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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 2866-2868

https://doi.org/10.37358/RC.19.8.7445

Paula Petric, Lorena Dima, Petru Ifteni, Andreea Teodorescu, Claudia Gavris, Alina Mihaela Pascu, Vladimir Poroch, Victoria Burtea

Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment

Abstract:

Approximately 30% of patients are included in treatment-resistant schizophrenia and clozapine remains the only antipsychotic with proved superior efficacy in these cases. Currently, although clozapine is considered as the most effective pharmacological intervention for treatment-resistant schizophrenia in all national guidelines, its use is suboptimal due to doctors’ concerns about tolerability and inappropriate adherence of patients to haematological monitoring required for early detection of severe neutropenia. Although treatment guidelines recommend the use of clozapine starting with a dose of 12.5-25 mg/day and gradual increase over a 2-week period until the therapeutic dose is reached, this recommendation was not derived from rigorous controlled studies. Slow or standard titration of clozapine increases the need for additional psychotropics and risks associated with antipsychotic polypharmacy, and can unnecessarily prolong the patient’s suffering and the length of hospitalization. A relationship between a faster titration and a higher incidence of clozapine-induced dangerous adverse effects has not been clearly demonstrated by clinical trials. Therapeutic drug monitoring is of great importance for drugs with a high inter-individual variability in serum concentration, a narrow therapeutic range or serious toxic side effects.
Keywords:
clozapine; norclozapine; titration; drug monitoring; serum level

Issue: 2019, Volume 70, Issue 8
Pages: 2866-2868
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7445
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PETRIC, P., DIMA, L., IFTENI, P., TEODORESCU, A., GAVRIS, C., PASCU, A.M., POROCH, V., BURTEA, V., Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment, Rev. Chim., 70(8), 2019, 2866-2868.

Vancouver
Petric P, Dima L, Ifteni P, Teodorescu A, Gavris C, Pascu AM, Poroch V, Burtea V. Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment. Rev. Chim.[internet]. 2019 Aug;70(8):2866-2868. Available from: https://doi.org/10.37358/RC.19.8.7445


APA 6th edition
Petric, P., Dima, L., Ifteni, P., Teodorescu, A., Gavris, C., Pascu, A.M., Poroch, V. & Burtea, V. (2019). Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment. Revista de Chimie, 70(8), 2866-2868. https://doi.org/10.37358/RC.19.8.7445


Harvard
Petric, P., Dima, L., Ifteni, P., Teodorescu, A., Gavris, C., Pascu, A.M., Poroch, V., Burtea, V. (2019). 'Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment', Revista de Chimie, 70(8), pp. 2866-2868. https://doi.org/10.37358/RC.19.8.7445


IEEE
P. Petric, L. Dima, P. Ifteni, A. Teodorescu, C. Gavris, A.M. Pascu, V. Poroch, V. Burtea, "Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment". Revista de Chimie, vol. 70, no. 8, pp. 2866-2868, 2019. [online]. https://doi.org/10.37358/RC.19.8.7445


Text
Paula Petric, Lorena Dima, Petru Ifteni, Andreea Teodorescu, Claudia Gavris, Alina Mihaela Pascu, Vladimir Poroch, Victoria Burtea,
Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2866-2868,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7445.
(https://revistadechimie.ro/Articles.asp?ID=7445)
Keywords: clozapine; norclozapine; titration; drug monitoring; serum level


RIS
TY - JOUR
T1 - Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment
A1 - Petric, Paula
A2 - Dima, Lorena
A3 - Ifteni, Petru
A4 - Teodorescu, Andreea
A5 - Gavris, Claudia
A6 - Pascu, Alina Mihaela
A7 - Poroch, Vladimir
A8 - Burtea, Victoria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2866
EP - 2868
UR - https://doi.org/10.37358/RC.19.8.7445
KW - clozapine
KW - norclozapine
KW - titration
KW - drug monitoring
KW - serum level
ER -


BibTex
@article{RevCh2019P2866,
author = {Petric Paula and Dima Lorena and Ifteni Petru and Teodorescu Andreea and Gavris Claudia and Pascu Alina Mihaela and Poroch Vladimir and Burtea Victoria},
title = {Clozapine Efficacy, Type of Titration and Therapeutic Drug Monitoring Using Chemical Methods for Serum Level Assessment},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2866-2868},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7445},
url = {https://revistadechimie.ro/Articles.asp?ID=7445}
}
 
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