The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy

Reil, Peter Michael; Maghiar, Teodor Traian; Seidl, Karlheinz; Borza, Ciprian; Nunkoo, Vharoon; Buhas, Camelia Liana; Bungau, Simona; Stanescu, Ana Maria Alexandra; Pop, Ovidiu Laurean; Pusta, Claudia Teodora Judea

Peter Michael Reil, Teodor Traian Maghiar, Karlheinz Seidl, Ciprian Borza, Vharoon Nunkoo, Camelia Liana Buhas, Simona Bungau, Ana Maria Alexandra Stanescu, Ovidiu Laurean Pop, Claudia Teodora Judea Pusta

The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy

Abstract:

A decreased left ventricular ejection fraction (LVEF) was observed in patients suffering from septic shock with normalization of systolic function after 10 days. Similar courses of reversible myocardial dysfunction due to the systemic inflammatory response syndrome were also encountered in other critical illnesses. Since the pathological and histological mechanisms are not fully understood, the present study tries to understand the septic cardiomyopathy related to the apoptotic pathway. Thestudy included a number of 29 cases of adults that died of septic shock being analysed for BCL2 and p53 expression rates of myocardial tissue. This is the first time the expression of BCL2 protein, p53 tumour protein were evaluated in septic shock and septic cardiomyopathy of humans. There was a strong link between the increased expression of BCL2 and of p53 protein in cardiac muscle cells in the studied group (p=0.0300). The study showed a significant correlation between markedly increased values and poor outcome.

Keywords:
septic cardiomyopathy; apoptosis; BCL2; p53

Issue: 2019, Volume 70, Issue 11

Pages: 3842-3846

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7656

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
REIL, P.M., MAGHIAR, T.T., SEIDL, K., BORZA, C., NUNKOO, V., BUHAS, C.L., BUNGAU, S., STANESCU, A.M.A., POP, O.L., PUSTA, C.T.J., The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy, Rev. Chim., 70(11), 2019, 3842-3846.

Vancouver
Reil PM, Maghiar TT, Seidl K, Borza C, Nunkoo V, Buhas CL, Bungau S, Stanescu AMA, Pop OL, Pusta CTJ. The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy. Rev. Chim.[internet]. 2019 Nov;70(11):3842-3846. Available from: https://doi.org/10.37358/RC.70.19.11.7656

APA 6th edition
Reil, P.M., Maghiar, T.T., Seidl, K., Borza, C., Nunkoo, V., Buhas, C.L.,... Pusta, C.T.J. (2019). The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy. Revista de Chimie, 70(11), 3842-3846. https://doi.org/10.37358/RC.70.19.11.7656

Harvard
Reil, P.M., Maghiar, T.T., Seidl, K., Borza, C., Nunkoo, V., Buhas, C.L., Bungau, S., Stanescu, A.M.A., Pop, O.L., Pusta, C.T.J. (2019). 'The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy', Revista de Chimie, 70(11), pp. 3842-3846. https://doi.org/10.37358/RC.70.19.11.7656

IEEE
P.M. Reil, T.T. Maghiar, K. Seidl, C. Borza, V. Nunkoo, C.L. Buhas, S. Bungau, A.M.A. Stanescu, O.L. Pop, C.T.J. Pusta, "The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy". Revista de Chimie, vol. 70, no. 11, pp. 3842-3846, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7656

Text
Peter Michael Reil, Teodor Traian Maghiar, Karlheinz Seidl, Ciprian Borza, Vharoon Nunkoo, Camelia Liana Buhas, Simona Bungau, Ana Maria Alexandra Stanescu, Ovidiu Laurean Pop, Claudia Teodora Judea Pusta,
The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3842-3846,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7656.
(https://revistadechimie.ro/Articles.asp?ID=7656)
Keywords: septic cardiomyopathy; apoptosis; BCL2; p53

RIS
TY - JOUR
T1 - The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy
A1 - Reil, Peter Michael
A2 - Maghiar, Teodor Traian
A3 - Seidl, Karlheinz
A4 - Borza, Ciprian
A5 - Nunkoo, Vharoon
A6 - Buhas, Camelia Liana
A7 - Bungau, Simona
A8 - Stanescu, Ana Maria Alexandra
A9 - Pop, Ovidiu Laurean
A10 - Pusta, Claudia Teodora Judea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3842
EP - 3846
UR - https://doi.org/10.37358/RC.70.19.11.7656
KW - septic cardiomyopathy
KW - apoptosis
KW - BCL2
KW - p53
ER -

BibTex
@article{RevCh2019P3842,
author = {Reil Peter Michael and Maghiar Teodor Traian and Seidl Karlheinz and Borza Ciprian and Nunkoo Vharoon and Buhas Camelia Liana and Bungau Simona and Stanescu Ana Maria Alexandra and Pop Ovidiu Laurean and Pusta Claudia Teodora Judea},
title = {The Role of BCL2 Protein and Tumour Protein p53 in Septic Cardiomyopathy},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3842-3846},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7656},
url = {https://revistadechimie.ro/Articles.asp?ID=7656}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)