Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli  Strains

Hasegan, Adrian; Totan, Maria; Antonescu, Elisabeta; Bumbu, Adrian Gheorghe; Pantis, Carmen; Furau, Cristian; Bardaca (Urducea), Cristina; Grigore, Nicolae

Adrian Hasegan, Maria Totan, Elisabeta Antonescu, Adrian Gheorghe Bumbu, Carmen Pantis, Cristian Furau, Cristina Bardaca (Urducea), Nicolae Grigore

Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains

Abstract:

Urinary tract infections (UTIs) are the most common bacterial pathologies in children, but they are difficult to spot. The diagnosis relies on urine culture in order to measure the prevalence of the infection, to identify the etiology and the sensitivity of the germs to different antibiotics. Escherichia coli (E. coli) strains are the most common uro-pathogen germs. The change in sensitivity to antibiotic of these uro-pathogen bacteria should be closely monitored because the physicians should be informed about the evolution of the antibiotic resistance of E coli, for a more effective treatment in their fight against diseases. The study aimed to determine the prevalence of UTIs and the evolution of antimicrobial sensitivity for E. coli. This retrospective study was performed over a period of 4 years, 2013-2016, and included all the patients admitted in the Children‘s Hospital, aged 0-18 years, with the suspicion of UTIs; also, the standard culture techniques for urine samples, the modified Kirby-Bauer disk diffusion method for the antibiotic sensitivity testing, and the disk diffusion method to confirm the ESBL production by the clinical isolates of E. coli in urine were used. The statistical analysis was performed using the proportions of sensitive, resistant and intermediates. Descriptive statistics like the total, mean and percentage were performed using the Statistical Package for the Social Sciences (SPSS), version 15.0 and Microsoft Excel. From 15389 urine cultures processed in 4 years, 1530 were positive (9.9 %). Among these positive urine cultures, 1056 (69 %) were positive for E. coli. Testing the E. coli to a range of antibiotics, according to CLSI standard, a high resistance to Ampicillin (69-96%), Amoxicillin/Clavulanic acid (32-70%), Trimethoprim/Sulfamethoxazole (36-42%) was observed and low levels of resistance to Ceftazidime, Cefuroxime, Cefpodoxime, Gentamycin, Nalidixic acid. Among E. Coli strains, 9-9.6 % were ESBL positive. Despite the low number of positive urine cultures in a paediatric population, it is very important to perform the urine culture in order to correctly identify the etiology of UTIs, recommend the right antibiotic, and avoid the wrong use of the antibiotics in children.

Keywords:
E. coli antibiotic resistance; UTI; children

Issue: 2019, Volume 70, Issue 11

Pages: 3788-3792

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7648

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HASEGAN, A., TOTAN, M., ANTONESCU, E., BUMBU, A.G., PANTIS, C., FURAU, C., BARDACA (URDUCEA), C., GRIGORE, N., Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains, Rev. Chim., 70(11), 2019, 3788-3792.

Vancouver
Hasegan A, Totan M, Antonescu E, Bumbu AG, Pantis C, Furau C, Bardaca (Urducea) C, Grigore N. Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains. Rev. Chim.[internet]. 2019 Nov;70(11):3788-3792. Available from: https://doi.org/10.37358/RC.70.19.11.7648

APA 6th edition
Hasegan, A., Totan, M., Antonescu, E., Bumbu, A.G., Pantis, C., Furau, C., Bardaca (Urducea), C. & Grigore, N. (2019). Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains. Revista de Chimie, 70(11), 3788-3792. https://doi.org/10.37358/RC.70.19.11.7648

Harvard
Hasegan, A., Totan, M., Antonescu, E., Bumbu, A.G., Pantis, C., Furau, C., Bardaca (Urducea), C., Grigore, N. (2019). 'Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains', Revista de Chimie, 70(11), pp. 3788-3792. https://doi.org/10.37358/RC.70.19.11.7648

IEEE
A. Hasegan, M. Totan, E. Antonescu, A.G. Bumbu, C. Pantis, C. Furau, C. Bardaca(Urducea), N. Grigore, "Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains". Revista de Chimie, vol. 70, no. 11, pp. 3788-3792, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7648

Text
Adrian Hasegan, Maria Totan, Elisabeta Antonescu, Adrian Gheorghe Bumbu, Carmen Pantis, Cristian Furau, Cristina Bardaca(Urducea), Nicolae Grigore,
Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3788-3792,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7648.
(https://revistadechimie.ro/Articles.asp?ID=7648)
Keywords: E. coli antibiotic resistance; UTI; children

RIS
TY - JOUR
T1 - Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains
A1 - Hasegan, Adrian
A2 - Totan, Maria
A3 - Antonescu, Elisabeta
A4 - Bumbu, Adrian Gheorghe
A5 - Pantis, Carmen
A6 - Furau, Cristian
A7 - Bardaca (Urducea), Cristina
A8 - Grigore, Nicolae
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3788
EP - 3792
UR - https://doi.org/10.37358/RC.70.19.11.7648
KW - E. coli antibiotic resistance
KW - UTI
KW - children
ER -

BibTex
@article{RevCh2019P3788,
author = {Hasegan Adrian and Totan Maria and Antonescu Elisabeta and Bumbu Adrian Gheorghe and Pantis Carmen and Furau Cristian and Bardaca (Urducea) Cristina and Grigore Nicolae},
title = {Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3788-3792},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7648},
url = {https://revistadechimie.ro/Articles.asp?ID=7648}
}

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