Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing <br>4-(Phenylsulfonyl)phenyl Moiety

Apostol, Theodora Venera; Barbuceanu, Stefania Felicia; Socea, Laura Ileana; Draghici, Constantin; Saramet, Gabriel; Iscrulescu, Lucian; Olaru, Octavian Tudorel

Theodora Venera Apostol, Stefania Felicia Barbuceanu, Laura Ileana Socea, Constantin Draghici, Gabriel Saramet, Lucian Iscrulescu, Octavian Tudorel Olaru

Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety

Abstract:

The paper presents the synthesis, characterization and cytotoxicity assessment of five organic compounds containing 4-(phenylsulfonyl)phenyl fragment in the molecule, namely of three acyclic precursors derived from phenylalanine (from N-acyl-a-amino acids, N-acyl-a-amino acyl chlorides and N-acyl-a-amino ketones class) and of the cyclization products: a 1,3-oxazol-5(4H)-one and, respectively, a 1,3-oxazole substituted in position 5 with the p-tolyl group. The synthesized compounds were characterized by spectral methods (UV-Vis, FT-IR, 1H-NMR, 13C-NMR, and MS) and elemental analysis, which confirmed their structures. For the determination of the purity of the new compounds, the RP-HPLC method was used. In view of the therapeutic potential of the newly synthesized compounds, we evaluated their toxicological profile using the Daphnia magna bioassay.

Keywords:
N-acyl-a-amino acid; 1;3-oxazol-5(4H)-one; N-acyl-a-amino ketone; 1;3-oxazole; cytotoxic effect

Issue: 2019, Volume 70, Issue 11

Pages: 3793-3801

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7649

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
APOSTOL, T.V., BARBUCEANU, S.F., SOCEA, L.I., DRAGHICI, C., SARAMET, G., ISCRULESCU, L., OLARU, O.T., Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety, Rev. Chim., 70(11), 2019, 3793-3801.

Vancouver
Apostol TV, Barbuceanu SF, Socea LI, Draghici C, Saramet G, Iscrulescu L, Olaru OT. Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety. Rev. Chim.[internet]. 2019 Nov;70(11):3793-3801. Available from: https://doi.org/10.37358/RC.70.19.11.7649

APA 6th edition
Apostol, T.V., Barbuceanu, S.F., Socea, L.I., Draghici, C., Saramet, G., Iscrulescu, L. & Olaru, O.T. (2019). Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety. Revista de Chimie, 70(11), 3793-3801. https://doi.org/10.37358/RC.70.19.11.7649

Harvard
Apostol, T.V., Barbuceanu, S.F., Socea, L.I., Draghici, C., Saramet, G., Iscrulescu, L., Olaru, O.T. (2019). 'Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety', Revista de Chimie, 70(11), pp. 3793-3801. https://doi.org/10.37358/RC.70.19.11.7649

IEEE
T.V. Apostol, S.F. Barbuceanu, L.I. Socea, C. Draghici, G. Saramet, L. Iscrulescu, O.T. Olaru, "Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety". Revista de Chimie, vol. 70, no. 11, pp. 3793-3801, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7649

Text
Theodora Venera Apostol, Stefania Felicia Barbuceanu, Laura Ileana Socea, Constantin Draghici, Gabriel Saramet, Lucian Iscrulescu, Octavian Tudorel Olaru,
Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3793-3801,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7649.
(https://revistadechimie.ro/Articles.asp?ID=7649)
Keywords: N-acyl-a-amino acid; 1;3-oxazol-5(4H)-one; N-acyl-a-amino ketone; 1;3-oxazole; cytotoxic effect

RIS
TY - JOUR
T1 - Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety
A1 - Apostol, Theodora Venera
A2 - Barbuceanu, Stefania Felicia
A3 - Socea, Laura Ileana
A4 - Draghici, Constantin
A5 - Saramet, Gabriel
A6 - Iscrulescu, Lucian
A7 - Olaru, Octavian Tudorel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3793
EP - 3801
UR - https://doi.org/10.37358/RC.70.19.11.7649
KW - N-acyl-a-amino acid
KW - 1
KW - 3-oxazol-5(4H)-one
KW - N-acyl-a-amino ketone
KW - 1
KW - 3-oxazole
KW - cytotoxic effect
ER -

BibTex
@article{RevCh2019P3793,
author = {Apostol Theodora Venera and Barbuceanu Stefania Felicia and Socea Laura Ileana and Draghici Constantin and Saramet Gabriel and Iscrulescu Lucian and Olaru Octavian Tudorel},
title = {Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing
4-(Phenylsulfonyl)phenyl Moiety},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3793-3801},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7649},
url = {https://revistadechimie.ro/Articles.asp?ID=7649}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)

News, Events

Gold Open Access | Source=http://www.plos.org/ | Author=art designer at PLoS

Conferences of Contemporary
Chemistry

Biblioteca Chimiei

Materiale Plastice

REVISTA DE CHIMIE

About

Board

Indexing