Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia

Moisa, Cornel; Gaman, Mihnea Alexandru; Diaconu, Camelia Cristina; Gaman, Amelia Maria

Cornel Moisa, Mihnea Alexandru Gaman, Camelia Cristina Diaconu, Amelia Maria Gaman

Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia

Abstract:

Essential thrombocythemia (ET) is a BCR-ABL1-negative myeloproliferative neoplasm associated with thrombotic and haemorrhagic complications. Reactive oxygen species (ROS) overexpression induces a growth advantage to JAK2V617F-positive clones and, in association with a higher number of immature platelets, leukocytosis, and additional cardiovascular risk factors, leads to an increased risk for thrombotic events. We evaluated oxidative stress by measuring ROS levels and the total antioxidant capacity (TAC) in 62 ET patients and investigated the relationship between oxidative stress, JAK2V617F mutational status and the development of thrombotic events. We found higher oxidative stress levels in JAK2V617F-positive vs. JAK2V617F-negative ET cases with no significant differences between homozygous and heterozygous genotypes. Increased ROS levels and thrombotic events were more frequent in ET patients with old age at diagnosis, higher haematocrit levels or leukocytosis.

Keywords:
essential thrombocythemia; reactive oxygen species; total antioxidant capacity; JAK2V617F; thrombosis

Issue: 2019, Volume 70, Issue 8

Pages: 2822-2825

Publication date: 2019/9/15

https://doi.org/10.37358/RC.19.8.7435

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MOISA, C., GAMAN, M.A., DIACONU, C.C., GAMAN, A.M., Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia, Rev. Chim., 70(8), 2019, 2822-2825.

Vancouver
Moisa C, Gaman MA, Diaconu CC, Gaman AM. Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia. Rev. Chim.[internet]. 2019 Aug;70(8):2822-2825. Available from: https://doi.org/10.37358/RC.19.8.7435

APA 6th edition
Moisa, C., Gaman, M.A., Diaconu, C.C. & Gaman, A.M. (2019). Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia. Revista de Chimie, 70(8), 2822-2825. https://doi.org/10.37358/RC.19.8.7435

Harvard
Moisa, C., Gaman, M.A., Diaconu, C.C., Gaman, A.M. (2019). 'Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia', Revista de Chimie, 70(8), pp. 2822-2825. https://doi.org/10.37358/RC.19.8.7435

IEEE
C. Moisa, M.A. Gaman, C.C. Diaconu, A.M. Gaman, "Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia". Revista de Chimie, vol. 70, no. 8, pp. 2822-2825, 2019. [online]. https://doi.org/10.37358/RC.19.8.7435

Text
Cornel Moisa, Mihnea Alexandru Gaman, Camelia Cristina Diaconu, Amelia Maria Gaman,
Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2822-2825,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7435.
(https://revistadechimie.ro/Articles.asp?ID=7435)
Keywords: essential thrombocythemia; reactive oxygen species; total antioxidant capacity; JAK2V617F; thrombosis

RIS
TY - JOUR
T1 - Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia
A1 - Moisa, Cornel
A2 - Gaman, Mihnea Alexandru
A3 - Diaconu, Camelia Cristina
A4 - Gaman, Amelia Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2822
EP - 2825
UR - https://doi.org/10.37358/RC.19.8.7435
KW - essential thrombocythemia
KW - reactive oxygen species
KW - total antioxidant capacity
KW - JAK2V617F
KW - thrombosis
ER -

BibTex
@article{RevCh2019P2822,
author = {Moisa Cornel and Gaman Mihnea Alexandru and Diaconu Camelia Cristina and Gaman Amelia Maria},
title = {Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2822-2825},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7435},
url = {https://revistadechimie.ro/Articles.asp?ID=7435}
}

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