ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 10, 3741-3745

https://doi.org/10.37358/RC.19.10.7637

Liliana Baroiu, Adrian Beznea, Catalin Plesea Condratovici, Cristian Onisor, Camelia Ana Grigore, Gabi Topor, Sorin Rugina

Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection

Abstract:

The infection with Clostridium difficile (CDI), which appeared at epidemic level, after acquiring the germ of some fluoroquinolone resistance genes, initially considered nosocomial infection and adverse effect post-antibiotic therapy, is affecting more and more people without risk factors and extending into the community. This paper proposes an analysis of the two main antibiotics used in therapy: metronidazole and vancomycin, the evidence of efficacy in the literature and the chemical stability of antibiotics in simulated gastrointestinal fluid. Based on UV-Vis absorption spectra, it can be considered that there are no major changes in the chemical structure of the investigated drugs in the presence of gastro-duodenal conditions. Clinical impact of comparative treatment with metronidazole and vancomycin has also been studied, in a group of 720 CDI patients hospitalized during the period 1.01.2017-31.12.2018 in the Clinical Hospital St. Parascheva of Infectious Diseases Galati. From this group, two subgroups were selected, one of 284 patients receiving oral vancomycin treatment and one group of 62 patients receiving oral metronidazole for an initial nonsevere episode of CDI. The number of days from the beginning of the treatment until the normalization of the stool, the length of hospitalization, the number of days of antibiotic treatment and the percentage of relapses were comparable in the two groups, the percentage of deaths in the first 30 days from the episode of CDI was higher in the vancomycin-treated group, probably due mainly to the severe comorbidities of these patients. The conclusion of the study is that the treatments with metronidazole and vancomycin, of the initial episode, nonsevere of CDI are comparable as a therapeutic response, provided that the patients treated with metronidazole do not associate hepatic, renal or neurological impairment due to the risk of adverse reactions.
Keywords:
Clostridium difficile; metronidazole; vancomycine; chemical stability; UV-Vis spectra

Issue: 2019, Volume 70, Issue 10
Pages: 3741-3745
Publication date: 2019/11/15
https://doi.org/10.37358/RC.19.10.7637
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BAROIU, L., BEZNEA, A., CONDRATOVICI, C.P., ONISOR, C., GRIGORE, C.A., TOPOR, G., RUGINA, S., Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection, Rev. Chim., 70(10), 2019, 3741-3745.

Vancouver
Baroiu L, Beznea A, Condratovici CP, Onisor C, Grigore CA, Topor G, Rugina S. Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection. Rev. Chim.[internet]. 2019 Oct;70(10):3741-3745. Available from: https://doi.org/10.37358/RC.19.10.7637


APA 6th edition
Baroiu, L., Beznea, A., Condratovici, C.P., Onisor, C., Grigore, C.A., Topor, G. & Rugina, S. (2019). Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection. Revista de Chimie, 70(10), 3741-3745. https://doi.org/10.37358/RC.19.10.7637


Harvard
Baroiu, L., Beznea, A., Condratovici, C.P., Onisor, C., Grigore, C.A., Topor, G., Rugina, S. (2019). 'Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection', Revista de Chimie, 70(10), pp. 3741-3745. https://doi.org/10.37358/RC.19.10.7637


IEEE
L. Baroiu, A. Beznea, C.P. Condratovici, C. Onisor, C.A. Grigore, G. Topor, S. Rugina, "Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection". Revista de Chimie, vol. 70, no. 10, pp. 3741-3745, 2019. [online]. https://doi.org/10.37358/RC.19.10.7637


Text
Liliana Baroiu, Adrian Beznea, Catalin Plesea Condratovici, Cristian Onisor, Camelia Ana Grigore, Gabi Topor, Sorin Rugina,
Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3741-3745,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7637.
(https://revistadechimie.ro/Articles.asp?ID=7637)
Keywords: Clostridium difficile; metronidazole; vancomycine; chemical stability; UV-Vis spectra


RIS
TY - JOUR
T1 - Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection
A1 - Baroiu, Liliana
A2 - Beznea, Adrian
A3 - Condratovici, Catalin Plesea
A4 - Onisor, Cristian
A5 - Grigore, Camelia Ana
A6 - Topor, Gabi
A7 - Rugina, Sorin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3741
EP - 3745
UR - https://doi.org/10.37358/RC.19.10.7637
KW - Clostridium difficile
KW - metronidazole
KW - vancomycine
KW - chemical stability
KW - UV-Vis spectra
ER -


BibTex
@article{RevCh2019P3741,
author = {Baroiu Liliana and Beznea Adrian and Condratovici Catalin Plesea and Onisor Cristian and Grigore Camelia Ana and Topor Gabi and Rugina Sorin},
title = {Comparative Effectiveness of Vancomycin and Metronidazole for the Initial Episode of Nonsevere Clostridium Difficle Infection},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3741-3745},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7637},
url = {https://revistadechimie.ro/Articles.asp?ID=7637}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice