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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 2959-2962

https://doi.org/10.37358/RC.19.8.7464

Cristian Scheau, Ioana Anca Badarau, Ioana Gabriela Lupescu, Ioana Raluca Papacocea, Gratiela Livia Mihai, Marius Toma Papacocea, Andreea Elena Scheau

The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study

Abstract:

The glutamate-glutamine cycle is essential for sustaining the neuronal secretion of the excitatory neurotransmitter glutamate. Hepatic encephalopathy, even in its most discreet form, minimal hepatic encephalopathy (MHE), interferes with the glutamate and glutamine balance due to the increase in ammonia levels in the central nervous system (CNS), induced by a combination of liver dysfunction, increased blood-brain barrier permeability and many other factors. An experimental study on 21 patients with chronic liver disease and 11 healthy volunteers was performed. Magnetic resonance spectroscopy demonstrated an increase of the glutamate-glutamine complex peak, with high predictive value for MHE, especially when the metabolites are referenced to creatine, a stabile metabolite in the CNS. This paper also explores the pathophysiology of MHE with emphasis on the involvement of the glutamate-glutamine cycle in the development of this complication.
Keywords:
glutamate; glutamine; creatine; minimal hepatic encephalopathy; magnetic resonance spectroscopy

Issue: 2019, Volume 70, Issue 8
Pages: 2959-2962
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7464
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SCHEAU, C., BADARAU, I.A., LUPESCU, I.G., PAPACOCEA, I.R., MIHAI, G.L., PAPACOCEA, M.T., SCHEAU, A.E., The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study, Rev. Chim., 70(8), 2019, 2959-2962.

Vancouver
Scheau C, Badarau IA, Lupescu IG, Papacocea IR, Mihai GL, Papacocea MT, Scheau AE. The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study. Rev. Chim.[internet]. 2019 Aug;70(8):2959-2962. Available from: https://doi.org/10.37358/RC.19.8.7464


APA 6th edition
Scheau, C., Badarau, I.A., Lupescu, I.G., Papacocea, I.R., Mihai, G.L., Papacocea, M.T. & Scheau, A.E. (2019). The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study. Revista de Chimie, 70(8), 2959-2962. https://doi.org/10.37358/RC.19.8.7464


Harvard
Scheau, C., Badarau, I.A., Lupescu, I.G., Papacocea, I.R., Mihai, G.L., Papacocea, M.T., Scheau, A.E. (2019). 'The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study', Revista de Chimie, 70(8), pp. 2959-2962. https://doi.org/10.37358/RC.19.8.7464


IEEE
C. Scheau, I.A. Badarau, I.G. Lupescu, I.R. Papacocea, G.L. Mihai, M.T. Papacocea, A.E. Scheau, "The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study". Revista de Chimie, vol. 70, no. 8, pp. 2959-2962, 2019. [online]. https://doi.org/10.37358/RC.19.8.7464


Text
Cristian Scheau, Ioana Anca Badarau, Ioana Gabriela Lupescu, Ioana Raluca Papacocea, Gratiela Livia Mihai, Marius Toma Papacocea, Andreea Elena Scheau,
The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2959-2962,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7464.
(https://revistadechimie.ro/Articles.asp?ID=7464)
Keywords: glutamate; glutamine; creatine; minimal hepatic encephalopathy; magnetic resonance spectroscopy


RIS
TY - JOUR
T1 - The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study
A1 - Scheau, Cristian
A2 - Badarau, Ioana Anca
A3 - Lupescu, Ioana Gabriela
A4 - Papacocea, Ioana Raluca
A5 - Mihai, Gratiela Livia
A6 - Papacocea, Marius Toma
A7 - Scheau, Andreea Elena
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2959
EP - 2962
UR - https://doi.org/10.37358/RC.19.8.7464
KW - glutamate
KW - glutamine
KW - creatine
KW - minimal hepatic encephalopathy
KW - magnetic resonance spectroscopy
ER -


BibTex
@article{RevCh2019P2959,
author = {Scheau Cristian and Badarau Ioana Anca and Lupescu Ioana Gabriela and Papacocea Ioana Raluca and Mihai Gratiela Livia and Papacocea Marius Toma and Scheau Andreea Elena},
title = {The Pivotal Role of the Glutamate - glutamine Cycle in Minimal Hepatic Encephalopathy. An experimental magnetic resonance spectroscopy study},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2959-2962},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7464},
url = {https://revistadechimie.ro/Articles.asp?ID=7464}
}
 
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