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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 2963-2967

https://doi.org/10.37358/RC.19.8.7465

Bogdan Ioan Coculescu, Diana Popescu, Lucia Ionescu, Gabriela Dumitrescu, Monica Marilena Tantu, Marius Necsulescu, Alina Paunescu

Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections

Abstract:

Knowledge of antibiotic resistance mechanisms is absolutely necessary to successfully fight against multi-resistant bacteria, the solutions to this issue being a direct consequence of understanding the mechanisms underlying its occurrence. Considering that in Romania more than 92.3% of patients have been receiving antimicrobial prophylaxis in surgery for more than one day, and empirical therapy is very common, the increasing antibiotic resistance is an important problem. The experiments were performed at the Military Medical Research Center on the 26 multiple drug resistance (MDR) bacterial strains from health care-associated infections (HAI): Escherichia coli (3), Klebsiella spp. (4), Pseudomonas aeruginosa 10), Proteus mirabilis (1), Staphylococcus aureus (7) and Enterobacter cloacae (1). They were isolated and initially identified by the Medical Analysis Laboratory of the Dr. Al. Gafencu Emergency Military Hospital, Constanta and the Microbiology Laboratory from the Military Medical National Institute for Research and Development Cantacuzino of Bucharest. Bacterial strains were reseeded on specific culture media, and identification was based on culture, morpho-tinctorial characters and biochemical properties. Antibiotic susceptibility testing was performed by the Kirby-Bauer diffusion method, following the CLSI 2016 guidelines. The results obtained lead to the idea of reconsidering the strategy for the use of antimicrobial substances by the following actions: performing in vitro sensitivity tests, close collaboration between the clinician and microbiologist, finding additional methods for assessing the effective concentrations of the antibiotic at the level of the infections. The observed percentage of antibiotic resistance in our study was 85.72%, that being much higher than the mentioned percentage by the European Antibiotic Surveillance Report (EARS-Net) for Romania in 2013 (25-50%).
Keywords:
antimicrobial resistance; multiple drug resistance (MDR); healthcare-associated infections (HAI)

Issue: 2019, Volume 70, Issue 8
Pages: 2963-2967
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7465
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
COCULESCU, B.I., POPESCU, D., IONESCU, L., DUMITRESCU, G., TANTU, M.M., NECSULESCU, M., PAUNESCU, A., Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections, Rev. Chim., 70(8), 2019, 2963-2967.

Vancouver
Coculescu BI, Popescu D, Ionescu L, Dumitrescu G, Tantu MM, Necsulescu M, Paunescu A. Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections. Rev. Chim.[internet]. 2019 Aug;70(8):2963-2967. Available from: https://doi.org/10.37358/RC.19.8.7465


APA 6th edition
Coculescu, B.I., Popescu, D., Ionescu, L., Dumitrescu, G., Tantu, M.M., Necsulescu, M. & Paunescu, A. (2019). Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections. Revista de Chimie, 70(8), 2963-2967. https://doi.org/10.37358/RC.19.8.7465


Harvard
Coculescu, B.I., Popescu, D., Ionescu, L., Dumitrescu, G., Tantu, M.M., Necsulescu, M., Paunescu, A. (2019). 'Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections', Revista de Chimie, 70(8), pp. 2963-2967. https://doi.org/10.37358/RC.19.8.7465


IEEE
B.I. Coculescu, D. Popescu, L. Ionescu, G. Dumitrescu, M.M. Tantu, M. Necsulescu, A. Paunescu, "Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections". Revista de Chimie, vol. 70, no. 8, pp. 2963-2967, 2019. [online]. https://doi.org/10.37358/RC.19.8.7465


Text
Bogdan Ioan Coculescu, Diana Popescu, Lucia Ionescu, Gabriela Dumitrescu, Monica Marilena Tantu, Marius Necsulescu, Alina Paunescu,
Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2963-2967,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7465.
(https://revistadechimie.ro/Articles.asp?ID=7465)
Keywords: antimicrobial resistance; multiple drug resistance (MDR); healthcare-associated infections (HAI)


RIS
TY - JOUR
T1 - Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections
A1 - Coculescu, Bogdan Ioan
A2 - Popescu, Diana
A3 - Ionescu, Lucia
A4 - Dumitrescu, Gabriela
A5 - Tantu, Monica Marilena
A6 - Necsulescu, Marius
A7 - Paunescu, Alina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2963
EP - 2967
UR - https://doi.org/10.37358/RC.19.8.7465
KW - antimicrobial resistance
KW - multiple drug resistance (MDR)
KW - healthcare-associated infections (HAI)
ER -


BibTex
@article{RevCh2019P2963,
author = {Coculescu Bogdan Ioan and Popescu Diana and Ionescu Lucia and Dumitrescu Gabriela and Tantu Monica Marilena and Necsulescu Marius and Paunescu Alina},
title = {Research on New Patterns of Antimicrobial Resistant in Bacterial Pathogens Identified in Healthcare-associated Infections},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2963-2967},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7465},
url = {https://revistadechimie.ro/Articles.asp?ID=7465}
}
 
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