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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 11, 3964-3966

https://doi.org/10.37358/RC.70.19.11.7682

Ioan Sergiu Micu, Marilena Musat, Yousef Al Hamidi, Andrada Dumitru, Anca Rogoveanu, Roxana Emanuela Popoiag

IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication

Abstract:

Chronic viral infections affecting the liver represents a global burden for medical comunities. More than 170 million individuals are infected chronically with hepatitis C virus (HCV), this accounting about 2-3% of the world’s population. Despite numerous progresses aquired in viral pahogenesis and treatment, chronic hepatitis C management is influenced by a multitude of factors. Interleukin IL-28 beta subunit (IL28B) demonstrated to be involved in both sustained virological response (SVR) to treatment, but even with spontaneous viral clearance without any therapy. In the era of direct antiviral agents (DAAs) we aimed to find out what was the real influence of IL28B phenotypes over the response to Peg-IFN and Ribavirin treatment in patients with chronic hepatitis C, many of theses being non-responders or relapsers, and as consequence, to optimize the referal of patients to more expensive and efficient treatments. In a retrospectively manner, we analyzed the IL28B phenotype and its influence over the rapid viral response (RVR), early viral response (EVR) and sustained viral response (SVR), in 250 patients HCV treated patients. We made correlations between the treatment response rates and the IL28B polymorphism.TT phenotype was correlated negatively with all parameters studied, while CC phenotype was correlated with the best response rates. We concluded that IL28B phenotypes interfere with the EVR and SVR rates, IL28B phenotype being an independent prognostic factor for antiviral treatment response in our patient groups, and according to this characteristics, we created the premise to optimize the patients referal to expensive therapies as DAAs.
Keywords:
hepatitis C virus; IL-28 beta subunit;viral treatment

Issue: 2019, Volume 70, Issue 11
Pages: 3964-3966
Publication date: 2019/12/15
https://doi.org/10.37358/RC.70.19.11.7682
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MICU, I.S., MUSAT, M., HAMIDI, Y.A., DUMITRU, A., ROGOVEANU, A., POPOIAG, R.E., IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication, Rev. Chim., 70(11), 2019, 3964-3966.

Vancouver
Micu IS, Musat M, Hamidi YA, Dumitru A, Rogoveanu A, Popoiag RE. IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication. Rev. Chim.[internet]. 2019 Nov;70(11):3964-3966. Available from: https://doi.org/10.37358/RC.70.19.11.7682


APA 6th edition
Micu, I.S., Musat, M., Hamidi, Y.A., Dumitru, A., Rogoveanu, A. & Popoiag, R.E. (2019). IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication. Revista de Chimie, 70(11), 3964-3966. https://doi.org/10.37358/RC.70.19.11.7682


Harvard
Micu, I.S., Musat, M., Hamidi, Y.A., Dumitru, A., Rogoveanu, A., Popoiag, R.E. (2019). 'IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication', Revista de Chimie, 70(11), pp. 3964-3966. https://doi.org/10.37358/RC.70.19.11.7682


IEEE
I.S. Micu, M. Musat, Y.A. Hamidi, A. Dumitru, A. Rogoveanu, R.E. Popoiag, "IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication". Revista de Chimie, vol. 70, no. 11, pp. 3964-3966, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7682


Text
Ioan Sergiu Micu, Marilena Musat, Yousef Al Hamidi, Andrada Dumitru, Anca Rogoveanu, Roxana Emanuela Popoiag,
IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3964-3966,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7682.
(https://revistadechimie.ro/Articles.asp?ID=7682)
Keywords: hepatitis C virus; IL-28 beta subunit;viral treatment


RIS
TY - JOUR
T1 - IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication
A1 - Micu, Ioan Sergiu
A2 - Musat, Marilena
A3 - Hamidi, Yousef Al
A4 - Dumitru, Andrada
A5 - Rogoveanu, Anca
A6 - Popoiag, Roxana Emanuela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3964
EP - 3966
UR - https://doi.org/10.37358/RC.70.19.11.7682
KW - hepatitis C virus
KW - IL-28 beta subunit
KW - viral treatment
ER -


BibTex
@article{RevCh2019P3964,
author = {Micu Ioan Sergiu and Musat Marilena and Hamidi Yousef Al and Dumitru Andrada and Rogoveanu Anca and Popoiag Roxana Emanuela},
title = {IL-28B - Predictor of Sustained Virological Response for IFN-based Regimens in Chronic Hepatitis C and Criteria for Optimizing DAAs Indication},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3964-3966},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7682},
url = {https://revistadechimie.ro/Articles.asp?ID=7682}
}
 
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