Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes

Rosca, Elena Valentina; Apostol, Theodora Venera; Draghici, Constantin; Olaru, Octavian Tudorel; Socea, Laura Ileana; Iscrulescu, Lucian; Saramet, Gabriel; Barbuceanu, Florica; Pahontu, Elena Mihaela; Baraitareanu, Stelian; Barbuceanu, Stefania Felicia

Elena Valentina Rosca, Theodora Venera Apostol, Constantin Draghici, Octavian Tudorel Olaru, Laura Ileana Socea, Lucian Iscrulescu, Gabriel Saramet, Florica Barbuceanu, Elena Mihaela Pahontu, Stelian Baraitareanu, Stefania Felicia Barbuceanu

Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes

Abstract:

This paper presents the synthesis of new heterocyclic compounds from oxazoles and triazinones classes. Some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids were condensed with 4-iodobenzaldehyde in presence of acetic anhydride and sodium acetate, when the new corresponding unsaturated oxazol-5(4H)-one were obtained. Through the reaction of these oxazol-5(4H)-ones with phenylhydrazine, in presence of the acetic acid and sodium acetate, the new heterocyclic compounds from 1,2,4-triazin-6(5H)-ones class were obtained. The structures of synthesized compounds have been confirmed by spectral methods (FT-IR, 1H-NMR, 13C-NMR and MS) and elemental analysis. The cytotoxicity of the compounds was evaluated using the Daphnia magna and Artemia salina bioassays.

Keywords:
oxazol-5(4H)-one; 1;2;4-triazin-6(5H)-one; cytotoxicity; Daphnia magna; Artemia salina

Issue: 2019, Volume 70, Issue 11

Pages: 3769-3774

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7644

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ROSCA, E.V., APOSTOL, T.V., DRAGHICI, C., OLARU, O.T., SOCEA, L.I., ISCRULESCU, L., SARAMET, G., BARBUCEANU, F., PAHONTU, E.M., BARAITAREANU, S., BARBUCEANU, S.F., Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes, Rev. Chim., 70(11), 2019, 3769-3774.

Vancouver
Rosca EV, Apostol TV, Draghici C, Olaru OT, Socea LI, Iscrulescu L, Saramet G, Barbuceanu F, Pahontu EM, Baraitareanu S, Barbuceanu SF. Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes. Rev. Chim.[internet]. 2019 Nov;70(11):3769-3774. Available from: https://doi.org/10.37358/RC.70.19.11.7644

APA 6th edition
Rosca, E.V., Apostol, T.V., Draghici, C., Olaru, O.T., Socea, L.I., Iscrulescu, L.,... Barbuceanu, S.F. (2019). Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes. Revista de Chimie, 70(11), 3769-3774. https://doi.org/10.37358/RC.70.19.11.7644

Harvard
Rosca, E.V., Apostol, T.V., Draghici, C., Olaru, O.T., Socea, L.I., Iscrulescu, L., Saramet, G., Barbuceanu, F., Pahontu, E.M., Baraitareanu, S., Barbuceanu, S.F. (2019). 'Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes', Revista de Chimie, 70(11), pp. 3769-3774. https://doi.org/10.37358/RC.70.19.11.7644

IEEE
E.V. Rosca, T.V. Apostol, C. Draghici, O.T. Olaru, L.I. Socea, L. Iscrulescu, G. Saramet, F. Barbuceanu, E.M. Pahontu, S. Baraitareanu, S.F. Barbuceanu, "Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes". Revista de Chimie, vol. 70, no. 11, pp. 3769-3774, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7644

Text
Elena Valentina Rosca, Theodora Venera Apostol, Constantin Draghici, Octavian Tudorel Olaru, Laura Ileana Socea, Lucian Iscrulescu, Gabriel Saramet, Florica Barbuceanu, Elena Mihaela Pahontu, Stelian Baraitareanu, Stefania Felicia Barbuceanu,
Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3769-3774,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7644.
(https://revistadechimie.ro/Articles.asp?ID=7644)
Keywords: oxazol-5(4H)-one; 1;2;4-triazin-6(5H)-one; cytotoxicity; Daphnia magna; Artemia salina

RIS
TY - JOUR
T1 - Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes
A1 - Rosca, Elena Valentina
A2 - Apostol, Theodora Venera
A3 - Draghici, Constantin
A4 - Olaru, Octavian Tudorel
A5 - Socea, Laura Ileana
A6 - Iscrulescu, Lucian
A7 - Saramet, Gabriel
A8 - Barbuceanu, Florica
A9 - Pahontu, Elena Mihaela
A10 - Baraitareanu, Stelian
A11 - Barbuceanu, Stefania Felicia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3769
EP - 3774
UR - https://doi.org/10.37358/RC.70.19.11.7644
KW - oxazol-5(4H)-one
KW - 1
KW - 2
KW - 4-triazin-6(5H)-one
KW - cytotoxicity
KW - Daphnia magna
KW - Artemia salina
ER -

BibTex
@article{RevCh2019P3769,
author = {Rosca Elena Valentina and Apostol Theodora Venera and Draghici Constantin and Olaru Octavian Tudorel and Socea Laura Ileana and Iscrulescu Lucian and Saramet Gabriel and Barbuceanu Florica and Pahontu Elena Mihaela and Baraitareanu Stelian and Barbuceanu Stefania Felicia},
title = {Synthesis, characterization and Cytotoxicity Evaluation of New Compounds from Oxazol-5(4H)-Ones and 1,2,4-Triazin-6(5H)-Ones Classes},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3769-3774},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7644},
url = {https://revistadechimie.ro/Articles.asp?ID=7644}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)

News, Events

Gold Open Access | Source=http://www.plos.org/ | Author=art designer at PLoS

Conferences of Contemporary
Chemistry

Biblioteca Chimiei

Materiale Plastice

REVISTA DE CHIMIE

About

Board

Indexing