PHYSICO- CHEMICAL STUDIES ON SOLID DISPERSIONS OF NIFLUMINIC ACID PREPARED WITH PVP
Nifluminic acid is an important anti-inflammatory drug with low aqueous solubility. In order to increase the degree of dissolution of nifluminic acid, products were prepared with polyvinylpyrrolidone (PVP) K-25, using physical mixing and solvent evaporation methods. The solubilities of the products were characterized by means of dissolution and in vitro membrane diffusion from simulated media. The wettability properties of the pure ingredient and its products were determined, with registration of their contact angles. In contrast with the very poor solubility of pure nifluminic acid, the dispersion of the drug in the polymers considerably enhanced the dissolution. This can be attributed to the improved wettability and dispersibility, the particle size reduction and the decrease in the crystalline fraction of the drug.