Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline

Aungurencei, Andra; Luchian, Ionut; Goriuc, Ancuta; Constantinescu, Dana; Martu, Ioana; Popa, Diana Diaconu; Vitalariu, Anca; Luchian, Diana; Earar, Kamel; Tatarciuc, Monica

Andra Aungurencei, Ionut Luchian, Ancuta Goriuc, Dana Constantinescu, Ioana Martu, Diana Diaconu Popa, Anca Vitalariu, Diana Luchian, Kamel Earar, Monica Tatarciuc

Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline

Abstract:

Periodontal diseases ranges from simple gum inflammation to serious disease that consists in major damage to the soft tissue and bone teeth support. Periodontal diseases affects the marginal and apical periodontium and results from the interaction between bacterial biofilm and the host response. To determine the concentrations of MMP-8, as a disease marker, in saliva in prosthetic and nonprosthetic, aggressive (AP) and chronic (CP) periodontitis, doxycycline treated patients. 40 patients were distributed into 3 groups: 12 diagnosed with aggressive (AgP), 18 with chronic (CP) periodontitis. Each of these groups was subdivided into 2 subgroups with and without fixed prosthesis. 10 patients were in the normal group. Matrix metalloproteinase 8 (MMP-8) was evaluated before and after systemic doxycycline (Dox) treatment. mean MMP-8 value into the control group was 0.57 ng/mL with a standard deviation (STD) of 0,094 ng/mL. Highest MMP-8 value was established for the nonprosthesis AgP subgroup, before Dox treatment. The highest reduction in MMP-8 levels (40.8%) was between nonprosthesis AgP before Dox treatment and the same group after Doxycycline treamtent. MMP-8 saliva levels are lower than GCF levels, mostly through a dilution mechanism as previous studies had shown. Our study revealed that saliva MMP-8 level is relible marker for AgP but not for CP. Doxycycline treatment, in terms of lowering MMP-8 levels is most effective in patients that have AP and are also wearing fixed.

Keywords:
periodontal disease; fixed prosthesis; biomarker; doxycycline treatment

Issue: 2019, Volume 70, Issue 11

Pages: 4068-4072

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7703

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
AUNGURENCEI, A., LUCHIAN, I., GORIUC, A., CONSTANTINESCU, D., MARTU, I., POPA, D.D., VITALARIU, A., LUCHIAN, D., EARAR, K., TATARCIUC, M., Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline, Rev. Chim., 70(11), 2019, 4068-4072.

Vancouver
Aungurencei A, Luchian I, Goriuc A, Constantinescu D, Martu I, Popa DD, Vitalariu A, Luchian D, Earar K, Tatarciuc M. Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline. Rev. Chim.[internet]. 2019 Nov;70(11):4068-4072. Available from: https://doi.org/10.37358/RC.70.19.11.7703

APA 6th edition
Aungurencei, A., Luchian, I., Goriuc, A., Constantinescu, D., Martu, I., Popa, D.D.,... Tatarciuc, M. (2019). Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline. Revista de Chimie, 70(11), 4068-4072. https://doi.org/10.37358/RC.70.19.11.7703

Harvard
Aungurencei, A., Luchian, I., Goriuc, A., Constantinescu, D., Martu, I., Popa, D.D., Vitalariu, A., Luchian, D., Earar, K., Tatarciuc, M. (2019). 'Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline', Revista de Chimie, 70(11), pp. 4068-4072. https://doi.org/10.37358/RC.70.19.11.7703

IEEE
A. Aungurencei, I. Luchian, A. Goriuc, D. Constantinescu, I. Martu, D.D. Popa, A. Vitalariu, D. Luchian, K. Earar, M. Tatarciuc, "Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline". Revista de Chimie, vol. 70, no. 11, pp. 4068-4072, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7703

Text
Andra Aungurencei, Ionut Luchian, Ancuta Goriuc, Dana Constantinescu, Ioana Martu, Diana Diaconu Popa, Anca Vitalariu, Diana Luchian, Kamel Earar, Monica Tatarciuc,
Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 4068-4072,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7703.
(https://revistadechimie.ro/Articles.asp?ID=7703)
Keywords: periodontal disease; fixed prosthesis; biomarker; doxycycline treatment

RIS
TY - JOUR
T1 - Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline
A1 - Aungurencei, Andra
A2 - Luchian, Ionut
A3 - Goriuc, Ancuta
A4 - Constantinescu, Dana
A5 - Martu, Ioana
A6 - Popa, Diana Diaconu
A7 - Vitalariu, Anca
A8 - Luchian, Diana
A9 - Earar, Kamel
A10 - Tatarciuc, Monica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 4068
EP - 4072
UR - https://doi.org/10.37358/RC.70.19.11.7703
KW - periodontal disease
KW - fixed prosthesis
KW - biomarker
KW - doxycycline treatment
ER -

BibTex
@article{RevCh2019P4068,
author = {Aungurencei Andra and Luchian Ionut and Goriuc Ancuta and Constantinescu Dana and Martu Ioana and Popa Diana Diaconu and Vitalariu Anca and Luchian Diana and Earar Kamel and Tatarciuc Monica},
title = {Collagenase-2- (MMP-8) as a Poimt - of- care Biomerker in Periodontal Disease in Patients with or Without Fixed Prosthesis Therapeutic Response to Doxycycline},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {4068-4072},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7703},
url = {https://revistadechimie.ro/Articles.asp?ID=7703}
}

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