PAVEL ONOFREI, ELENA CARMEN COTRUTZ, ANA EMANUELA BOTEZ, VASILE BOGDAN GRECU, CARMEN SOLCAN, ANCA ILEANA SIN, DANIELA CRISTINA DIMITRIU, PAUL DAN SIRBU, VASILE LUCIAN BOICULESE6, VLAD PORUMB, LAURA STOICA, DOINITA TEMELIE OLINICI MASPIN AND EZRINA - BIOMARKER MOLECULES IN COLORECTAL CANCER CORRELATIVE IMMUNOHISTOCHEMICAL STUDY
The results of the recent years researches support the need for personalized therapeutic of cancer by completing the clinical, imagistic and histopathological diagnosis with molecular studies to identify new useful biomarkers for diagnosis, prognosis and tumor progression. Maspin is a non-inhibitory serine protease having a proapoptotic activity, suppressor of tumor invasion, metastasis and angiogenesis. Ezrin is a member of Ezrin/Radixin/Moesin (ERM) family, involved in cellular adhesion mechanisms, motility and invasiveness of tumor cells. In colorectal tumors, there is a heterogeneity of research results regarding the clinical significance of the maspin due to a possible partnership with other molecules with which it interacts through the same signaling pathways. Our study investigated the two molecule‘s immunoreactivity (IR) in 92 colorectal tumors highlighting an inverse correlation between ezrin‘s and maspin‘s expression, suggesting the fact that ezrin‘s overexpression could influence maspin‘s tumoral suppressor role. Furthermore there was observed a difference of the molecules IR within the same tumoral stage, suggesting their utility regarding the treatment protocol of these tumors.