DRAGOS ACATRINEI, CARMEN GENTIMIR (AMITITELOAIE), CATALINA ZAHARIA (AVRAM), CRISTINA OANA RADUCANU,GEANINA BOGZA, LILIANA CHELARU, DECEBAL VASINCU, OTILIA BOISTEANU, MARCEL COSTULEANU RELATIONSHIPS OF NR4A1 AGONISTS BIOCHEMICAL EFFECTS WITH PRE-B LYMPHOCYTES APOPTOSIS
Cytosporone B (Csn-B) is the known natural agonist of NR4A1/Nur77 orphan nuclear receptor. In our study, Csn-B failed to induce important apoptosis in isolated mouse pre-B cells, although used in high concentrations (100 mM) and for long time (24 h). Retinoid X receptors (RXRs) form heterodimers with NR4A1 ones, although the role of such complexes remain unidentified. 9-cis retinoic acid (9 -CRA), the agonist for RXRs, is showing a very similar effect to Csn-B concerning the apoptosis of mouse pre-B cells. The treatment with both molecules could increase in a significant, although reduced manner, the amount of apoptosis in pre-B cells. Further studies are needed to describe the mechanisms underlying such apoptotic effects.