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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 10, 3644-3648

https://doi.org/10.37358/RC.19.10.7613

Camelia Larisa Vonica, Adriana Fodor, Gabriela Roman, Andrada Alina Mureasan, Anca Daniela Farcas, Georgeta Victoria Inceu, Adriana Rusu, Carmen Emanuela Georgescu

Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance

Abstract:

The aim of the paper is to detect insulin resistance (IR) biomarkers via metabolomics. It is important to understand the PCOS pathophysiology, diagnosis measures and, subsequently, to improve treatment type and time of IR in PCOS. In most cases, almost half of the women with PCOS have IR which is triggered by inflammation, glucotoxicity and lipotoxicity. In this work was conducted a systematic review of all the papers that used metabolomics for detecting IR biomarkers in PCOS women. The exclusion criteria were: reviews, study population with women bellow 18 years of age, studies including animals and articles not in English, remaining 4 records. The results from the literature shown that phosphatidylcholines were decreased in IR PCOS women when compared to controls. Nonetheless, trans-2-hexenoylcoa, linoleic acid, leucine, myristic acid and palmitic acid regarding lipid metabolism and tyrosine, lysine, phenylalanine a-aminoadipic acid regarding amino acid metabolism were also corelated to IR in PCOS women when compared with healthy or IR controls. Lactate was the only increased metabolite related to glucose metabolism in IR PCOS women. Metabolic alteration in PCOS women with IR when are compared with controls and results that those are brought by both PCOS and IR. Lyso-phosphatidylcholine have an important pro-inflammatory and altered insulin signaling effect, both alterations being considered hallmarks of PCOS women. Serine hyperphosphorylation of the receptor accentuates IR by decreasing the signaling of insulin receptor. Moreover, high levels of lactate correlated with IR in PCOS women may indicate high muscle glycolysis, hepatic glucose production and peripheral glucose uptake. IR biomarkers in PCOS women were evidenced by metabolomics technique.
Keywords:
Polycystic ovary syndrome; insulin resistance; metabolomics; women; plasma; metabolism; biomarkers

Issue: 2019, Volume 70, Issue 10
Pages: 3644-3648
Publication date: 2019/11/15
https://doi.org/10.37358/RC.19.10.7613
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
VONICA, C.L., FODOR, A., ROMAN, G., MUREASAN, A.A., FARCAS, A.D., INCEU, G.V., RUSU, A., GEORGESCU, C.E., Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance, Rev. Chim., 70(10), 2019, 3644-3648.

Vancouver
Vonica CL, Fodor A, Roman G, Mureasan AA, Farcas AD, Inceu GV, Rusu A, Georgescu CE. Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance. Rev. Chim.[internet]. 2019 Oct;70(10):3644-3648. Available from: https://doi.org/10.37358/RC.19.10.7613


APA 6th edition
Vonica, C.L., Fodor, A., Roman, G., Mureasan, A.A., Farcas, A.D., Inceu, G.V., Rusu, A. & Georgescu, C.E. (2019). Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance. Revista de Chimie, 70(10), 3644-3648. https://doi.org/10.37358/RC.19.10.7613


Harvard
Vonica, C.L., Fodor, A., Roman, G., Mureasan, A.A., Farcas, A.D., Inceu, G.V., Rusu, A., Georgescu, C.E. (2019). 'Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance', Revista de Chimie, 70(10), pp. 3644-3648. https://doi.org/10.37358/RC.19.10.7613


IEEE
C.L. Vonica, A. Fodor, G. Roman, A.A. Mureasan, A.D. Farcas, G.V. Inceu, A. Rusu, C.E. Georgescu, "Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance". Revista de Chimie, vol. 70, no. 10, pp. 3644-3648, 2019. [online]. https://doi.org/10.37358/RC.19.10.7613


Text
Camelia Larisa Vonica, Adriana Fodor, Gabriela Roman, Andrada Alina Mureasan, Anca Daniela Farcas, Georgeta Victoria Inceu, Adriana Rusu, Carmen Emanuela Georgescu,
Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3644-3648,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7613.
(https://revistadechimie.ro/Articles.asp?ID=7613)
Keywords: Polycystic ovary syndrome; insulin resistance; metabolomics; women; plasma; metabolism; biomarkers


RIS
TY - JOUR
T1 - Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance
A1 - Vonica, Camelia Larisa
A2 - Fodor, Adriana
A3 - Roman, Gabriela
A4 - Mureasan, Andrada Alina
A5 - Farcas, Anca Daniela
A6 - Inceu, Georgeta Victoria
A7 - Rusu, Adriana
A8 - Georgescu, Carmen Emanuela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3644
EP - 3648
UR - https://doi.org/10.37358/RC.19.10.7613
KW - Polycystic ovary syndrome
KW - insulin resistance
KW - metabolomics
KW - women
KW - plasma
KW - metabolism
KW - biomarkers
ER -


BibTex
@article{RevCh2019P3644,
author = {Vonica Camelia Larisa and Fodor Adriana and Roman Gabriela and Mureasan Andrada Alina and Farcas Anca Daniela and Inceu Georgeta Victoria and Rusu Adriana and Georgescu Carmen Emanuela},
title = {Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3644-3648},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7613},
url = {https://revistadechimie.ro/Articles.asp?ID=7613}
}
 
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