DORINA MANTU, VASILICHIA ANTOCI, VIOLETA VASILACHE, CATALINA MIHAELA LUCA STRUCTURE AND ANTICANCER ACTIVITY OF SOME BIS-PYRIDAZINE DERIVATIVES
The synthesis, anticancer activity and X-ray crystal structure of diethyl 2,2'-(3,3'-oxybis(4,1-phenylene))bis(6-oxopyridazine-3,1(6H)-diyl)) diacetate are reported. The in vitro anticancer activity against HeLa cell line was tested, compound showing a moderate cytotoxicity. The structure of compound was assigned by elemental and spectral analysis, the X-ray data proving unambiguously the structure. The compound crystallizes in the space group P1 with a = 16.753(1) Ao, b = 12.6931(7) Ao, c = 12.8775(8) Ao, a =90°, b= 107.328(6)°, g = 90°, V= 2614.1(3) and Z = 4. Accurate molecular parameters for the heterocyclic system were obtained from intensity data collected at 295 K. The molecule assumes a bowl stereochemistry.