The Genetic Profile of Thrombophilia in Reproductive Disorders

Cozaru, Georgeta Camelia; Aschie, Mariana; Mitroi, Anca; Brinzan, Costel; Chisoi, Anca

Georgeta Camelia Cozaru, Mariana Aschie, Anca Mitroi, Costel Brinzan, Anca Chisoi

The Genetic Profile of Thrombophilia in Reproductive Disorders

Abstract:

Some cases of reproductive disorders have a thrombotic etiology. Considering the importance of establishing the cause of miscarriage, we investigated the incidence and associated risks of the most common thrombophilic genes polymorphism - FV G1691A, FV H1299A, Prothrombin G20210A, PAI-1, Factor XIII V34L, MTHFR C677T, MTHFR A1298C and EPCR genes, in women with reproductive disorders. In our research we included 139 women with reproductive disorders and risk for hereditary trombophilia and 139 healthy females without any personal or family history of vein thrombosis or recurrent pregnancy loss. For detection of thrombophilic genes polymorphism we used CVD StripAssay (ViennaLab, Austria) and the tests’ protocols were followed as described by the manufacturer. Our results showed that the concomitant presence of MTHFR A1298C and Factor XIII V34L gene polymorphism had a significant association for recurrent pregnancy loss, while FV H1299A (R2) and MTHFR A1298C gene polymorphisms were correlated with subfertility. We therefore consider that these patients should be recognized as high risk for poor pregnancy outcomes and monitored with specialized follow-up.

Keywords:
Keywords: Inherited thrombophilia genes; reproductive disorders; recurrent pregnancy loss

Issue: 2019, Volume 70, Issue 11

Pages: 3830-3834

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7654

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
COZARU, G.C., ASCHIE, M., MITROI, A., BRINZAN, C., CHISOI, A., The Genetic Profile of Thrombophilia in Reproductive Disorders, Rev. Chim., 70(11), 2019, 3830-3834.

Vancouver
Cozaru GC, Aschie M, Mitroi A, Brinzan C, Chisoi A. The Genetic Profile of Thrombophilia in Reproductive Disorders. Rev. Chim.[internet]. 2019 Nov;70(11):3830-3834. Available from: https://doi.org/10.37358/RC.70.19.11.7654

APA 6th edition
Cozaru, G.C., Aschie, M., Mitroi, A., Brinzan, C. & Chisoi, A. (2019). The Genetic Profile of Thrombophilia in Reproductive Disorders. Revista de Chimie, 70(11), 3830-3834. https://doi.org/10.37358/RC.70.19.11.7654

Harvard
Cozaru, G.C., Aschie, M., Mitroi, A., Brinzan, C., Chisoi, A. (2019). 'The Genetic Profile of Thrombophilia in Reproductive Disorders', Revista de Chimie, 70(11), pp. 3830-3834. https://doi.org/10.37358/RC.70.19.11.7654

IEEE
G.C. Cozaru, M. Aschie, A. Mitroi, C. Brinzan, A. Chisoi, "The Genetic Profile of Thrombophilia in Reproductive Disorders". Revista de Chimie, vol. 70, no. 11, pp. 3830-3834, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7654

Text
Georgeta Camelia Cozaru, Mariana Aschie, Anca Mitroi, Costel Brinzan, Anca Chisoi,
The Genetic Profile of Thrombophilia in Reproductive Disorders,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3830-3834,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7654.
(https://revistadechimie.ro/Articles.asp?ID=7654)
Keywords: Keywords: Inherited thrombophilia genes; reproductive disorders; recurrent pregnancy loss

RIS
TY - JOUR
T1 - The Genetic Profile of Thrombophilia in Reproductive Disorders
A1 - Cozaru, Georgeta Camelia
A2 - Aschie, Mariana
A3 - Mitroi, Anca
A4 - Brinzan, Costel
A5 - Chisoi, Anca
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3830
EP - 3834
UR - https://doi.org/10.37358/RC.70.19.11.7654
KW - Keywords: Inherited thrombophilia genes
KW - reproductive disorders
KW - recurrent pregnancy loss

ER -

BibTex
@article{RevCh2019P3830,
author = {Cozaru Georgeta Camelia and Aschie Mariana and Mitroi Anca and Brinzan Costel and Chisoi Anca},
title = {The Genetic Profile of Thrombophilia in Reproductive Disorders},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3830-3834},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7654},
url = {https://revistadechimie.ro/Articles.asp?ID=7654}
}

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