OVIDIU RUSALIM PETRIS, CATALINA LIONTE, LAURENTIU SORODOC, ANTIGONA TROFOR, EUGEN GAZZI, MILENA ADINA MAN THE USE OF CHEMISTRY IN UNDERSTANDING THE PATHOGENIC MECHANISMS OF ORGANOPHOSPHATES RELATED CARDIAC TOXICITY
Organophosphate substances, although known to exert their toxic effects mainly by inhibiting cholinesterase enzymes, associate a cardiac toxicity with pathogenic mechanisms that are not only limited to this anticholinergic effect. The aim is to discover the most reliable explanation for the late cardiac toxic effect of organophosphates in acute intoxication. The experimental research compres evaluation of oxidative stress system, serum electrolytes levels and evidences of myocardial injury (cardiac enzymes, histological examinations) while monitoring, through gas chromatography, the presence of the toxic at cardiac level, during a period of eight days evolution of an acute intoxication with trichlorfon at two different dosages (200 and 400 mg/kg body weight). Electrolyte disorders and the intervention of oxidative stress were not documented to be involved in this type of outcome. A pathogenic mechanism of myocarditis was documented in the evolution of the acute organophosphates intoxication due to a direct action of the toxic to the heart. The late effect is associated with a dysphasic accumulation of the organophosphate at myocardial level.
Keywords: gas chromatography, organophosphates, myocarditis, oxidative stress