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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 3008-3013

https://doi.org/10.37358/RC.19.8.7475

Silvia Maria Stoicescu, Ramona Mohora, Monica Luminos, Madalina Maria Merisescu, Gheorghita Jugulete, Leonard Nastase

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

Abstract:

Difficulties in establishing the onset of neonatal sepsis has directed the medical research in recent years to the possibility of identifying early biological markers of diagnosis. Overdiagnosing neonatal sepsis leads to a higher rate and duration in the usage of antibiotics in the Neonatal Intensive Care Unit (NICU), which in term leads to a rise in bacterial resistance, antibiotherapy complications, duration of hospitalization and costs.Concomitant analysis of CRP (C Reactive Protein), procalcitonin, complete blood count, presepsin in newborn babies with suspicion of early or late neonatal sepsis. Presepsin sensibility and specificity in diagnosing neonatal sepsis. The study group consists of newborns admitted to Polizu Neonatology Clinic between 15th February- 15th July 2017, with suspected neonatal sepsis. We analyzed: clinical manifestations and biochemical markers values used for diagnosis of sepsis, namely the value of CRP, presepsin and procalcitonin on the onset day of the disease and later, according to evolution. CRP values may be influenced by clinical pathology. Procalcitonin values were mainly influenced by the presence of jaundice. Presepsin is the biochemical marker with the fastest predictive values of positive infection. Presepsin can be a useful tool for early diagnosis of neonatal sepsis and can guide the antibiotic treatment. Presepsin value is significantly higher in neonatal sepsis compared to healthy newborns (939 vs 368 ng/mL, p [ 0.0001); area under receiver operating curve (AUC) for presepsine was 0.931 (95% confidence interval 0.86-1.0). PSP has a greater sensibility and specificity compared to classical sepsis markers, CRP and PCT respectively (AUC 0.931 vs 0.857 vs 0.819, p [ 0.001). The cut off value for presepsin was established at 538 ng/mLwith a sensibility of 79.5% and a specificity of 87.2 %. The positive predictive value (PPV) is 83.8 % and negative predictive value (NPV) is 83.3%.
Keywords:
presepsin; sepsis marker; NICU

Issue: 2019, Volume 70, Issue 8
Pages: 3008-3013
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7475
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
STOICESCU, S.M., MOHORA, R., LUMINOS, M., MERISESCU, M.M., JUGULETE, G., NASTASE, L., Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience, Rev. Chim., 70(8), 2019, 3008-3013.

Vancouver
Stoicescu SM, Mohora R, Luminos M, Merisescu MM, Jugulete G, Nastase L. Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience. Rev. Chim.[internet]. 2019 Aug;70(8):3008-3013. Available from: https://doi.org/10.37358/RC.19.8.7475


APA 6th edition
Stoicescu, S.M., Mohora, R., Luminos, M., Merisescu, M.M., Jugulete, G. & Nastase, L. (2019). Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience. Revista de Chimie, 70(8), 3008-3013. https://doi.org/10.37358/RC.19.8.7475


Harvard
Stoicescu, S.M., Mohora, R., Luminos, M., Merisescu, M.M., Jugulete, G., Nastase, L. (2019). 'Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience', Revista de Chimie, 70(8), pp. 3008-3013. https://doi.org/10.37358/RC.19.8.7475


IEEE
S.M. Stoicescu, R. Mohora, M. Luminos, M.M. Merisescu, G. Jugulete, L. Nastase, "Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience". Revista de Chimie, vol. 70, no. 8, pp. 3008-3013, 2019. [online]. https://doi.org/10.37358/RC.19.8.7475


Text
Silvia Maria Stoicescu, Ramona Mohora, Monica Luminos, Madalina Maria Merisescu, Gheorghita Jugulete, Leonard Nastase,
Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 3008-3013,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7475.
(https://revistadechimie.ro/Articles.asp?ID=7475)
Keywords: presepsin; sepsis marker; NICU


RIS
TY - JOUR
T1 - Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience
A1 - Stoicescu, Silvia Maria
A2 - Mohora, Ramona
A3 - Luminos, Monica
A4 - Merisescu, Madalina Maria
A5 - Jugulete, Gheorghita
A6 - Nastase, Leonard
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 3008
EP - 3013
UR - https://doi.org/10.37358/RC.19.8.7475
KW - presepsin
KW - sepsis marker
KW - NICU
ER -


BibTex
@article{RevCh2019P3008,
author = {Stoicescu Silvia Maria and Mohora Ramona and Luminos Monica and Merisescu Madalina Maria and Jugulete Gheorghita and Nastase Leonard},
title = {Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {3008-3013},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7475},
url = {https://revistadechimie.ro/Articles.asp?ID=7475}
}
 
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