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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 11, 3881-3888

https://doi.org/10.37358/RC.70.19.11.7664

Mihai Silviu Tudosie, Cristina Anca Secara, Catalin Gabriel Smarandache, Simona Bicheru, Mihaela Muresan, Bogdan Socea, Nicoleta Grigoriu, Cristinel Dumitru Badiu, Gabriel Epure, Ana Maria Dascalu, Constantin Draghici

The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants

Abstract:

Neurotoxic warfare chemical agents (CWA/NA) induce major toxicological effects to the affected personnel. Their increased toxicity justifies the necessity of developing analytical methods for diagnosis and specific medical counter measures. CWA/NA are extremely toxic agents which are subject to international regulations (The Geneva Protocol regarding the prohibition of chemical weapons). Taking into account the ban on human experimenting due to high toxicity, simulators of neurotoxic chemical agents are being used in laboratories. These are analogue chemical compounds which possess the same relevant physical, chemical and pharmacodynamical properties of the corresponding agents, but with lower intrinsical toxicity. The synthesis and toxicological characterization of these simulators of neurotoxic chemical agents allow the laboratory research of these extremely toxic compounds and the unfolding of risk-free antidote studies. This paper proposes the synthesis and toxicological testing of chemical compounds which simulate sarin (4-nitrophenyl isopropyl methylphosphonate - NIMP) and VX (4-nitrophenyl ethyl methylphosphonate - NEMP).
Keywords:
NIMP; NEMP; neurotoxic chemical agents; acute toxicity; acetylcholinesterase (AchE)

Issue: 2019, Volume 70, Issue 11
Pages: 3881-3888
Publication date: 2019/12/15
https://doi.org/10.37358/RC.70.19.11.7664
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TUDOSIE, M.S., SECARA, C.A., SMARANDACHE, C.G., BICHERU, S., MURESAN, M., SOCEA, B., GRIGORIU, N., BADIU, C.D., EPURE, G., DASCALU, A.M., DRAGHICI, C., The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants, Rev. Chim., 70(11), 2019, 3881-3888.

Vancouver
Tudosie MS, Secara CA, Smarandache CG, Bicheru S, Muresan M, Socea B, Grigoriu N, Badiu CD, Epure G, Dascalu AM, Draghici C. The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants. Rev. Chim.[internet]. 2019 Nov;70(11):3881-3888. Available from: https://doi.org/10.37358/RC.70.19.11.7664


APA 6th edition
Tudosie, M.S., Secara, C.A., Smarandache, C.G., Bicheru, S., Muresan, M., Socea, B.,... Draghici, C. (2019). The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants. Revista de Chimie, 70(11), 3881-3888. https://doi.org/10.37358/RC.70.19.11.7664


Harvard
Tudosie, M.S., Secara, C.A., Smarandache, C.G., Bicheru, S., Muresan, M., Socea, B., Grigoriu, N., Badiu, C.D., Epure, G., Dascalu, A.M., Draghici, C. (2019). 'The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants', Revista de Chimie, 70(11), pp. 3881-3888. https://doi.org/10.37358/RC.70.19.11.7664


IEEE
M.S. Tudosie, C.A. Secara, C.G. Smarandache, S. Bicheru, M. Muresan, B. Socea, N. Grigoriu, C.D. Badiu, G. Epure, A.M. Dascalu, C. Draghici, "The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants". Revista de Chimie, vol. 70, no. 11, pp. 3881-3888, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7664


Text
Mihai Silviu Tudosie, Cristina Anca Secara, Catalin Gabriel Smarandache, Simona Bicheru, Mihaela Muresan, Bogdan Socea, Nicoleta Grigoriu, Cristinel Dumitru Badiu, Gabriel Epure, Ana Maria Dascalu, Constantin Draghici,
The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3881-3888,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7664.
(https://revistadechimie.ro/Articles.asp?ID=7664)
Keywords: NIMP; NEMP; neurotoxic chemical agents; acute toxicity; acetylcholinesterase (AchE)



RIS
TY - JOUR
T1 - The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants
A1 - Tudosie, Mihai Silviu
A2 - Secara, Cristina Anca
A3 - Smarandache, Catalin Gabriel
A4 - Bicheru, Simona
A5 - Muresan, Mihaela
A6 - Socea, Bogdan
A7 - Grigoriu, Nicoleta
A8 - Badiu, Cristinel Dumitru
A9 - Epure, Gabriel
A10 - Dascalu, Ana Maria
A11 - Draghici, Constantin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3881
EP - 3888
UR - https://doi.org/10.37358/RC.70.19.11.7664
KW - NIMP
KW - NEMP
KW - neurotoxic chemical agents
KW - acute toxicity
KW - acetylcholinesterase (AchE)

ER -


BibTex
@article{RevCh2019P3881,
author = {Tudosie Mihai Silviu and Secara Cristina Anca and Smarandache Catalin Gabriel and Bicheru Simona and Muresan Mihaela and Socea Bogdan and Grigoriu Nicoleta and Badiu Cristinel Dumitru and Epure Gabriel and Dascalu Ana Maria and Draghici Constantin},
title = {The Synthesis and Toxicological Characterization of Neurotoxic Chemical Agents Simulants},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3881-3888},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7664},
url = {https://revistadechimie.ro/Articles.asp?ID=7664}
}
 
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