ELENA MITREA, CRISTINA OTT, AURELIA MEGHEA NEW APPROACHES ON THE SYNTHESIS OF EFFECTIVE NANOSTRUCTURED LIPID CARRIERS
Lipid based particles such as solid lipid nanoparticles and nanostructured lipid carriers are among the most promising carrier systems used in many domains, e.g. medicine, cosmetics and food industry. The aim of this study was to evaluate the influence of various kinds of solid lipid matrices on synthesis of effective nanostructured lipid carriers with appropriate average diameters and physical stability. For this purpose two solid lipid mixtures (glycerol monostearate with carnauba wax and glycerol monostearate with beeswax) in combination with three kinds of vegetable oils enriched in w-3, -5, -6 and -9 fatty acids (e.g. raspberry oil, rice oil, pomegranate oil) have been used for preparation of lipid nanocarriers. The free lipid nanocarriers and ivy leaves extract loaded nanocarriers were synthesized by high shear homogenization coupled with high pressure homogenization. The effect of surfactants mixture and loading with vegetable mixture has been followed by dynamic light scattering, electrokinetic potential measurements and differential scanning calorimetry.
Keywords: nanostructured carriers, solid lipids, high pressure homogenization, physical stability