Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?

Georgescu, Doina; Iurciuc, Mircea Stefan; Petre, Izabella; Georgescu, Liviu Andrei; Szasz, Florin; Ionita, Ioana; Ancusa, Oana Elena; Ionita, Mihai; Lighezan, Daniel

Doina Georgescu, Mircea Stefan Iurciuc, Izabella Petre, Liviu Andrei Georgescu, Florin Szasz, Ioana Ionita, Oana Elena Ancusa, Mihai Ionita, Daniel Lighezan

Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?

Abstract:

Irritable bowel syndrome (IBS) is characterized by a multitude of symptoms digestive and extra- digestive that need at some point a multidisciplinary approach. This study aimed at profiling IBS associated with chronic pelvic pain (CPP) in young females. A cross sectional observatory study on 40 consecutive young female patients (under 45 years) with IBS (Rome III) was performed. Patients were assigned in two groups, as matched pairs, based on the presence of chronic pelvic pain (CPP) symptoms: cystalgia, urinary urge and dyspareunia: CPP(+) vs. CPP(-) and undertook clinical examinations with special protocols related to migraine disability, fibromyalgia, temporo-mandibular joint dysfunction, as well as assessment of anxiety and severity of abdominal pain. Laboratory work-up (blood, urine and stool) as well as multiple exams: digestive endoscopy, abdominal and pelvic ultrasound//CT were performed. Results: CPP (+) group displayed higher CRP, TNF-alpha, gut dysbiosis (DB) and abdominal pain severity, as well as associated fibromyalgia, migraine and anxiety mood disorder. DB positively correlated with inflammatory markers and symptoms characterizing CPP. In conclusion, young female IBS patients with concurrent CPP symptoms often experienced other associated functional pain conditions like FM and migraine along with anxiety, more severe abdominal complaints as well as higher gut DB and consecutively subclinical pro-inflammatory status. Strong positive correlations of gut DB to inflammatory markers as well as to CPP symptoms give the relationship IBS-CPP a new perspective.

Keywords:
CPP; IBS; inflammation; gut dysbiosis

Issue: 2019, Volume 70, Issue 10

Pages: 3634-3637

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7611

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GEORGESCU, D., IURCIUC, M.S., PETRE, I., GEORGESCU, L.A., SZASZ, F., IONITA, I., ANCUSA, O.E., IONITA, M., LIGHEZAN, D., Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?, Rev. Chim., 70(10), 2019, 3634-3637.

Vancouver
Georgescu D, Iurciuc MS, Petre I, Georgescu LA, Szasz F, Ionita I, Ancusa OE, Ionita M, Lighezan D. Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?. Rev. Chim.[internet]. 2019 Oct;70(10):3634-3637. Available from: https://doi.org/10.37358/RC.19.10.7611

APA 6th edition
Georgescu, D., Iurciuc, M.S., Petre, I., Georgescu, L.A., Szasz, F., Ionita, I.,... Lighezan, D. (2019). Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?. Revista de Chimie, 70(10), 3634-3637. https://doi.org/10.37358/RC.19.10.7611

Harvard
Georgescu, D., Iurciuc, M.S., Petre, I., Georgescu, L.A., Szasz, F., Ionita, I., Ancusa, O.E., Ionita, M., Lighezan, D. (2019). 'Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?', Revista de Chimie, 70(10), pp. 3634-3637. https://doi.org/10.37358/RC.19.10.7611

IEEE
D. Georgescu, M.S. Iurciuc, I. Petre, L.A. Georgescu, F. Szasz, I. Ionita, O.E. Ancusa, M. Ionita, D. Lighezan, "Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?". Revista de Chimie, vol. 70, no. 10, pp. 3634-3637, 2019. [online]. https://doi.org/10.37358/RC.19.10.7611

Text
Doina Georgescu, Mircea Stefan Iurciuc, Izabella Petre, Liviu Andrei Georgescu, Florin Szasz, Ioana Ionita, Oana Elena Ancusa, Mihai Ionita, Daniel Lighezan,
Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3634-3637,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7611.
(https://revistadechimie.ro/Articles.asp?ID=7611)
Keywords: CPP; IBS; inflammation; gut dysbiosis

RIS
TY - JOUR
T1 - Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?
A1 - Georgescu, Doina
A2 - Iurciuc, Mircea Stefan
A3 - Petre, Izabella
A4 - Georgescu, Liviu Andrei
A5 - Szasz, Florin
A6 - Ionita, Ioana
A7 - Ancusa, Oana Elena
A8 - Ionita, Mihai
A9 - Lighezan, Daniel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3634
EP - 3637
UR - https://doi.org/10.37358/RC.19.10.7611
KW - CPP
KW - IBS
KW - inflammation
KW - gut dysbiosis
ER -

BibTex
@article{RevCh2019P3634,
author = {Georgescu Doina and Iurciuc Mircea Stefan and Petre Izabella and Georgescu Liviu Andrei and Szasz Florin and Ionita Ioana and Ancusa Oana Elena and Ionita Mihai and Lighezan Daniel},
title = {Chronic Pelvic Pain and Irritable Bowel Syndrome: Is Subclinical Inflammation Bridging the Gap?},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3634-3637},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7611},
url = {https://revistadechimie.ro/Articles.asp?ID=7611}
}

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