BOGDAN TITA, CLAUDIU MORGOVAN, DUMITRU TITA, TEODORA ALINA NEAG ANTI-INFLAMMATORY DRUGS INTERACTING WITH ZN(II) METAL ION SYNTHESIS, CHARACTERIZATION AND THERMAL BEHAVIOUR OF THE COMPLEX WITH KETOPROFEN
A complex of Zn(II) metal ion with the anti-inflammatory drug, 2-(3-benzoylphenyl)-propionic acid (Ketoprofen) was isolated and investigated. The complex was characterized by elemental analysis, Fourier transformed infrared spectroscopy (FT-IR), X-ray diffraction powder (XRPD) and thermal analysis.The thermal behavior was studied by TG/DTG and DTA methods under non-isothermal conditions in a dynamic air atmosphere. The results provided informations of the composition, structure, thermal behavior, dehydration and thermal decomposition. The spectroscopic study suggest that the carboxylate group of ketoprofen is coordinate to metal as bidentate bond.