, "Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies". Revista de Chimie, vol. 70, no. 6, pp. 1903-1907, 2019. [online]. https://doi.org/10.37358/RC.19.6.7243

Text
Roxana Liana Stan, Bogdan Sevastre, Adriana Corina Hangan, Sanda Bota, Daniela Hanganu, Corina Maria Lucia Ionescu, Cristian Popovici, Alexandra Cristina Sevastre-Berghian, Alexandra Dreanca, Laura Gratiela Vicas,
Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies,
Revista de Chimie,
Volume 70, Issue 6,
2019,
Pages 1903-1907,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.6.7243.
(https://revistadechimie.ro/Articles.asp?ID=7243)
Keywords: extract; antioxidant; toxicity; phytoproduct

RIS
TY - JOUR
T1 - Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies
A1 - Stan, Roxana Liana
A2 - Sevastre, Bogdan
A3 - Hangan, Adriana Corina
A4 - Bota, Sanda
A5 - Hanganu, Daniela
A6 - Ionescu, Corina Maria Lucia
A7 - Popovici, Cristian
A8 - Sevastre-Berghian, Alexandra Cristina
A9 - Dreanca, Alexandra
A10 - Vicas, Laura Gratiela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 6
SP - 1903
EP - 1907
UR - https://doi.org/10.37358/RC.19.6.7243
KW - extract
KW - antioxidant
KW - toxicity
KW - phytoproduct
ER -

BibTex
@article{RevCh2019P1903,
author = {Stan Roxana Liana and Sevastre Bogdan and Hangan Adriana Corina and Bota Sanda and Hanganu Daniela and Ionescu Corina Maria Lucia and Popovici Cristian and Sevastre-Berghian Alexandra Cristina and Dreanca Alexandra and Vicas Laura Gratiela},
title = {Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies},
journal = {Revista de Chimie},
volume = {70},
number = {6},
pages = {1903-1907},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.6.7243},
url = {https://revistadechimie.ro/Articles.asp?ID=7243}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)

News, Events

Gold Open Access | Source=http://www.plos.org/ | Author=art designer at PLoS

Conferences of Contemporary
Chemistry

Biblioteca Chimiei

Materiale Plastice

REVISTA DE CHIMIE

About

Board

Indexing