LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma

Caba, Ioana Cezara; Cioroiu, Bogdan Ionel; Butnaru, Elena; Jitareanu, Alexandra; Agoroaei, Luminita

Ioana Cezara Caba, Bogdan Ionel Cioroiu, Elena Butnaru, Alexandra Jitareanu, Luminita Agoroaei

LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma

Abstract:

The aim of the study was to validate a bioanalytical method, for quantifying desloratadine, loratadine and cetirizine in biological samples, useful in toxicological studies. The analytical performance was investigated using the following parameters: selectivity, limit of detection and quantification, linearity, precision, accuracy, matrix effect and analytical stability in the biological matrix. The method optimization was performed for the LC-MS/MS Ultimate 3000 instrument provided by Thermo Fisher Scientific.

Keywords:
H1-antihistaminic drugs; human plasma; LC-MS/MS

Issue: 2019, Volume 70, Issue 11

Pages: 4047-4052

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7699

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CABA, I.C., CIOROIU, B.I., BUTNARU, E., JITAREANU, A., AGOROAEI, L., LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma, Rev. Chim., 70(11), 2019, 4047-4052.

Vancouver
Caba IC, Cioroiu BI, Butnaru E, Jitareanu A, Agoroaei L. LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma. Rev. Chim.[internet]. 2019 Nov;70(11):4047-4052. Available from: https://doi.org/10.37358/RC.70.19.11.7699

APA 6th edition
Caba, I.C., Cioroiu, B.I., Butnaru, E., Jitareanu, A. & Agoroaei, L. (2019). LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma. Revista de Chimie, 70(11), 4047-4052. https://doi.org/10.37358/RC.70.19.11.7699

Harvard
Caba, I.C., Cioroiu, B.I., Butnaru, E., Jitareanu, A., Agoroaei, L. (2019). 'LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma', Revista de Chimie, 70(11), pp. 4047-4052. https://doi.org/10.37358/RC.70.19.11.7699

IEEE
I.C. Caba, B.I. Cioroiu, E. Butnaru, A. Jitareanu, L. Agoroaei, "LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma". Revista de Chimie, vol. 70, no. 11, pp. 4047-4052, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7699

Text
Ioana Cezara Caba, Bogdan Ionel Cioroiu, Elena Butnaru, Alexandra Jitareanu, Luminita Agoroaei,
LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 4047-4052,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7699.
(https://revistadechimie.ro/Articles.asp?ID=7699)
Keywords: H1-antihistaminic drugs; human plasma; LC-MS/MS

RIS
TY - JOUR
T1 - LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma
A1 - Caba, Ioana Cezara
A2 - Cioroiu, Bogdan Ionel
A3 - Butnaru, Elena
A4 - Jitareanu, Alexandra
A5 - Agoroaei, Luminita
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 4047
EP - 4052
UR - https://doi.org/10.37358/RC.70.19.11.7699
KW - H1-antihistaminic drugs
KW - human plasma
KW - LC-MS/MS
ER -

BibTex
@article{RevCh2019P4047,
author = {Caba Ioana Cezara and Cioroiu Bogdan Ionel and Butnaru Elena and Jitareanu Alexandra and Agoroaei Luminita},
title = {LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {4047-4052},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7699},
url = {https://revistadechimie.ro/Articles.asp?ID=7699}
}

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