MIRCEA FLORIN BERCEANU, IULIA PINZARU, TIBERIU BRATU, ZORIN CRAINICEANU, LAVINIA CEUTA,FLORIN BORCAN, DORINA CORICOVAC, COSMIN CITU EVOLUTION OF MURINE MELANOMA IN C57BL/6J FEMALE MICE A NON-INVASIVE EVALUATION
One of the most aggressive type of cancer is represented by malignant melanoma, which represents a continuous challenge for researchers in various related fields given that the mechanism is not completely understood, and current treatments do not provide a high survival rate. Animal models have proven to be of great help in the study and understanding of the mechanisms of various cancers including malignant melanoma. Considering those described above, the purpose of this study was to obtain a murine melanoma model using C57BL/6J female mice by subcutaneously inoculation of a B164A5 cell suspension. For the experiments, were used female C57BL/6J mice with the age of 8-10 weeks, 8 mice/group. The day before cells inoculation all the animals were shaved on the back using a razor. B164A5 cell suspension was subcutaneously inoculated to the females and examined daily. All the mice used developed tumors and the values of the noninvasive measurements of the physiological skin parameters were discussed in this material.